Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Dominic J Wells"'
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0239467 (2020)
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the limitations of traditional in-situ hybridization (ISH) methodologies mean that the dynamics of dystrophin transcription remain poo
Externí odkaz:
https://doaj.org/article/5542f3e3218e4b2f88c55ac1cc7da0db
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211384 (2019)
The mdx mouse is the most widely-used animal model of the human disease Duchenne muscular dystrophy, and quantitative PCR analysis of gene expression in the muscles of this animal plays a key role in the study of pathogenesis and disease progression
Externí odkaz:
https://doaj.org/article/763a3240238a45b1a7ce96125497affd
Autor:
Nazanin Rahmani Kondori, Praveen Paul, Jacqueline P Robbins, Ke Liu, John C W Hildyard, Dominic J Wells, Jacqueline S de Belleroche
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188912 (2017)
Amyotrophic lateral sclerosis (ALS) is the most common adult-onset neuromuscular disorder characterised by selective loss of motor neurons leading to fatal paralysis. Current therapeutic approaches are limited in their effectiveness. Substantial adva
Externí odkaz:
https://doaj.org/article/96855e634541456ba79b1c37f2ee0c7a
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0147669 (2016)
Mice are one of the most commonly used laboratory animals, with an extensive array of disease models in existence, including for many neuromuscular diseases. The hindlimb is of particular interest due to several close muscle analogues/homologues to h
Externí odkaz:
https://doaj.org/article/1a779e4d1ef4400195ae6da84ed71d69
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91221 (2014)
Duchenne muscular dystrophy (DMD) is an X-linked, fatal muscle wasting disease for which there is currently no cure and limited palliative treatments. Poloxomer 188 (P188) is a tri-block copolymer that has been proposed as a potential treatment for c
Externí odkaz:
https://doaj.org/article/3c824d97a5a14f62b03c5a330cf89506
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24826 (2011)
A new conditionally immortal satellite cell-derived cell-line, H2K 2B4, was generated from the H2K(b)-tsA58 immortomouse. Under permissive conditions H2K 2B4 cells terminally differentiate in vitro to form uniform myotubes with a myogenic protein pro
Externí odkaz:
https://doaj.org/article/9868a3ca732548d7bdcad691c49f24f3
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24189 (2011)
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurological disorder characterized by selective degeneration of upper and lower motor neurons. The primary triggers for motor neuron degeneration are unknown but inflammation, oxidative stress and
Externí odkaz:
https://doaj.org/article/a9d4fe95e1c348ffb75d7fb182bcefa7
Autor:
Martin Brockington, Silvia Torelli, Paul S Sharp, Ke Liu, Sebahattin Cirak, Susan C Brown, Dominic J Wells, Francesco Muntoni
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14434 (2010)
BACKGROUND:LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of α-dystroglycan. Overexpression of LARGE induces hyperglycosylation of α-dystrogl
Externí odkaz:
https://doaj.org/article/4528d60e38da410791d5874fbea977db
Autor:
Dominique O. Riddell, John C. W. Hildyard, Rachel C. M. Harron, Frances Taylor-Brown, Joe N. Kornegay, Dominic J. Wells, Richard J. Piercy
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 12 (2023)
Externí odkaz:
https://doaj.org/article/c387e8a46e8b41748d428582fea41666
Publikováno v:
Wellcome Open Research, Vol 6 (2023)
Background: In addition to progressive, debilitating muscle degeneration, ~50% of patients with Duchenne muscular dystrophy (DMD) have associated cognitive and behavioural disorders secondary to deficiency of dystrophin protein in the brain. The brai
Externí odkaz:
https://doaj.org/article/62bd459e6dca438687855c58b9f1ef7f