Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Dominic Winter"'
Autor:
Agata N. Makar, Alina Boraman, Peter Mosen, Joanne E. Simpson, Jair Marques, Tim Michelberger, Stuart Aitken, Ann P. Wheeler, Dominic Winter, Alex von Kriegsheim, Noor Gammoh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Autophagy is a finely orchestrated process required for the lysosomal degradation of cytosolic components. The final degradation step is essential for clearing autophagic cargo and recycling macromolecules. Using a CRISPR/Cas9-based screen,
Externí odkaz:
https://doaj.org/article/6883251db50c4cf790616ebe8bd9529f
Autor:
Jiyao Song, Liesa Steidle, Isabelle Steymans, Jasjot Singh, Anne Sanner, Lena Böttinger, Dominic Winter, Thomas Becker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The mitochondrial ATP synthase produces the bulk of cellular ATP. Here, the authors report a function of the mitochondrial Hsp70 in the formation of the catalytical head and in its assembly with the peripheral stalk to form the mature ATP synthase.
Externí odkaz:
https://doaj.org/article/5449185eaa60477cac63a47f91921501
Autor:
Jasjot Singh, Hadeer Elhabashy, Pathma Muthukottiappan, Markus Stepath, Martin Eisenacher, Oliver Kohlbacher, Volkmar Gieselmann, Dominic Winter
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Protein complexes play a decisive role for lysosomal function. Here, the authors use cross-linking mass spectrometry and integrative modeling to investigate lysosomes and early endosomes; characterizing protein interactions, structures, and the cargo
Externí odkaz:
https://doaj.org/article/daf33278d958445881e9a33767251849
Autor:
Adam Aleksander Karpiński, Julio Cesar Torres Elguera, Anne Sanner, Witold Konopka, Leszek Kaczmarek, Dominic Winter, Anna Konopka, Ewa Bulska
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2466 (2022)
Mass spectrometry-based proteomics aims to study the proteome both qualitatively and quantitatively. A key step in proteomic analysis is sample preparation, which is crucial for reliable results. We investigated the effect of the composition of the h
Externí odkaz:
https://doaj.org/article/6f49293cd9bb43fe872336879bc4b6d2
Autor:
Wiebke A. Rehorst, Maximilian P. Thelen, Hendrik Nolte, Clara Türk, Sebahattin Cirak, Jonathan M. Peterson, G. William Wong, Brunhilde Wirth, Marcus Krüger, Dominic Winter, Min Jeong Kye
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Spinal muscular atrophy (SMA) is an inherited neuromuscular disorder, which causes dysfunction/loss of lower motor neurons and muscle weakness as well as atrophy. While SMA is primarily considered as a motor neuron disease, recent data sugge
Externí odkaz:
https://doaj.org/article/3a45f28b932f4b949072050c3401599a
Autor:
Mukhran Khundadze, Federico Ribaudo, Adeela Hussain, Jan Rosentreter, Sandor Nietzsche, Melanie Thelen, Dominic Winter, Birgit Hoffmann, Muhammad Awais Afzal, Tanja Hermann, Cecilia de Heus, Eva-Maria Piskor, Christian Kosan, Patricia Franzka, Lisa von Kleist, Tobias Stauber, Judith Klumperman, Markus Damme, Tassula Proikas-Cezanne, Christian A. Hübner
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 419-431 (2019)
Hereditary spastic paraplegia is a spastic gait disorder that arises from degeneration of corticospinal axons. The subtype SPG48 is associated with mutations in the zeta subunit of the adaptor protein complex five (AP5). AP5 function and the pathophy
Externí odkaz:
https://doaj.org/article/c5d0d4197e294f66a8340361edbe5c4c
Autor:
Pablo S. Contreras, Pablo J. Tapia, Lila González-Hódar, Ivana Peluso, Chiara Soldati, Gennaro Napolitano, Maria Matarese, Macarena Las Heras, Cristian Valls, Alexis Martinez, Elisa Balboa, Juan Castro, Nancy Leal, Frances M. Platt, Andrzej Sobota, Dominic Winter, Andrés D. Klein, Diego L. Medina, Andrea Ballabio, Alejandra R. Alvarez, Silvana Zanlungo
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101691- (2020)
Summary: The transcription factor EB (TFEB) has emerged as a master regulator of lysosomal biogenesis, exocytosis, and autophagy, promoting the clearance of substrates stored in cells. c-Abl is a tyrosine kinase that participates in cellular signalin
Externí odkaz:
https://doaj.org/article/c6a46857605147c4a1da866ca411c8d6
Autor:
Elisa Balboa, Tamara Marín, Juan Esteban Oyarzún, Pablo S. Contreras, Robert Hardt, Thea van den Bosch, Alejandra R. Alvarez, Boris Rebolledo-Jaramillo, Andres D. Klein, Dominic Winter, Silvana Zanlungo
Publikováno v:
Cells, Vol 10, Iss 8, p 2159 (2021)
Niemann-Pick type C disease (NPCD) is a lysosomal storage disorder caused by mutations in the NPC1 gene. The most affected tissues are the central nervous system and liver, and while significant efforts have been made to understand its neurological c
Externí odkaz:
https://doaj.org/article/bad4e229bef34b36b08551674950517c
Publikováno v:
Proteomes, Vol 9, Iss 1, p 4 (2021)
In eukaryotic cells, lysosomes play a crucial role in the breakdown of a variety of components ranging from small molecules to complex structures, ascertaining the continuous turnover of cellular building blocks. Furthermore, they act as a regulatory
Externí odkaz:
https://doaj.org/article/b077959e6d4c40f0801bf360f9a960ae
Autor:
Jafar Jalaei, Mehdi Fazeli, Hamid Rajaian, Somayeh Layeghi Ghalehsoukhteh, Alireza Dehghani, Dominic Winter
Publikováno v:
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 3, Pp 259-264 (2016)
Objective: To investigate the antihistamine-releasing effect of a peptide isolated from wasp venom of Vespa orientalis. Methods: This peptide was separated from crude venom by chromatography methods and mass spectrometry. Then various concentrations
Externí odkaz:
https://doaj.org/article/192561ed38734f07901b448b7332f36c