Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Dominic R. Pye"'
Autor:
Roderick T. Stark, Dominic R. Pye, Wenyi Chen, Oliver J. Newton, Benjamin J. Deadman, Philip W. Miller, Jenny-Lee Panayides, Darren L. Riley, Klaus Hellgardt, King Kuok (Mimi) Hii
A synthetic route to an anti-cancer drug, lapatinib, was devised to support the development of a sustainable manufacturing process in South Africa. Quantitative metrics were employed to evaluate the sustainability of the key steps of the reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9f055551c476d4e44a59076bcd63bd
http://hdl.handle.net/10044/1/99067
http://hdl.handle.net/10044/1/99067
Publikováno v:
Synthesis. 47:1761-1765
The reaction of 2-halobenzyl halides with the borate anion Li[(Ph)( t -Bu)Bpin] leads not only to the expected arylation at the benzyl position, but also to some Suzuki biaryl cross-coupling. Preliminary mechanistic investigations hint towards the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67d87aa70ce9b418bb10a4f4c448abad
https://doi.org/10.1055/s-0034-1380135
https://doi.org/10.1055/s-0034-1380135
Publikováno v:
Chemical Science
A bimetallic system consisting of Cu-carbene and Mn-carbonyl co-catalysts was employed for carbonylative C–C coupling of arylboronic esters with alkyl halides, allowing for the convergent synthesis of ketones.
A bimetallic system consisting of
A bimetallic system consisting of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa05d5edc577445a262f5ca7d544843a
https://pubmed.ncbi.nlm.nih.gov/28966784
https://pubmed.ncbi.nlm.nih.gov/28966784
Autor:
Robin B. Bedford, Damien Martin Murphy, Dominic R. Pye, Timothy Gallagher, Peter Brenner, Emma Carter
Publikováno v:
Organometallics. 33:5940-5943
Activation of B2pin2 with tBuLi facilitates the Fe-catalyzed borylation of alkyl, allyl, benzyl, and aryl halides via the formation of Li[B2pin2(tBu)] (1). The reaction of 1 with a representative iron phosphine precatalyst generates the unique iron(I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2afa9949b0e3bb914e4bf42b7314ea0
https://doi.org/10.1021/om500847j
https://doi.org/10.1021/om500847j
Autor:
Paul M. Cogswell, Peter Brenner, Damien Martin Murphy, Robin B. Bedford, Emily C. Neeve, Timothy Gallagher, Joshua Nunn, Emma Carter, Jeremy N. Harvey, Dominic R. Pye, Thomas W. Carvell
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 20(26)
While attractive, the iron-catalyzed coupling of arylboron reagents with alkyl halides typically requires expensive or synthetically challenging diphosphine ligands. Herein, we show that primary and secondary alkyl bromides and chlorides, as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5767a58c4d12e3feacb38f9ebe030e6d
https://pubmed.ncbi.nlm.nih.gov/24715587
https://pubmed.ncbi.nlm.nih.gov/24715587