Imaging and AI based chromatin biomarkers for diagnosis and therapy evaluation from liquid biopsies

Autor: Kiran Challa, Daniel Paysan, Dominic Leiser, Nadia Sauder, Damien C. Weber, G. V. Shivashankar

Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-13 (2023)

Abstract Multiple genomic and proteomic studies have suggested that peripheral blood mononuclear cells (PBMCs) respond to tumor secretomes and thus could provide possible avenues for tumor prognosis and treatment evaluation. We hypothesized that the

Externí odkaz: https://doaj.org/article/bea726c9a7a442469715f647d72a9656

Clinical Outcome After Pencil Beam Scanning Proton Therapy of Patients With Non-Metastatic Malignant and Benign Peripheral Nerve Sheath Tumors

Autor: Nicolas Bachmann, Dominic Leiser, Alessia Pica, Barbara Bachtiary, Damien C. Weber

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

ObjectivePeripheral nerve sheath tumors (PNSTs) commonly arise from peripheral nerve roots and grow locally invasive. Malignant PNSTs (mPNSTs) represent aggressive sarcomas of neural origin that can originate from PNSTs. Radiation therapy is commonly

Externí odkaz: https://doaj.org/article/57cb09d2c7dc4c3080f8b91c2a3f16f9

Correction: Role of caveolin-1 as a biomarker for radiation resistance and tumor aggression in lung cancer

Autor: Dominic Leiser, Santanu Samanta, Josh Strauss, John Eley, Michael Creed, Tami Kingsbury, Paul N. Staats, Binny Bhandary, Minjie Chen, Tijana Dukic, Sanjit Roy, Javed Mahmood, Zeljko Vujaskovic, Hem D. Shukla

Publikováno v: PLoS ONE, Vol 17, Iss 5 (2022)

Externí odkaz: https://doaj.org/article/0d8d20b97db64508b8e9aa79e63610ba

Outcome of proximal esophageal cancer after definitive combined chemo-radiation: a Swiss multicenter retrospective study

Autor: Evelyn Herrmann, Nando Mertineit, Berardino De Bari, Laura Hoeng, Francesca Caparotti, Dominic Leiser, Raphael Jumeau, Nikola Cihoric, Alexandra D. Jensen, Daniel M. Aebersold, Mahmut Ozsahin

Publikováno v: Radiation Oncology, Vol 12, Iss 1, Pp 1-12 (2017)

Abstract Objective To report oncological outcomes and toxicity rates, of definitive platin-based chemoradiadiationtherapy (CRT) in the management of proximal esophageal cancer. Methods We retrospectively reviewed the medical records of patients with

Externí odkaz: https://doaj.org/article/fe5f9ad6440a4248b2e63151ed34aee3

NTCP Modeling for High-Grade Temporal Radionecroses in a Large Cohort of Patients Receiving Pencil Beam Scanning Proton Therapy for Skull Base and Head and Neck Tumors

Autor: Christina Schröder, Andreas Köthe, Claudio De Angelis, Lucas Basler, Giovanni Fattori, Sairos Safai, Dominic Leiser, Antony J. Lomax, Damien C. Weber

Publikováno v: Schröder, C; Köthe, A; De Angelis, C; Basler, L; Fattori, G; Safai, S; Leiser, D; Lomax, A J; Weber, D C (2022). NTCP modelling for high-grade temporal radionecrosis in a large cohort of patients receiving pencil beam scanning proton therapy for skull base and head and neck tumors. International journal of radiation oncology, biology, physics, 113(2), pp. 448-455. Elsevier 10.1016/j.ijrobp.2022.01.047

PURPOSE/OBJECTIVES To develop a normal tissue complication probability (NTCP) model including clinical and dosimetric parameters for high-grade temporal lobe radionecroses (TRN) after pencil beam scanning (PBS) proton therapy (PT). MATERIALS/METHODS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f7b905325c3818d001d5405d02350d
https://doi.org/10.1016/j.ijrobp.2022.01.047