Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dominic P Golec"'
Autor:
Deanna M Santer, Gillian E S Minty, Dominic P Golec, Julia Lu, Julia May, Afshin Namdar, Juhi Shah, Shokrollah Elahi, David Proud, Michael Joyce, D Lorne Tyrrell, Michael Houghton
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008515 (2020)
Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, the primary antiviral function of IFN-λs has been propos
Externí odkaz:
https://doaj.org/article/9cef71d5d96e4ee7ace8f108f9ac10b6
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53300 (2013)
T cell development is a highly dynamic process that is driven by interactions between developing thymocytes and the thymic microenvironment. Upon entering the thymus, the earliest thymic progenitors, called CD4(-)CD8(-) 'double negative' (DN) thymocy
Externí odkaz:
https://doaj.org/article/041b7b2df2af44b8a47fb179bcc25d36
Autor:
Pedro H. Gazzinelli-Guimaraes, PhD, Dominic P. Golec, PhD, Erik P. Karmele, PhD, Joshua Sciurba, BSc, Pablo Bara-Garcia, MSc, Tom Hill, PhD, Byunghyun Kang, PhD, Sasisekhar Bennuru, PhD, Pamela L. Schwartzberg, MD, Thomas B. Nutman, MD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 4, Pp 100131- (2023)
Background: The immunologic mechanisms underlying pulmonary type 2 inflammation, including the dynamics of eosinophil recruitment to the lungs, still need to be elucidated. Objective: We sought to investigate how IL-13–producing TH2 effector cells
Externí odkaz:
https://doaj.org/article/79aeb3efc24e4143a3a43cc7a323031a
Autor:
Masato Ogishi, Rui Yang, Rémy Rodriguez, Dominic P. Golec, Emmanuel Martin, Quentin Philippot, Jonathan Bohlen, Simon J. Pelham, Andrés Augusto Arias, Taushif Khan, Manar Ata, Fatima Al Ali, Flore Rozenberg, Xiao-Fei Kong, Maya Chrabieh, Candice Laine, Wei-Te Lei, Ji Eun Han, Yoann Seeleuthner, Zenia Kaul, Emmanuelle Jouanguy, Vivien Béziat, Leila Youssefian, Hassan Vahidnezhad, V. Koneti Rao, Bénédicte Neven, Claire Fieschi, Davood Mansouri, Mohammad Shahrooei, Sevgi Pekcan, Gulsum Alkan, Melike Emiroğlu, Hüseyin Tokgöz, Jouni Uitto, Fabian Hauck, Jacinta Bustamante, Laurent Abel, Sevgi Keles, Nima Parvaneh, Nico Marr, Pamela L. Schwartzberg, Sylvain Latour, Jean-Laurent Casanova, Stéphanie Boisson-Dupuis
Publikováno v:
Journal of Experimental Medicine. 220
Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK deficiency, a condition associated with severe EBV disease that r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df6e1dfbe7f7c13e89ffd1eb29a9719
https://doi.org/10.1084/jem.20220484
https://doi.org/10.1084/jem.20220484
Autor:
Kristoffer H. Johansen, Dominic P. Golec, Bonnie Huang, Chung Park, Julie H. Thomsen, Silvia Preite, Jennifer L. Cannons, Fabien Garçon, Edward C. Schrom, Christina J. F. Courrèges, Tibor Z. Veres, James Harrison, Meritxell Nus, James D. Phelan, Wolfgang Bergmeier, John H. Kehrl, Klaus Okkenhaug, Pamela L. Schwartzberg
Publikováno v:
Sci Signal
The integrin lymphocyte function–associated antigen 1 (LFA-1) helps to coordinate the migration, adhesion, and activation of T cells through interactions with intercellular adhesion molecule 1 (ICAM-1) and ICAM-2. LFA-1 is activated during the enga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fb60de16563b9cf6b443148e4cfc18
https://doi.org/10.1126/scisignal.abl9169
https://doi.org/10.1126/scisignal.abl9169
Autor:
Mohammad Fatehi, Peter E. Light, Wentong Long, Shubham Soni, Brett Boonen, Koenraad Philippaert, Rees G. Kelly, Katarina Ondrusova, M. Joanne Lemieux, Dominic P. Golec, Rashmi Panigrahi, Amy J. Barr, Yi Yu, Matt Hubert, Troy A. Baldwin, Scott A. Campbell
Publikováno v:
The Journal of Physiology. 598:4321-4338
KEY POINTS: 25-Hydroxyvitamin D (25OHD) is a partial agonist of TRPV1 whereby 25OHD can weakly activate TRPV1 yet antagonize the stimulatory effects of the full TRPV1 agonists capsaicin and oleoyl dopamine. 25OHD binds to TRPV1 within the same vanill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d27542c640e30802ea8e35cf7c99ff
https://doi.org/10.1113/jp279961
https://doi.org/10.1113/jp279961
Autor:
Pamela L. Schwartzberg, Dominic P Golec, Kristoffer H. Johansen, Klaus Okkenhaug, Julie H Thomsen
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant mouse models and PI3K inhibitors. Furthermore, characterisat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cf3b9ff55bf311ebadda6867007bf9
https://www.repository.cam.ac.uk/handle/1810/328472
https://www.repository.cam.ac.uk/handle/1810/328472
Autor:
Kevin Joannou, Dominic P. Golec, Haiguang Wang, Laura M. Henao-Caviedes, Julia F. May, Rees G. Kelly, Rigel Chan, Stephen C. Jameson, Troy A. Baldwin
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 208(9)
Several unique waves of γδ T cells are generated solely in the fetal/neonatal thymus, whereas additional γδ T cell subsets are generated in adults. One intriguing feature of γδ T cell development is the coordination of differentiation and acqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3dbd002bd5197c1bc8b7e12c6f58c7e
https://pubmed.ncbi.nlm.nih.gov/35396221
https://pubmed.ncbi.nlm.nih.gov/35396221
Autor:
Juhi Shah, D. Lorne Tyrrell, Julia May, Michael A. Joyce, Gillian E. S. Minty, Julia Lu, Afshin Namdar, Dominic P. Golec, Shokrollah Elahi, Michael Houghton, Deanna M. Santer, David Proud
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 4, p e1008515 (2020)
PLoS Pathogens, Vol 16, Iss 4, p e1008515 (2020)
Type III interferons (IFN-lambdas(λ)) are important cytokines that inhibit viruses and modulate immune responses by acting through a unique IFN-λR1/IL-10RB heterodimeric receptor. Until now, the primary antiviral function of IFN-λs has been propos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcce81c70a4bf20a85fb74427662fba
http://europepmc.org/articles/PMC7217487
http://europepmc.org/articles/PMC7217487
Autor:
Dominic P. Golec, Jillian McCann, Romy E. Hoeppli, Laura M. Henao Caviedes, Megan K. Levings, Troy A. Baldwin
Publikováno v:
The Journal of Experimental Medicine
Golec et al. show that RasGRP1, a critical Ras activator in thymocytes, is required for TCRαβ+CD8αα IEL development by regulating the survival of a heterogeneous population of thymic progenitors that receive a strong TCR signal. Therefore, RasGRP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbac832bdee79274009b2ca0c05cfc34
http://europepmc.org/articles/PMC5551581
http://europepmc.org/articles/PMC5551581