MYT1L deficiency impairs excitatory neuron trajectory during cortical development

Autor: Allen Yen, Simona Sarafinovska, Xuhua Chen, Dominic D. Skinner, Fatjon Leti, MariaLynn Crosby, Jessica Hoisington-Lopez, Yizhe Wu, Jiayang Chen, Zipeng A. Li, Kevin K. Noguchi, Robi D. Mitra, Joseph D. Dougherty

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract Mutations reducing the function of MYT1L, a neuron-specific transcription factor, are associated with a syndromic neurodevelopmental disorder. MYT1L is used as a pro-neural factor in fibroblast-to-neuron transdifferentiation and is hypothesi

Externí odkaz: https://doaj.org/article/641f235149614360b9fe7de9d43b9ff1

Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus

Autor: Ryan M. O'Connell, Dominic D Skinner, H. Atakan Ekiz, Thomas E. Lane, Colleen Stone, Amber R. Syage

Publikováno v: Journal of Virology
Journal of virology, vol 94, iss 24

Understanding the immunological mechanisms contributing to both host defense and disease following viral infection of the CNS is of critical importance given the increasing number of viruses that are capable of infecting and replicating within the ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672f2638e30998a74f79e444459b5e5b

CXCR2 Signaling and Remyelination in Preclinical Models of Demyelination

Autor: Dominic D Skinner, Thomas E. Lane

Publikováno v: DNA and cell biology, vol 39, iss 1
DNA Cell Biol

The chemokine receptor CXCR2 is a receptor for CXC chemokines, including CXCL1 and CXCL2. CXCR2 is expressed by resident cells of the central nervous system, including neurons, microglia, oligodendrocyte progenitor cells (OPCs), and oligodendrocytes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72738e65bf90c3703522aab0088b043a
https://escholarship.org/uc/item/5w79n334

Innate Immune Responses and Viral-Induced Neurologic Disease

Autor: Thomas E. Lane, Dominic D Skinner, Yuting Cheng

Publikováno v: Journal of Clinical Medicine, Vol 8, Iss 1, p 3 (2018)
Journal of Clinical Medicine
Journal of clinical medicine, vol 8, iss 1

Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by chronic neuroinflammation, axonal damage, and demyelination. Cellular components of the adaptive immune response are viewed as important in initiating formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321977b4b1016fb5da5387bef66d5f0d
https://www.mdpi.com/2077-0383/8/1/3

Chemokine CXCL10 and Coronavirus-Induced Neurologic Disease.

Autor: Skinner D; 1 Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah., Marro BS; 2 Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California., Lane TE; 1 Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah.; 3 Immunology, Inflammation and Infectious Disease Initiative, University of Utah School of Medicine, Salt Lake City, Utah.; 4 Neuroscience Initiative, University of Utah School of Medicine, Salt Lake City, Utah.

Publikováno v: Viral immunology [Viral Immunol] 2019 Jan/Feb; Vol. 32 (1), pp. 25-37. Date of Electronic Publication: 2018 Aug 15.