Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Dominic Paquin-Proulx"'
Autor:
Mohammad Arif Rahman, Massimiliano Bissa, Hanna Scinto, Savannah E. Howe, Sarkis Sarkis, Zhong-Min Ma, Anna Gutowska, Xunqing Jiang, Christina C. Luo, Luca Schifanella, Ramona Moles, Isabela Silva de Castro, Shraddha Basu, Kombo F. N’guessan, LaTonya D. Williams, Manuel Becerra-Flores, Melvin N. Doster, Tanya Hoang, Hyoyoung Choo-Wosoba, Emmanuel Woode, Yongjun Sui, Georgia D. Tomaras, Dominic Paquin-Proulx, Mangala Rao, James D. Talton, Xiang-Peng Kong, Susan Zolla-Pazner, Timothy Cardozo, Genoveffa Franchini, Jay A. Berzofsky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Systemic vaccination of macaques with V1-deleted (ΔV1) envelope immunogens reduce the risk of SIVmac251 acquisition by approximately 60%, with protective roles played by V2-specific ADCC and envelope-specific mucosal IL-17+NKp44+ innate lym
Externí odkaz:
https://doaj.org/article/c46022c8eff943a69e28ba2d4818429f
Autor:
Thembi Mdluli, Bonnie M. Slike, Daniel J. Curtis, Zhanna Shubin, Ursula Tran, Yifan Li, Vincent Dussupt, Letzibeth Mendez-Rivera, Suteeraporn Pinyakorn, Daniel J. Stieh, Frank L. Tomaka, Hanneke Schuitemaker, Maria G. Pau, Donn J. Colby, Eugène Kroon, Carlo Sacdalan, Mark de Souza, Nittaya Phanupak, Denise C. Hsu, Jintanat Ananworanich, Julie A. Ake, Lydie Trautmann, Sandhya Vasan, Merlin L. Robb, Shelly J. Krebs, Dominic Paquin-Proulx, Morgane Rolland
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114344- (2024)
Summary: A heterologous Ad26/MVA vaccine was given prior to an analytic treatment interruption (ATI) in people living with HIV-1 (mainly CRF01_AE) who initiated antiretroviral treatment (ART) during acute HIV-1. We investigate the impact of Ad26/MVA
Externí odkaz:
https://doaj.org/article/2a53194be3584d4cb1d89d2981acfbb5
Autor:
Rajeshwer S. Sankhala, Kerri G. Lal, Jaime L. Jensen, Vincent Dussupt, Letzibeth Mendez-Rivera, Hongjun Bai, Lindsay Wieczorek, Sandra V. Mayer, Michelle Zemil, Danielle A. Wagner, Samantha M. Townsley, Agnes Hajduczki, William C. Chang, Wei-Hung Chen, Gina C. Donofrio, Ningbo Jian, Hannah A. D. King, Cynthia G. Lorang, Elizabeth J. Martinez, Phyllis A. Rees, Caroline E. Peterson, Fabian Schmidt, Tricia J. Hart, Debra K. Duso, Lawrence W. Kummer, Sean P. Casey, Jazmean K. Williams, Shruthi Kannan, Bonnie M. Slike, Lauren Smith, Isabella Swafford, Paul V. Thomas, Ursula Tran, Jeffrey R. Currier, Diane L. Bolton, Edgar Davidson, Benjamin J. Doranz, Theodora Hatziioannou, Paul D. Bieniasz, Dominic Paquin-Proulx, William W. Reiley, Morgane Rolland, Nancy J. Sullivan, Sandhya Vasan, Natalie D. Collins, Kayvon Modjarrad, Gregory D. Gromowski, Victoria R. Polonis, Nelson L. Michael, Shelly J. Krebs, M. Gordon Joyce
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The repeat emergence of SARS-CoV-2 variants of concern (VoC) with decreased susceptibility to vaccine-elicited antibodies highlights the need to develop next-generation vaccine candidates that confer broad protection. Here we describe the an
Externí odkaz:
https://doaj.org/article/61dc74f1c5d84f64ac1178c032cab9f4
Autor:
Kombo F. N’guessan, Kawthar Machmach, Isabella Swafford, Margaret C. Costanzo, Lindsay Wieczorek, Dohoon Kim, Siriwat Akapirat, Victoria R. Polonis, Punnee Pitisuttithum, Sorachai Nitayaphan, Sanjay Gurunathan, Faruk Sinangil, Suwat Chariyalertsak, Julie A. Ake, Robert J. O’connell, Sandhya Vasan, Dominic Paquin-Proulx
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The RV144 Thai phase III clinical trial’s canarypox–protein HIV vaccine regimen showed modest efficacy in reducing infection. We therefore sought to determine the effects of vaccine administration on innate cell activation and subsequent associat
Externí odkaz:
https://doaj.org/article/b63b37f19fa546188d5104a25d963234
Autor:
Shikha Shrivastava, Joshua M. Carmen, Zhongyan Lu, Shraddha Basu, Rajeshwer S. Sankhala, Wei-Hung Chen, Phuong Nguyen, William C. Chang, Jocelyn King, Courtney Corbitt, Sandra Mayer, Jessica S. Bolton, Alexander Anderson, Isabella Swafford, Guillermo D. Terriquez, Hung V. Trinh, Jiae Kim, Ousman Jobe, Dominic Paquin-Proulx, Gary, R. Matyas, Gregory D. Gromowski, Jeffrey R. Currier, Elke Bergmann-Leitner, Kayvon Modjarrad, Nelson L. Michael, M. Gordon Joyce, Allison M. W. Malloy, Mangala Rao
