Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dominic T Love"'
Autor:
Elin Sjöberg, Marit Melssen, Mark Richards, Yindi Ding, Catarina Chanoca, Dongying Chen, Emmanuel Nwadozi, Sagnik Pal, Dominic T. Love, Takeshi Ninchoji, Masabumi Shibuya, Michael Simons, Anna Dimberg, Lena Claesson-Welsh
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
Endothelial phospholipase Cγ (PLCγ) is essential for vascular development; however, its role in healthy, mature, or pathological vessels is unexplored. Here, we show that PLCγ was prominently expressed in vessels of several human cancer forms, not
Externí odkaz:
https://doaj.org/article/7698f966a69a496bb790494d6f6061b0
Autor:
Takeshi Ninchoji, Dominic T Love, Ross O Smith, Marie Hedlund, Dietmar Vestweber, William C Sessa, Lena Claesson-Welsh
Publikováno v:
eLife, Vol 10 (2021)
Background: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed. Method
Externí odkaz:
https://doaj.org/article/22d057117123401086a68b774154e78c
Autor:
Dominic T. Love, Chaorui Guo, Evelina I. Nikelshparg, Nadezda A. Brazhe, Olga Sosnovtseva, Clare L. Hawkins
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101602- (2020)
A host of chronic inflammatory diseases are accelerated by the formation of the powerful oxidant hypochlorous acid (HOCl) by myeloperoxidase (MPO). In the presence of thiocyanate (SCN-), the production of HOCl by MPO is decreased in favour of the for
Externí odkaz:
https://doaj.org/article/2cc5583077c5435d9491bd1b30f7f243
Autor:
Takeshi Ninchoji, Dietmar Vestweber, William C. Sessa, Dominic T. Love, Marie Hedlund, Ross O Smith, Lena Claesson-Welsh
Publikováno v:
eLife, Vol 10 (2021)
Background: Hypoxia and consequent production of vascular endothelial growth factor A (VEGFA) promote blood vessel leakiness and edema in ocular diseases. Anti-VEGFA therapeutics may aggravate hypoxia; therefore, therapy development is needed. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5322aeed9aa0b57843f1492282a82136
https://doi.org/10.1101/2020.11.24.396077
https://doi.org/10.1101/2020.11.24.396077
Autor:
Isabel Egaña, Lena Claesson-Welsh, Mats Hellström, Jimmy Larsson, Riikka Pietilä, Ross O Smith, Takeshi Ninchoji, Francis P. Roche, Elisabet Ekvärn, Suvi Jauhiainen, Dominic T Love, Chiara Testini, Philipp Berger, Anja Nitzsche
Publikováno v:
EMBO Reports
Cell signalling governs cellular behaviour and is therefore subject to tight spatiotemporal regulation. Signalling output is modulated by specialized cell membranes and vesicles which contain unique combinations of lipids and proteins. The phosphatid
Autor:
Evelina I. Nikelshparg, Olga Sosnovtseva, Clare L. Hawkins, Nadezda A. Brazhe, Dominic T. Love, Chaorui Guo
Publikováno v:
Redox Biology, Vol 36, Iss, Pp 101602-(2020)
Love, D T, Guo, C, Nikelshparg, E I, Brazhe, N A, Sosnovtseva, O & Hawkins, C L 2020, ' The role of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) in the induction of mitochondrial dysfunction in macrophages ', Redox Biology, vol. 36, 101602 . https://doi.org/10.1016/j.redox.2020.101602
Redox Biology
Love, D T, Guo, C, Nikelshparg, E I, Brazhe, N A, Sosnovtseva, O & Hawkins, C L 2020, ' The role of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) in the induction of mitochondrial dysfunction in macrophages ', Redox Biology, vol. 36, 101602 . https://doi.org/10.1016/j.redox.2020.101602
Redox Biology
A host of chronic inflammatory diseases are accelerated by the formation of the powerful oxidant hypochlorous acid (HOCl) by myeloperoxidase (MPO). In the presence of thiocyanate (SCN-), the production of HOCl by MPO is decreased in favour of the for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29832796a0bad0fe88e284430023b3dd
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423176
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-423176
Publikováno v:
Acta Ophthalmologica. 97
Autor:
Melanie Y. White, Stuart J. Cordwell, Michael J. Davies, Tessa J. Barrett, Clare L. Hawkins, Dominic T. Love
Publikováno v:
Free Radical Biology and Medicine. 94:88-98
Myeloperoxidase (MPO) released at sites of inflammation catalyzes the formation of the oxidants hypochlorous acid (HOCl) and hypothiocyanous acid (HOSCN) from H2O2 and halide and pseudo-halide ions. HOCl, a major oxidant produced under physiological
Publikováno v:
Free Radical Biology and Medicine. 128:S104
Myeloperoxidase is a vital component of the human immune system, producing the potent oxidant hypochlorous acid (HOCl), to kill bacteria and other invading pathogens. However, an overproduction of HOCl causes oxidative stress and damage to host cells