Výsledky vyhledávání - "Dominic C. Borie"

Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7monoclonal antibody, for treating inflammatory bowel diseases

Publikováno v: British Journal of Clinical Pharmacology. 78:1315-1333

AIMS AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration were evaluated in a randomized, double-blind, placebo-controlled study. METHODS Healthy mal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4affc6406b420c1a3ccb1e05e144e99
https://doi.org/10.1111/bcp.12418

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Prediction of clinical pharmacokinetics of AMG 181, a human anti-α4β7 monoclonal antibody for treating inflammatory bowel diseases

Autor: John A. Wisler, Peter J. Prince, Kathleen Köck, Hailing Hsu, Kai O. Reynhardt, Wei-Jian Pan, Dominic C. Borie, William A. Rees, Zhigang Yu, Hong Li, David H. Salinger

Publikováno v: Pharmacology Research & Perspectives

The purpose of this study was to predict a safe starting dose of AMG 181, a human anti-α 4 β 7 antibody for treating inflammatory bowel diseases, based on cynomolgus monkey pharmacokinetic (PK) and pharmacodynamic (PD) data. A two-compartment model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7681a5910c5d5de36930954856ae429d
http://europepmc.org/articles/PMC4317229

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Quantitative Analysis of the Immunosuppressant CP-690,550 in Whole Blood by Column-Switching High-Performance Liquid Chromatography and Mass Spectrometry Detection

Autor: Paul S. Changelian, Dominic C. Borie, Ricardo T. Paniagua, Andrew Campbell, Bruce A. Reitz, Chandra Prakash

Publikováno v: Therapeutic Drug Monitoring. 27:608-616

A fast and accurate method to quantify the new immunosuppressive JAK3 inhibitor CP-690,550 in whole blood using a dual-pump liquid chromatography-liquid chromatography-mass spectrometry (LC/LC-MS) system was developed and validated in nonhuman primat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a49d39e0a9249dcb1173a7d26a14d5
https://doi.org/10.1097/01.ftd.0000170030.13702.04

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Immunosuppressive effects of surgery assessed by flow cytometry in nonhuman primates after nephrectomy

Autor: Dominic C. Borie, Randall E. Morris, Bernard Hausen, Mario Stalder, Tudor Bîrsan

Publikováno v: Transplant International. 18:1158-1165

Despite previous studies suggesting that surgery cause immune suppression, the underlying biologic mechanisms have not been studied using advanced immune function assays. Unilateral nephrectomy was performed in nonhuman primates. Blood was collected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f6b3a933028c50437d3f9493083160
https://doi.org/10.1111/j.1432-2277.2005.00119.x

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Identification of the VH genes encoding xenoantibodies in non-immunosuppressed rhesus monkeys

Autor: Ivan Todorov, Yoko Mullen, Annette Kleihauer, Joanne L. Zahorsky-Reeves, Insiyyah Patanwala, Mary Kearns-Jonker, Irina Shulkin, Andrew E. Kyles, Vaughn A. Starnes, Clare R. Gregory, Dominic C. Borie

Publikováno v: Immunology. 116:89-102

The major immunological barrier that prevents the use of wild-type pig xenografts as an alternative source of organs for human xenotransplantation is antibody-mediated rejection. In this study, we identify the immunoglobulin variable region heavy (Ig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a548dd58dc66dc684447da991f81a317
https://doi.org/10.1111/j.1365-2567.2005.02204.x

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Effects of the kinase inhibitor CGP41251 (PKC 412) on lymphocyte activation and TNF-α production

Autor: Ming-Sing Si, Dominic C. Borie, Bruce A. Reitz

Publikováno v: International Immunopharmacology. 5:1141-1149

CGP41251 is a serine/threonine and tyrosine kinase inhibitor that is a novel anticancer agent. Because the kinases that CGP41251 inhibits play important roles in T lymphocyte activation, we hypothesized that this compound may have useful immunomodula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7ca9edc5a14e43d989f0ff5e1a77c3
https://doi.org/10.1016/j.intimp.2005.02.012

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A new modality for immunosuppression: targeting the JAK/STAT pathway

Autor: Dominic C. Borie, Paul S. Changelian, Marko Pesu, John J. O'Shea

Publikováno v: Nature Reviews Drug Discovery. 3:555-564

Thousands of organs are transplanted each year and millions of people suffer from autoimmune diseases, which creates a need for an armamentarium of immunosuppressive drugs. Unfortunately, immunosuppressants have unwanted side effects owing, in part,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5226e03e2668a38b80bafa99a5e1ac0d
https://doi.org/10.1038/nrd1441

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In vitro evaluation of the effects of candidate immunosuppressive drugs: flow cytometry and quantitative real-time PCR as two independent and correlated read-outs

Autor: Randall E. Morris, Bruce A. Reitz, Dominic C. Borie, Sally Zhang, Ann Ha, Mona G. Flores, Bari Holm

Publikováno v: Journal of Immunological Methods. 289:123-135

Background : Immune monitoring may use flow cytometry or molecular biology techniques. Flow cytometry assays cells that are phenotypically characterized, whereas TaqMan® RT-PCR starts with RNA extraction from unfractionated heterogeneous cell popula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bbe1eca972e56e4249be486ab3c489c
https://doi.org/10.1016/j.jim.2004.04.002

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