Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dominic Gregor Hoch"'
Autor:
Nan Qiu, Chengsen Cui, Alexander Adibekian, Mingji Dai, Xianglin Yin, Jie-Qing Liu, Brendan G. Dwyer, Zhong-Jian Cai, Dominic Gregor Hoch, Daniel Abegg, Chang Liu
Publikováno v:
J Am Chem Soc
The curcusone natural products are complex diterpenes featuring a characteristic [6-7-5] tricyclic carbon skeleton similar to the daphnane and tigliane diterpenes. Among them, curcusones A-D demonstrated potent anticancer activity against a broad spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f97833ed70308311c6290d989200882
https://doi.org/10.1021/jacs.1c00557
https://doi.org/10.1021/jacs.1c00557
Autor:
Daniel Abegg, Dominic Gregor Hoch, Brendan G. Dwyer, Zhensheng Zhao, Dany Pechalrieu, Anton Shuster, Nan Qiu, Brittney Racioppo, Alexander Adibekian, Chao Wang
Publikováno v:
Angewandte Chemie International Edition. 60:3071-3079
Herein, we report arylazopyrazole ureas and sulfones as a novel class of photoswitchable serine hydrolase inhibitors and present a chemoproteomic platform for rapid discovery of optically controlled serine hydrolase targets in complex proteomes. Spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::986d8a5dc4741783cb50e5ef262922e1
https://doi.org/10.1002/anie.202011163
https://doi.org/10.1002/anie.202011163
Autor:
Daniel Abegg, Dominic Gregor Hoch, Alexander Adibekian, Jessica L. Childs-Disney, Sai Pradeep Velagapudi, Matthew G. Costales, Matthew D. Disney
Publikováno v:
Journal of the American Chemical Society. 141:2960-2974
A small molecule (1) with overlapping affinity for two microRNA (miRNA) precursors was used to inform design of a dimeric compound (2) selective for one of the miRNAs. In particular, 2 selectively targets the microRNA(miR)-515 hairpin precursor to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6f8667014b8ff71ffaaf27c2d1724b
https://doi.org/10.1021/jacs.8b10558
https://doi.org/10.1021/jacs.8b10558
Autor:
Jessica L. Childs-Disney, Yue Li, Ilyas Yildirim, Alexander Adibekian, Yoshio Nakai, Haruo Aikawa, Eric T. Wang, Matthew D. Disney, Tanya Khan, Matthew G. Costales, Daniel Abegg, Sai Pradeep Velagapudi, Dominic Gregor Hoch, Kye Won Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 117(5)
As the area of small molecules interacting with RNA advances, general routes to provide bioactive compounds are needed as ligands can bind RNA avidly to sites that will not affect function. Small-molecule targeted RNA degradation will thus provide a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34c3855a2d55d648be08c3c1f90f575
https://pubmed.ncbi.nlm.nih.gov/35471914
https://pubmed.ncbi.nlm.nih.gov/35471914
Autor:
Dominic Gregor Hoch, Alexander Adibekian, Li Wu, Brandon S. Martin, Zhong Yin Zhang, Mingji Dai, Daniel Abegg, Dexter C. Davis
Publikováno v:
Journal of the American Chemical Society. 140:17465-17473
Abiespiroside A (1), beshanzuenone C (2), and beshanzuenone D (3) belong to the Abies sesquiterpenoid family. Beshanzuenones C (2) and D (3) are isolated from the critically endangered Chinese fir tree species Abies beshanzuensis and demonstrated wea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276eb8c45108cbbcb869474ee2e12a4a
https://doi.org/10.1021/jacs.8b07652
https://doi.org/10.1021/jacs.8b07652
Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT
Publikováno v:
Angewandte Chemie: International Edition, Vol. 55, No 8 (2016) pp. 2911-2915
We present a novel chemical scaffold for cysteine-reactive covalent inhibitors. Chloromethyl triazoles (CMTs) are readily accessed in only two chemical steps, thus enabling the rapid optimization of the pharmacological properties of these inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1e68365f4610f29a6ad6251487b13c
https://doi.org/10.1002/anie.201511301
https://doi.org/10.1002/anie.201511301
Autor:
Dominic Gregor Hoch, Xiaojin Zhang, Howard Riezman, Dany Pechalrieu, Alexander Adibekian, J. Thomas Hannich, Chao Wang, Anton Shuster, Daniel Abegg, Qidong You, Brendan G. Dwyer
Publikováno v:
Cell Chemical Biology, Vol. 27, No 5 (2020) pp. 586-597.e12
Summary In this study, we identify the natural product gambogic acid as well as structurally related synthetic xanthones as first-in-class covalent inhibitors of the de novo sphingolipid biosynthesis. We apply chemoproteomics to determine that gambog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d505c0608d7824d55064d62263d94728
https://doi.org/10.1016/j.chembiol.2020.03.008
https://doi.org/10.1016/j.chembiol.2020.03.008
Publikováno v:
Chemical Communications, Vol. 54, No 36 (2018) pp. 4501-4512
Proteomic profiling using bioorthogonal chemical probes that selectively react with certain amino acids is now a widely used method in life sciences to investigate enzymatic activities, study posttranslational modifications and discover novel covalen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef027369a57a176633e6c83c25be67f
https://pubmed.ncbi.nlm.nih.gov/29645055
https://pubmed.ncbi.nlm.nih.gov/29645055
Autor:
Daniel Abegg, Giulio Gasparini, Alexander Adibekian, Dominic Gregor Hoch, Stefan Matile, Anton Shuster, Eline Bartolami
Publikováno v:
Journal of the American Chemical Society, Vol. 139, No 1 (2017) pp. 231-238
In this study, we demonstrate that appendage of a single asparagusic acid residue (AspA tag) is sufficient to ensure efficient cellular uptake and intracellular distribution of fully unprotected peptides. We apply this new delivery method to induce a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c4a4b5b7d0777c6bd2323d1e841e15
https://archive-ouverte.unige.ch/unige:90971
https://archive-ouverte.unige.ch/unige:90971
Autor:
Roman Lagoutte, Alexander Adibekian, Daniel Abegg, Nicolas Winssinger, Dominic Gregor Hoch, Christelle Serba
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature Communications, Vol. 7 (2016) P. 12470
Nature Commun
Nature Communications
Nature Communications, Vol. 7 (2016) P. 12470
Nature Commun
Herbal extracts containing sesquiterpene lactones have been extensively used in traditional medicine and are known to be rich in α,β-unsaturated functionalities that can covalently engage target proteins. Here we report synthetic methodologies to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f8b04f4f182b209649ec6f124e3f85
https://doi.org/10.1038/ncomms12470
https://doi.org/10.1038/ncomms12470