Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells

Autor: Michael Rotherham, Yasamin Moradi, Tasmin Nahar, Dominic Mosses, Neil Telling, Alicia J. El Haj

Publikováno v: Frontiers in Medical Technology, Vol 4 (2022)

TWIK-related K+ 1 (TREK1) is a potassium channel expressed in the nervous system with multiple functions including neurotransmission and is a prime pharmacological target for neurological disorders. TREK1 gating is controlled by a wide range of exter

Externí odkaz: https://doaj.org/article/f622db2762c64d91b5373a94387c989b

Kinetic modelling of [(11)C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis

Autor: Federico Roncaroli, Dominic Mosses, Deborah Jones, Alessandra Bertoldo, Nisha Singh, Federico Turkheimer, Gaia Rizzo, Erjon Agushi, Tiago Reis Marques, Mattia Veronese, Peter S. Bloomfield, Oliver D. Howes

Publikováno v: Veronese, M, Reis Marques, T, Bloomfield, P S, Rizzo, G, Singh, N, Jones, D, Agushi, E, Mosses, D, Bertoldo, A, Howes, O, Roncaroli, F & Turkheimer, F E 2017, ' Kinetic modelling of [(11)C]PBR28 for 18 kDa translocator protein PET data : A validation study of vascular modelling in the brain using XBD173 and tissue analysis ', Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism . https://doi.org/10.1177/0271678X17712388

The 18 kDa translocator protein (TSPO) is a marker of microglia activation in the central nervous system and represents the main target of radiotracers for the in vivo quantification of neuroinflammation with positron emission tomography (PET). TSPO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8fb074214172d3064836b32861b78c
https://europepmc.org/articles/PMC6434448/