Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Dominic M Walsh"'
Autor:
Monichan Phay, Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Veronika Blinder, Tiernan T O'Malley, Alan Solomon, Dominic M Walsh, Brian O'Nuallain
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137344 (2015)
Amyloid-reactive IgGs isolated from pooled blood of normal individuals (pAbs) have demonstrated clinical utility for amyloid diseases by in vivo targeting and clearing amyloidogenic proteins and peptides. We now report the following three novel findi
Externí odkaz:
https://doaj.org/article/d9c973e149054991ba50bef3823c4302
Autor:
Alfred T Welzel, Angela D Williams, Helen P McWilliams-Koeppen, Luis Acero, Alfred Weber, Veronika Blinder, Alex Mably, Sebastian Bunk, Corinna Hermann, Michael A Farrell, Hartmut J Ehrlich, Hans P Schwarz, Dominic M Walsh, Alan Solomon, Brian O'Nuallain
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50317 (2012)
Soluble non-fibrillar assemblies of amyloid-beta (Aβ) and aggregated tau protein are the proximate synaptotoxic species associated with Alzheimer's disease (AD). Anti-Aβ immunotherapy is a promising and advanced therapeutic strategy, but the precis
Externí odkaz:
https://doaj.org/article/b5e5d024a32647f4acc8c5e30db8eff6
Autor:
Zemin Wang, Ming Jin, Wei Hong, Wen Liu, David Reczek, Valentina N. Lagomarsino, Yuan Hu, Tim Weeden, Matthew P. Frosch, Tracy L. Young-Pearse, Laurent Pradier, Dennis Selkoe, Dominic M. Walsh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Despite ongoing debate, the amyloid β-protein (Aβ) remains the prime therapeutic target for the treatment of Alzheimer’s disease (AD). However, rational drug design has been hampered by a lack of knowledge about neuroactive Aβ. To help
Externí odkaz:
https://doaj.org/article/a44ed862eab649ab94c4fe38529e56d1
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Amyloid β-protein (Aβ) plays an initiating role in Alzheimer’s disease (AD), but only a small number of groups have studied Aβ extracted from human brain. Most prior studies have utilized synthetic Aβ peptides, but the relevance of these test t
Externí odkaz:
https://doaj.org/article/af7ee4075a3f402cadc6dc3a355e04a5
Autor:
David Mengel, Wen Liu, Robert J. Glynn, Dennis J. Selkoe, Andre Strydom, Florence Lai, H. Diana Rosas, Amy Torres, Vasiliki Patsiogiannis, Brian Skotko, Dominic M. Walsh
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2020)
Abstract Background Down syndrome (DS) is the most common genetic cause of Alzheimer’s disease (AD), but diagnosis of AD in DS is challenging due to the intellectual disability which accompanies DS. When disease-modifying agents for AD are approved
Externí odkaz:
https://doaj.org/article/765d7c94e9064dc89f729ff61c72457b
Autor:
Claire J. Sarell, Emma Quarterman, Daniel C.-M. Yip, Cassandra Terry, Andrew J. Nicoll, Jonathan D. F. Wadsworth, Mark A. Farrow, Dominic M. Walsh, John Collinge
Publikováno v:
Open Biology, Vol 7, Iss 11 (2017)
Mammalian prions cause lethal neurodegenerative diseases such as Creutzfeldt–Jakob disease (CJD) and consist of multi-chain assemblies of misfolded cellular prion protein (PrPC). Ligands that bind to PrPC can inhibit prion propagation and neurotoxi
Externí odkaz:
https://doaj.org/article/229b8c2701a0414b8a25fe465d116345
Autor:
Hilla Fogel, Samuel Frere, Oshik Segev, Shashank Bharill, Ilana Shapira, Neta Gazit, Tiernan O’Malley, Edden Slomowitz, Yevgeny Berdichevsky, Dominic M. Walsh, Ehud Y. Isacoff, Joel A. Hirsch, Inna Slutsky
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1560-1576 (2014)
Accumulation of amyloid-β peptides (Aβ), the proteolytic products of the amyloid precursor protein (APP), induces a variety of synaptic dysfunctions ranging from hyperactivity to depression that are thought to cause cognitive decline in Alzheimer
Externí odkaz:
https://doaj.org/article/1bb78f9cf1bf4953b0a4f2b76fc53c01
Autor:
Dominic M. Walsh, Dennis J. Selkoe
Publikováno v:
Current Opinion in Neurobiology. 61:116-124
Basic research on the biological mechanism of Alzheimer's disease has focused for decades on the age-related aggregation of the amyloid β-protein and its apparent downstream effects on microglia, astrocytes and neurons, including the posttranslation
Autor:
H. Diana Rosas, Dennis J. Selkoe, Robert J. Glynn, Vasiliki Patsiogiannis, Dominic M. Walsh, David Mengel, Andre Strydom, Amy Torres, Brian G. Skotko, Wen Liu, Florence Lai
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-11 (2020)
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy
Background Down syndrome (DS) is the most common genetic cause of Alzheimer’s disease (AD), but diagnosis of AD in DS is challenging due to the intellectual disability which accompanies DS. When disease-modifying agents for AD are approved, reliabl
Autor:
Francesc X. Guix, Grant T. Corbett, Diana J. Cha, Maja Mustapic, Wen Liu, David Mengel, Zhicheng Chen, Elena Aikawa, Tracy Young-Pearse, Dimitrios Kapogiannis, Dennis J. Selkoe, Dominic M. Walsh
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 3, p 663 (2018)
Progressive cerebral accumulation of tau aggregates is a defining feature of Alzheimer’s disease (AD). A popular theory that seeks to explain the apparent spread of neurofibrillary tangle pathology proposes that aggregated tau is passed from neuron
Externí odkaz:
https://doaj.org/article/c9f24393886640fea76449554131037f