Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dominic Boudreau"'
Autor:
Louis-Etienne Lorenzo, Antoine G. Godin, Francesco Ferrini, Karine Bachand, Isabel Plasencia-Fernandez, Simon Labrecque, Alexandre A. Girard, Dominic Boudreau, Irenej Kianicka, Martin Gagnon, Nicolas Doyon, Alfredo Ribeiro-da-Silva, Yves De Koninck
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-23 (2020)
Disinhibition in the dorsal horn of the spinal cord may contribute to chronic pain. Here the authors show that, despite a paradoxical increase in α2/α3 subunits of the GABAA receptor in a neuropathic pain model, inhibition eventually fails due to K
Externí odkaz:
https://doaj.org/article/7e8316d0d5b2495c8bdcf34c648c6da7
Autor:
Martin Gagnon, Alexandre A. Girard, Antoine G. Godin, Yves De Koninck, Alfredo Ribeiro-da-Silva, Louis-Etienne Lorenzo, Francesco Ferrini, Isabel Plasencia-Fernandez, Simon Labrecque, Nicolas Doyon, Irenej Kianicka, Dominic Boudreau, Karine Bachand
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-23 (2020)
Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994fd0e1744f15feeb46ff4d842b360b
http://hdl.handle.net/2318/1727795
http://hdl.handle.net/2318/1727795
Autor:
Louis-Etienne, Lorenzo, Antoine G, Godin, Francesco, Ferrini, Karine, Bachand, Isabel, Plasencia-Fernandez, Simon, Labrecque, Alexandre A, Girard, Dominic, Boudreau, Irenej, Kianicka, Martin, Gagnon, Nicolas, Doyon, Alfredo, Ribeiro-da-Silva, Yves, De Koninck
Publikováno v:
Nature Communications
Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported, raising questions on the best target to produce analgesia. Here, we show that nerve injury is as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cb6e8982c3856c4d1139045d950da51
https://pubmed.ncbi.nlm.nih.gov/32054836
https://pubmed.ncbi.nlm.nih.gov/32054836
Autor:
Paul Isenring, Mariève Jacob-Wagner, Marc J. Bergeron, Jeffrey A. M. Coull, Guillaume Lavertu, Lionel Dumas, Sasmita Tripathy, Giorgio Attardo, Annie Castonguay, Irenej Kianicka, Christian Tardif, Karine Bachand, Robert P. Bonin, Martin Gagnon, Jimena Perez-Sanchez, Yves De Koninck, Bin Wang, Isabelle Valade, Dominic Boudreau
Publikováno v:
Nature Medicine. 19:1524-1528
The K(+)-Cl(-) cotransporter KCC2 is responsible for maintaining low Cl(-) concentration in neurons of the central nervous system (CNS), which is essential for postsynaptic inhibition through GABA(A) and glycine receptors. Although no CNS disorders h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6775e4833793b5f96edcd0fe890f15f6
https://doi.org/10.1038/nm.3356
https://doi.org/10.1038/nm.3356
Autor:
Yoichi Miyahara, Peter Grutter, Margaret H. Magdesian, Ricardo Sanz, Alyson E. Fournier, Megumi Mori, G. Monserratt Lopez-Ayon, Yves De Koninck, Christopher J. Barrett, Dominic Boudreau, Alexis Goulet-Hanssens
CNS injury may lead to permanent functional deficits because it is still not possible to regenerate axons over long distances and accurately reconnect them with an appropriate target. Using rat neurons, microtools, and nanotools, we show that new, fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0a8e077eac14139e1ab05d142f73e4
https://europepmc.org/articles/PMC4719026/
https://europepmc.org/articles/PMC4719026/
Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
Autor:
Jeffrey A. M. Coull, Dominic Boudreau, Attila Sik, Francine Nault, Karine Bachand, Yves De Koninck, Paul De Koninck, Steven A. Prescott
Publikováno v:
Nature. 424:938-942
Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn of the spinal cord is a crucial substrate for chronic pain syndromes. However, the nature of the mechanisms that underlie such disinhibition has remained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc52981e09aa356171d98916cfcd5e15
https://doi.org/10.1038/nature01868
https://doi.org/10.1038/nature01868
Autor:
Jeffrey A. M. Coull, Matilde Cordero-Erausquin, Dominic Boudreau, Yves De Koninck, Matthias Rolland
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(42)
A deficit in inhibition in the spinal dorsal horn has been proposed to be an underlying cause of the exaggerated cutaneous sensory reflexes observed in newborn rats. However, the developmental shift in transmembrane anion gradient, potentially affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570a578227c1375c731b9b508c4197ef
https://pubmed.ncbi.nlm.nih.gov/16237166
https://pubmed.ncbi.nlm.nih.gov/16237166
Autor:
Simon Beggs, Claude Gravel, Kazuhide Inoue, Dominick Boivin, Makoto Tsuda, Yves De Koninck, Michael W. Salter, Jeffrey A. M. Coull, Dominic Boudreau
Publikováno v:
Nature. 438(7070)
Neuropathic pain that occurs after peripheral nerve injury depends on the hyperexcitability of neurons in the dorsal horn of the spinal cord. Spinal microglia stimulated by ATP contribute to tactile allodynia, a highly debilitating symptom of pain in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d19c722bcf8d470b634ac33d001b35
https://pubmed.ncbi.nlm.nih.gov/16355200
https://pubmed.ncbi.nlm.nih.gov/16355200