Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Dominic M. Walsh"'
Autor:
Zemin Wang, Ming Jin, Wei Hong, Wen Liu, David Reczek, Valentina N. Lagomarsino, Yuan Hu, Tim Weeden, Matthew P. Frosch, Tracy L. Young-Pearse, Laurent Pradier, Dennis Selkoe, Dominic M. Walsh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Despite ongoing debate, the amyloid β-protein (Aβ) remains the prime therapeutic target for the treatment of Alzheimer’s disease (AD). However, rational drug design has been hampered by a lack of knowledge about neuroactive Aβ. To help
Externí odkaz:
https://doaj.org/article/a44ed862eab649ab94c4fe38529e56d1
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Amyloid β-protein (Aβ) plays an initiating role in Alzheimer’s disease (AD), but only a small number of groups have studied Aβ extracted from human brain. Most prior studies have utilized synthetic Aβ peptides, but the relevance of these test t
Externí odkaz:
https://doaj.org/article/af7ee4075a3f402cadc6dc3a355e04a5
Autor:
David Mengel, Wen Liu, Robert J. Glynn, Dennis J. Selkoe, Andre Strydom, Florence Lai, H. Diana Rosas, Amy Torres, Vasiliki Patsiogiannis, Brian Skotko, Dominic M. Walsh
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2020)
Abstract Background Down syndrome (DS) is the most common genetic cause of Alzheimer’s disease (AD), but diagnosis of AD in DS is challenging due to the intellectual disability which accompanies DS. When disease-modifying agents for AD are approved
Externí odkaz:
https://doaj.org/article/765d7c94e9064dc89f729ff61c72457b
Autor:
Tomas Ondrejcak, Neng-Wei Hu, Yingjie Qi, Igor Klyubin, Grant T. Corbett, Graham Fraser, Michael S. Perkinton, Dominic M. Walsh, Andrew Billinton, Michael J. Rowan
Publikováno v:
Neurobiology of Disease, Vol 127, Iss , Pp 582-590 (2019)
Soluble synaptotoxic aggregates of the main pathological proteins of Alzheimer's disease, amyloid β-protein (Aß) and tau, have rapid and potent inhibitory effects on long-term potentiation (LTP). Although the promotion of synaptic weakening mechani
Externí odkaz:
https://doaj.org/article/ff95f3803853489a8ff9a0588ee8803a
Autor:
David Mengel, Tze How Mok, Akin Nihat, Wen Liu, Robert A. Rissman, Douglas Galasko, Henrik Zetterberg, Simon Mead, John Collinge, Dominic M. Walsh
Publikováno v:
Cells, Vol 10, Iss 12, p 3514 (2021)
This study investigates the diagnostic and prognostic potential of different forms of tau in biofluids from patients with Creutzfeldt-Jakob disease (CJD). Extracellular tau, which is molecularly heterogeneous, was measured using ultra-sensitive custo
Externí odkaz:
https://doaj.org/article/cdbdd2558fdc456aa6bffb6167e61b9a
Autor:
Diana J. Cha, David Mengel, Maja Mustapic, Wen Liu, Dennis J. Selkoe, Dimitrios Kapogiannis, Douglas Galasko, Robert A. Rissman, David A. Bennett, Dominic M. Walsh
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
It was recently discovered that brain cells release extracellular vesicles (EV) which can pass from brain into blood. These findings raise the possibility that brain-derived EV’s present in blood can be used to monitor disease processes occurring i
Externí odkaz:
https://doaj.org/article/c18a7503e7f6458f86bfd3892a7a15c2
Autor:
Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N. Lagomarsino, Tiernan T. O’Malley, Wen Liu, Charles R. Vanderburg, Matthew P. Frosch, Tracy Young-Pearse, Dennis J. Selkoe, Dominic M. Walsh
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and appli
Externí odkaz:
https://doaj.org/article/1b248bb1ced34f1e829628bfcb182dd4
Autor:
Ming Lei, Huixin Xu, Zhangyuan Li, Zemin Wang, Tiernan T. O'Malley, Dainan Zhang, Dominic M. Walsh, Pingyi Xu, Dennis J. Selkoe, Shaomin Li
Publikováno v:
Neurobiology of Disease, Vol 85, Iss , Pp 111-121 (2016)
Epileptic activity may be more prevalent in early stage Alzheimer's disease (AD) than previously believed. Several studies report spontaneous seizures and interictal discharges in mouse models of AD undergoing age-related Aβ accumulation. The mechan
Externí odkaz:
https://doaj.org/article/f0335e4fcad6439e8aee2320f0547106
Autor:
Alexandra J. Mably, Wen Liu, Jessica M. Mc Donald, Jean-Cosme Dodart, Frédérique Bard, Cynthia A. Lemere, Brian O'Nuallain, Dominic M. Walsh
Publikováno v:
Neurobiology of Disease, Vol 82, Iss , Pp 372-384 (2015)
Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (AD). A leading hypothesis proposes that a small amphipathic fragment of APP, the amyloid β-protein (Aβ), self-associates to form soluble assemblies loosel
Externí odkaz:
https://doaj.org/article/afee23fa7f1540d192cf9316420c48a9
Autor:
Claire J. Sarell, Emma Quarterman, Daniel C.-M. Yip, Cassandra Terry, Andrew J. Nicoll, Jonathan D. F. Wadsworth, Mark A. Farrow, Dominic M. Walsh, John Collinge
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein (PrPC). Ligands that bind to PrPC can inhibit prion propagation and neurotoxi
Externí odkaz:
https://doaj.org/article/229b8c2701a0414b8a25fe465d116345