Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Dominic Ferber"'
Publikováno v:
ACS Omega, Vol 7, Iss 9, Pp 8158-8162 (2022)
Externí odkaz:
https://doaj.org/article/ad32543943bd472c8256563efd77a977
Autor:
Marius Monschke, Sina Müller, Jan Krönke, Izidor Sosič, Michael Gütschow, Dominic Ferber, Aleša Bricelj, Christian Steinebach, Yuen Lam Dora Ng, Karl G. Wagner, Robert Kuchta
Publikováno v:
ACS Med Chem Lett
[Image: see text] Proteolysis targeting chimeras (PROTACs) hijacking the cereblon (CRBN) E3 ubiquitin ligase have emerged as a novel paradigm in drug development. Herein we found that linker attachment points of CRBN ligands highly affect their aqueo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dc13fd34d1d549e06c0b71cf90a1c24
https://doi.org/10.1021/acsmedchemlett.1c00368
https://doi.org/10.1021/acsmedchemlett.1c00368
Autor:
Carina Lemke, Adéla Jílková, Dominic Ferber, Annett Braune, Anja On, Patrick Johe, Alena Zíková, Tanja Schirmeister, Michael Mareš, Martin Horn, Michael Gütschow
Publikováno v:
Chemistry – A European Journal. 28
Rhodesain is the major cysteine protease of the protozoan parasite Trypanosoma brucei and a therapeutic target for sleeping sickness, a fatal neglected tropical disease. We designed, synthesized and characterized a bimodal activity-based probe that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27d0522b3aa25a7d720c8994aa3d3b7
https://doi.org/10.1002/chem.202201636
https://doi.org/10.1002/chem.202201636