Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Dominic D G Owens"'
Autor:
Dominic D. G. Owens, Giorgio Anselmi, A. Marieke Oudelaar, Damien J. Downes, Alessandro Cavallo, Joe R. Harman, Ron Schwessinger, Akin Bucakci, Lucas Greder, Sara de Ornellas, Danuta Jeziorska, Jelena Telenius, Jim R. Hughes, Marella F. T. R. de Bruijn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
RUNX1 is a large and complex gene with two alternative promoters and multiple hematopoietic enhancers. Here the authors show that unlike smaller genes Runx1 becomes sub-compartmentalized during differentiation and gene activation. This subcompartment
Externí odkaz:
https://doaj.org/article/2c70bda05c964692b2499b46b84229b8
Autor:
Marcus A. Cheek, Aiping Dong, Renato Ferreira de Freitas, Dalia Barsyte-Lovejoy, Aliakbar Khalili Yazdi, Jinrong Min, Fengling Li, Victoria Vu, Albina Bolotokova, Lindsey I. James, Jack Greenblatt, Naimee Mehta, Irina K. Popova, David Dilworth, Ming Lei, Raquel Arminda Carvalho Machado, Ronan P Hanley, David Y Nie, Matthieu Schapira, Mengqi Zhou, Elisa Gibson, Cheryl H. Arrowsmith, Michael-Christopher Keogh, Suzanne Ackloo, Matthew R. Marunde, Mona Alqazzaz, Dmitri Kireev, Nathan W. Hall, Peter Brown, Abdellah Allali-Hassani, Sina Kazemzadeh, Edyta Marcon, Tigran M. Abramyan, Dominic D G Owens, Yanli Liu, Magdalena M. Szewczyk, Matthew J. Meiners, Irene Chau, Su Qin, Masoud Vedadi
Publikováno v:
Nat Chem Biol
Nuclear receptor-binding SET domain-containing 2 (NSD2) is the primary enzyme responsible for the dimethylation of lysine 36 of histone 3 (H3K36), a mark associated with active gene transcription and intergenic DNA methylation. In addition to a methy
Autor:
Danuta M. Jeziorska, Hughes, de Bruijn Mf, Jelena Telenius, Harman, Damien J. Downes, Andrea Cavallo, Lucas Greder, Bucakci A, Ron Schwessinger, De Ornellas S, Dominic D G Owens, Giorgio Anselmi, A M Oudelaar
Publikováno v:
Nature Communications
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The transcription factor RUNX1 is a critical regulator of developmental hematopoiesis and is frequently disrupted in leukemia. Runx1 is a large, complex gene that is expressed from two alternative promoters under the spatiotemporal control of multipl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab771d77e970017782fd87ea8de1292
https://hdl.handle.net/21.11116/0000-000A-2BF1-621.11116/0000-000A-2BF4-3
https://hdl.handle.net/21.11116/0000-000A-2BF1-621.11116/0000-000A-2BF4-3
Autor:
Joe Harman, Peter J. McHugh, Lucas Greder, Dominic D G Owens, Vincent Frontera, Philip Hublitz, Marella F. T. R. de Bruijn, Lydia Teboul, Alasdair J Allan, Akin Bucakci, Adam Caulder, Gemma F. Codner
Publikováno v:
Nucleic Acids Research
The CRISPR system is widely used in genome editing for biomedical research. Here, using either dual paired Cas9D10A nickases or paired Cas9 nuclease we characterize unintended larger deletions at on-target sites that frequently evade common genotypin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03dd16dfb3c903caac34c998df1bb403
https://doi.org/10.1093/nar/gkz459
https://doi.org/10.1093/nar/gkz459
Autor:
Jim R. Hughes, Andrew Jarratt, Lucas Greder, Damien J. Downes, Marella F. T. R. de Bruijn, Christina Rode, Dominic D G Owens, Vincent Frontera, Joe Harman
Publikováno v:
Experimental Hematology. 64:S91
Publikováno v:
Annual Review of Cancer Biology; 2024, Vol. 8 Issue 1, p373-393, 21p
Publikováno v:
Cancer Weekly; 8/6/2024, p628-628, 1p
Autor:
Owens, Dominic D. G., Anselmi, Giorgio, Oudelaar, A. Marieke, Downes, Damien J., Cavallo, Alessandro, Harman, Joe R., Schwessinger, Ron, Bucakci, Akin, Greder, Lucas, de Ornellas, Sara, Jeziorska, Danuta, Telenius, Jelena, Hughes, Jim R., de Bruijn, Marella F. T. R.
Publikováno v:
Nature Communications; 2/9/2022, Vol. 13 Issue 1, p1-15, 15p
Autor:
Owens, Dominic D G, Caulder, Adam, Frontera, Vincent, Harman, Joe R, Allan, Alasdair J, Bucakci, Akin, Greder, Lucas, Codner, Gemma F, Hublitz, Philip, McHugh, Peter J, Teboul, Lydia, de Bruijn, Marella F T R
Publikováno v:
Nucleic Acids Research; 8/22/2019, Vol. 47 Issue 14, p7402-7417, 16p