Zobrazeno 1 - 10
of 12 269
pro vyhledávání: '"Dominic J"'
Autor:
Dominic J. Williamson, Nouédyn Baspin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-7 (2024)
Abstract Quantum computers require memories that are capable of storing quantum information reliably for long periods of time. The surface code is a two-dimensional quantum memory with code parameters that scale optimally with the number of physical
Externí odkaz:
https://doaj.org/article/3c871b18d768461283a87b451690fad2
Autor:
Dominic J. Romeo, Andrew M. George, Jonathan H. Sussman, Manisha Banala, Andrew Wiemken, Meagan Wu, Jinggang J. Ng, Jesse A. Taylor, Richard J. Schwab, Christopher M. Cielo, Jennifer M. Kalish
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-12 (2024)
Abstract Background An easy-to-use tool to objectively measure intraoral anatomy with meaningful clinical correlations may improve care for patients with Beckwith-Wiedemann syndrome (BWS), who commonly have symptomatic macroglossia. Methods Children
Externí odkaz:
https://doaj.org/article/c7609992021c4610bd3344d4bb275448
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Orientation or axial selectivity, the property of neurons in the visual system to respond preferentially to certain angles of visual stimuli, plays a pivotal role in our understanding of visual perception and information processing. This com
Externí odkaz:
https://doaj.org/article/b3042ca7448042dfa6b40309e2b7e403
Autor:
Fernando de Frutos, Juan Pablo Ochoa, Gregory Webster, Mark Jansen, Paloma Remior, Torsten B. Rasmussen, Maria Sabater‐Molina, Roberto Barriales‐Villa, Francesca Girolami, Sergi Cesar, M. Eugenia Fuentes‐Cañamero, Reyes Alvarez García‐Rovés, Karim Wahbi, Javier Limeres, Milos Kubanek, Martijn G. Slieker, Georgia Sarquella‐Brugada, Dominic J. Abrams, Dennis Dooijes, Fernando Domínguez, Pablo Garcia‐Pavia
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)
Background Although genetic variants in MYH7 are the most frequent cause of pediatric genetic dilated cardiomyopathy (DCM), there are no studies available describing this entity. We sought to describe clinical features, analyze variant location, and
Externí odkaz:
https://doaj.org/article/59e75968bc6945bab7fc180c951c9b2d
Autor:
Byungwook Kim, Luke Child Dabin, Mason Douglas Tate, Hande Karahan, Ahmad Daniel Sharify, Dominic J. Acri, Md Mamun Al-Amin, Stéphanie Philtjens, Daniel Curtis Smith, H. R. Sagara Wijeratne, Jung Hyun Park, Mathias Jucker, Jungsu Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract SPI1 was recently reported as a genetic risk factor for Alzheimer’s disease (AD) in large-scale genome-wide association studies. However, it is unknown whether SPI1 should be downregulated or increased to have therapeutic benefits. To inve
Externí odkaz:
https://doaj.org/article/e22ff5166e4e49748b9eeaf45df4118e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Critical periods are temporally-restricted, early-life windows when sensory experience remodels synaptic connectivity to optimize environmental input. In the Drosophila juvenile brain, critical period experience drives synapse elimination, w
Externí odkaz:
https://doaj.org/article/8225cef896694fd7bc71493e99ac83b6
Autor:
Chiara Prodani, Elaine E. Irvine, Alessandro Sardini, Hannah J. Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J. Withers, Mark A. Ungless, Matthias Merkenschlager, Amanda G. Fisher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract We tracked the consequences of in utero protein restriction in mice throughout their development and life course using a luciferase-based allelic reporter of imprinted Cdkn1c. Exposure to gestational low-protein diet (LPD) results in the ina
Externí odkaz:
https://doaj.org/article/81d158cc89d44bcea82892374ccb7f0f
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-33 (2024)
Abstract Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different tissues. Recombinant AAV (rAAV) has been engineer
Externí odkaz:
https://doaj.org/article/0d352d9c4b0c45b6a1cdc849a6677099
Autor:
James B. W. Hilton, Kai Kysenius, Jeffrey R. Liddell, Stephen W. Mercer, Bence Paul, Joseph S. Beckman, Catriona A. McLean, Anthony R. White, Paul S. Donnelly, Ashley I. Bush, Dominic J. Hare, Blaine R. Roberts, Peter J. Crouch
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The copper compound CuII(atsm) has progressed to phase 2/3 testing for treatment of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). CuII(atsm) is neuroprotective in mutant SOD1 mouse models of ALS where its activity is asc
Externí odkaz:
https://doaj.org/article/236516f7a4ca40819c0aeb1e8d9cbdfc
Publikováno v:
eLife, Vol 12 (2024)
The cerebellum contributes to a diverse array of motor conditions, including ataxia, dystonia, and tremor. The neural substrates that encode this diversity are unclear. Here, we tested whether the neural spike activity of cerebellar output neurons is
Externí odkaz:
https://doaj.org/article/1884904f9ba845f7aba263e501abd22a