Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Dominic J. Hare"'
Autor:
James B. W. Hilton, Kai Kysenius, Jeffrey R. Liddell, Stephen W. Mercer, Bence Paul, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Dominic J. Hare, Blaine R. Roberts, Peter J. Crouch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The copper compound CuII(atsm) has progressed to phase 2/3 testing for treatment of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). CuII(atsm) is neuroprotective in mutant SOD1 mouse models of ALS where its activity is asc
Externí odkaz:
https://doaj.org/article/236516f7a4ca40819c0aeb1e8d9cbdfc
Autor:
Jeffrey R. Liddell, James B. W. Hilton, Kai Kysenius, Jessica L. Billings, Sara Nikseresht, Lachlan E. McInnes, Dominic J. Hare, Bence Paul, Stephen W. Mercer, Abdel A. Belaidi, Scott Ayton, Blaine R. Roberts, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Peter J. Crouch
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-21 (2024)
Abstract Background Ferroptosis is a form of regulated cell death characterised by lipid peroxidation as the terminal endpoint and a requirement for iron. Although it protects against cancer and infection, ferroptosis is also implicated in causing ne
Externí odkaz:
https://doaj.org/article/c1c1ef71cd304efcb8d9a959888a9cd7
Autor:
Francesca M. Alves, Kai Kysenius, Marissa K. Caldow, Justin P. Hardee, Jin D. Chung, Jennifer Trieu, Dominic J. Hare, Peter J. Crouch, Scott Ayton, Ashley I. Bush, Gordon S. Lynch, René Koopman
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 3, Pp 1541-1553 (2022)
Abstract Background Oxidative stress is implicated in the pathophysiology of Duchenne muscular dystrophy (DMD, caused by mutations in the dystrophin gene), which is the most common and severe of the muscular dystrophies. To our knowledge, the distrib
Externí odkaz:
https://doaj.org/article/da04fde3e0e44d6e87bd46e1112410fb
Autor:
Dominic J. Hare, Sabine Braat, Bárbara R. Cardoso, Christopher Morgan, Ewa A. Szymlek-Gay, Beverley-Ann Biggs
Publikováno v:
Systematic Reviews, Vol 8, Iss 1, Pp 1-10 (2019)
Abstract Background Direct supplementation or food fortification with iron are two public health initiatives intended to reduce the prevalence of iron deficiency (ID) and iron deficiency anaemia (IDA) in 4–24-month-old infants. In most high-income
Externí odkaz:
https://doaj.org/article/1820fff0f1eb403d93cb07c0fbd578fa
Autor:
David I. Finkelstein, Jessica L. Billings, Paul A. Adlard, Scott Ayton, Amelia Sedjahtera, Colin L. Masters, Simon Wilkins, David M. Shackleford, Susan A. Charman, Wojciech Bal, Izabela A. Zawisza, Ewa Kurowska, Andrew L. Gundlach, Sheri Ma, Ashley I. Bush, Dominic J. Hare, Philip A. Doble, Simon Crawford, Elisabeth C. L. Gautier, Jack Parsons, Penny Huggins, Kevin J. Barnham, Robert A. Cherny
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/99069d05543b4502a0f195c43761709b
Regular Physical Exercise Modulates Iron Homeostasis in the 5xFAD Mouse Model of Alzheimer’s Disease
Autor:
Irina Belaya, Nina Kucháriková, Veronika Górová, Kai Kysenius, Dominic J. Hare, Peter J. Crouch, Tarja Malm, Mustafa Atalay, Anthony R. White, Jeffrey R. Liddell, Katja M. Kanninen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8715 (2021)
Dysregulation of brain iron metabolism is one of the pathological features of aging and Alzheimer’s disease (AD), a neurodegenerative disease characterized by progressive memory loss and cognitive impairment. While physical inactivity is one of the
Externí odkaz:
https://doaj.org/article/aeaacfbfe76242f7b09354c6df43452a
Autor:
David I. Finkelstein, Jessica L. Billings, Paul A. Adlard, Scott Ayton, Amelia Sedjahtera, Colin L. Masters, Simon Wilkins, David M. Shackleford, Susan A. Charman, Wojciech Bal, Izabela A Zawisza, Ewa Kurowska, Andrew L. Gundlach, Sheri Ma, Ashley I. Bush, Dominic J. Hare, Philip A. Doble, Simon Crawford, Elisabeth CL. Gautier, Jack Parsons, Penny Huggins, Kevin J. Barnham, Robert A. Cherny
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-16 (2017)
Abstract Elevated iron in the SNpc may play a key role in Parkinson’s disease (PD) neurodegeneration since drug candidates with high iron affinity rescue PD animal models, and one candidate, deferirpone, has shown efficacy recently in a phase two c
Externí odkaz:
https://doaj.org/article/47a0547e87ee4b8299b2857d714adb6d
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Parkinson's disease is the second most common neurodegenerative disease. While age is the most significant risk factor, the exact cause of this disease and the most effective approaches to mitigation remain unclear. It has long been proposed that dop
Externí odkaz:
https://doaj.org/article/1df23c6b96a941a9a75edbcbda66fc82
Publikováno v:
Frontiers in Aging Neuroscience, Vol 5 (2013)
Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function. Redox cycling between ferrous and ferric iron is ut
Externí odkaz:
https://doaj.org/article/8dd7157f06d54a1194b1212395a45e5e
Autor:
Alan Rembach, Dominic J. Hare, Monica Lind, Christopher J. Fowler, Robert A. Cherny, Catriona McLean, Ashley I. Bush, Colin L. Masters, Blaine R. Roberts
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2013 (2013)
Alzheimer’s disease (AD) is the leading cause of dementia and represents a significant burden on the global economy and society. The role of transition metals, in particular copper (Cu), in AD has become of significant interest due to the dyshomeos
Externí odkaz:
https://doaj.org/article/9f59acaf8342418da0d0b1d0047d106e