Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dominic C. M. Ng"'
Autor:
Edward Lau, Quan Cao, Maggie P. Y. Lam, Jie Wang, Dominic C. M. Ng, Brian J. Bleakley, Jessica M. Lee, David A. Liem, Ding Wang, Henning Hermjakob, Peipei Ping
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Transcriptome data provide only a partial picture of disease states. Here, via integration of transcript-, protein abundance and protein turnover data for a mouse model of cardiac hypertrophy, the authors uncover additional disease gene signatures, a
Externí odkaz:
https://doaj.org/article/735fc1b56e0a42518ad0a64c538beba9
Publikováno v:
Journal of Molecular and Cellular Cardiology. 121:163-172
Cardiac remodeling (CR) is a complex dynamic process common to many heart diseases. CR is characterized as a temporal progression of global adaptive and maladaptive perturbations. The complex nature of this process clouds a comprehensive understandin
Autor:
Brian J. Bleakley, David A. Liem, Jie Wang, Peipei Ping, Maggie P.Y. Lam, Ding Wang, Henning Hermjakob, Jessica M. Lee, Quan Cao, Dominic C. M. Ng, Edward Lau
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications
Transcript abundance and protein abundance show modest correlation in many biological models, but how this impacts disease signature discovery in omics experiments is rarely explored. Here we report an integrated omics approach, incorporating measure
Autor:
Jie Wang, Yibin Wang, Jessica M. Lee, Peipei Ping, John R. Yates, Dominic C. M. Ng, Howard Choi, Bilal Mirza, Ding Wang
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Sarah B. Scruggs, Bilal Mirza, Jie Wang, Neo Christopher Chung, Peipei Ping, Dominic C. M. Ng, Anders O. Garlid, Ding Wang, Howard Choi, Quan Cao
Publikováno v:
Journal of proteome research. 17(12)
Cysteine oxidative modification of cellular proteins is crucial for many aspects of cardiac hypertrophy development. However, integrated dissection of multiple types of cysteine oxidative post-translational modifications (O-PTM) of proteomes in cardi
Maladaptive cardiac remodeling (MCR) is a complex dynamic process common to many heart diseases. MCR is characterized as a temporal progression of global adaptive and maladaptive perturbations. The complex nature of this process clouds a comprehensiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50305e035f7ad43022a51258710f97e6
https://doi.org/10.1101/270959
https://doi.org/10.1101/270959
Autor:
Maggie P.Y. Lam, Ding Wang, Howard Choi, Haomin Li, John R. Yates, Peipei Ping, Dominic C. M. Ng, Edward Lau, Ivette Zelaya, David Meyer, Caiyun Fang, Nobel C. Zong
Publikováno v:
PROTEOMICS - Clinical Applications. 8:590-594
Purpose Altered proteasome functions are associated with multiple cardiomyopathies. While the proteasome targets polyubiquitinated proteins for destruction, it itself is modifiable by ubiquitination. We aim to identify the exact ubiquitination sites
Autor:
Maggie P.Y. Lam, Chenguang Liu, Martin Cadeiras, Dominic C. M. Ng, Edward Lau, Jason D. Tabaraki, Ding Wang, Yibin Wang, Peipei Ping, David A. Liem, Xiangbo Liang, Brian J. Bleakley, Allen K. Kim, Mario C. Deng
Publikováno v:
The Journal of clinical investigation, vol 124, iss 4
Protein temporal dynamics play a critical role in time-dimensional pathophysiological processes, including the gradual cardiac remodeling that occurs in early-stage heart failure. Methods for quantitative assessments of protein kinetics are lacking,
Autor:
Jie Wang, Bilal Mirza, Ding Wang, Dominic C. M. Ng, Peipei Ping, Howard Choi, Jessica G. H. Lee, Rajasekaran Namakkal Soorappan
Publikováno v:
Journal of Molecular and Cellular Cardiology. 124:103
Autor:
Ivan K. Chu, Dominic C. M. Ng, A. S.-C. Cheung, J. C. Yves Le Blanc, H. F. Pang, James W. Hager, De-Cai Fang, Cheuk-Kuen Lai
Publikováno v:
Rapid Communications in Mass Spectrometry. 27:1119-1127
Rationale We implemented, for the first time, laser-induced dissociation (LID) within a modified hybrid linear ion trap mass spectrometer, QTrap, while preserving the original scanning capabilities and routine performance of the instrument. Methods P