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract This study demonstrates the impact of adjuvant on the development of T follicular helper (Tfh) and B cells, and their influence on antibody responses in mice vaccinated with SARS-CoV-2-spike-ferritin-nanoparticle (SpFN) adjuvanted with eithe
Externí odkaz:
https://doaj.org/article/d8f58b2e3b264c9caf318f2cc61ee799
Autor:
Julie A. Ake, Kristopher Paolino, Jack N. Hutter, Susan Biggs Cicatelli, Leigh Anne Eller, Michael A. Eller, Margaret C. Costanzo, Dominic Paquin-Proulx, Merlin L. Robb, Chi L. Tran, Lalaine Anova, Linda L. Jagodzinski, Lucy A. Ward, Nicole Kilgore, Janice Rusnak, Callie Bounds, Christopher S. Badorrek, Jay W. Hooper, Steven A. Kwilas, Ine Ilsbroux, Dickson Nkafu Anumendem, Auguste Gaddah, Georgi Shukarev, Viki Bockstal, Kerstin Luhn, Macaya Douoguih, Cynthia Robinson
Publikováno v:
Vaccines, Vol 12, Iss 5, p 497 (2024)
The safety and immunogenicity of the two-dose Ebola vaccine regimen MVA-BN-Filo, Ad26.ZEBOV, 14 days apart, was evaluated in people without HIV (PWOH) and living with HIV (PLWH). In this observer-blind, placebo-controlled, phase 2 trial, healthy adul
Externí odkaz:
https://doaj.org/article/d508ae26d5664c20827179054ade0b7e
Autor:
Viviana Cobos Jiménez, Aviva Geretz, Andrey Tokarev, Philip K. Ehrenberg, Selase Deletsu, Kawthar Machmach, Prakriti Mudvari, J. Natalie Howard, Amanda Zelkoski, Dominic Paquin-Proulx, Gregory Q. Del Prete, Caroline Subra, Eli A. Boritz, Alberto Bosque, Rasmi Thomas, Diane L. Bolton
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108015- (2023)
Summary: Persistent HIV-1 reservoirs of infected CD4 T cells are a major barrier to HIV-1 cure, although the mechanisms by which they are established and maintained in vivo remain poorly characterized. To elucidate host cell gene expression patterns
Externí odkaz:
https://doaj.org/article/610f567e63764468b36e1cbb767d05df
Autor:
Wei-Hung Chen, Agnes Hajduczki, Elizabeth J. Martinez, Hongjun Bai, Hanover Matz, Thomas M. Hill, Eric Lewitus, William C. Chang, Layla Dawit, Caroline E. Peterson, Phyllis A. Rees, Adelola B. Ajayi, Emily S. Golub, Isabella Swafford, Vincent Dussupt, Sapna David, Sandra V. Mayer, Sandrine Soman, Caitlin Kuklis, Courtney Corbitt, Jocelyn King, Misook Choe, Rajeshwer S. Sankhala, Paul V. Thomas, Michelle Zemil, Lindsay Wieczorek, Tricia Hart, Debora Duso, Larry Kummer, Lianying Yan, Spencer L. Sterling, Eric D. Laing, Christopher C. Broder, Jazmean K. Williams, Edgar Davidson, Benjamin J. Doranz, Shelly J. Krebs, Victoria R. Polonis, Dominic Paquin-Proulx, Morgane Rolland, William W. Reiley, Gregory D. Gromowski, Kayvon Modjarrad, Helen Dooley, M. Gordon Joyce
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
SARS-CoV-2 variants of concern continue to emerge, reducing vaccine efficacy and limiting therapeutic options. Here, Chen and colleagues describe the identification and design of shark nanobodies with pansarbecovirus activity.
Externí odkaz:
https://doaj.org/article/898fe823bbf4468ea5527a2d0a41fa28
Autor:
Yifan Li, Mélanie Merbah, Suzanne Wollen-Roberts, Bradley Beckman, Thembi Mdluli, Isabella Swafford, Sandra V. Mayer, Jocelyn King, Courtney Corbitt, Jeffrey R. Currier, Heather Liu, Allahna Esber, Suteeraporn Pinyakorn, Ajay Parikh, Leilani V. Francisco, Nittaya Phanuphak, Jonah Maswai, John Owuoth, Hannah Kibuuka, Michael Iroezindu, Emmanuel Bahemana, Sandhya Vasan, Julie A. Ake, Kayvon Modjarrad, Gregory Gromowski, Dominic Paquin-Proulx, Morgane Rolland
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 11, Pp 2214-2225 (2022)
Prior immune responses to coronaviruses might affect human SARS-CoV-2 response. We screened 2,565 serum and plasma samples collected from 2013 through early 2020, before the COVID-19 pandemic began, from 2,250 persons in 4 countries in Africa (Kenya,
Externí odkaz:
https://doaj.org/article/aefcd1a5a71b4b3f8a8cbb0b90b6bda0
Autor:
Gregory D. Gromowski, Camila Macedo Cincotta, Sandra Mayer, Jocelyn King, Isabella Swafford, Michael K. McCracken, Dante Coleman, Jennifer Enoch, Casey Storme, Janice Darden, Sheila Peel, Diane Epperson, Kelly McKee, Jeffrey R. Currier, Jason Okulicz, Dominic Paquin-Proulx, Jessica Cowden, Kristina Peachman
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104683- (2023)
Summary: Background: COVID-19 vaccines have been critical for protection against severe disease following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but gaps remain in our understanding of the immune responses that co
Externí odkaz:
https://doaj.org/article/a60a5b979d714af7b8b9f44a94b6fae7