Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Dominic, Salois"'
Autor:
Xuehong Luo, Xiao Hong Yu, Pourashraf Mehrnaz, Sanjay Srivastava, Dominic Salois, Cheng Yun-Xing, Kemal Payza, Christopher Walpole, Etienne Lessard, Stephane St-Onge, Tomaszewski Miroslaw
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1619-1624
An oral, peripherally restricted CB1/CB2 agonist could provide an interesting approach to treat chronic pain by harnessing the analgesic properties of cannabinoids but without the well-known central side effects. γ-Carbolines are a novel class of po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70c2a778db169330114c41d0ed05f33
https://doi.org/10.1016/j.bmcl.2011.12.124
https://doi.org/10.1016/j.bmcl.2011.12.124
Autor:
Martin Coupal, Paul Jones, Lejla Hodzic, Wenhau Xiao, Edward Roberts, Andrew Griffin, Daniel Delorme, Dominic Salois, Maryse Labarre, Stephane St-Onge, Christopher Walpole, Jamie Boulet, Lars Gawell, Rico Lavoie, Joanne Butterworth, William Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5994-5998
We have investigated a series of phenolic diaryl amino piperidine delta opioid receptor agonists, establishing the importance of the phenol functional group and substitution on the piperdine nitrogen for delta agonist activity and selectivity versus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309cc40e144f4ea22f0ebf8874c89c2d
https://doi.org/10.1016/j.bmcl.2009.09.072
https://doi.org/10.1016/j.bmcl.2009.09.072
Publikováno v:
Biology of Reproduction. 61:288-297
BSP-A1, BSP-A2, BSP-A3, and BSP-30-kDa are four major proteins of bovine seminal plasma (BSP protein family). These heparin- and phosphatidylcholine-binding proteins potentiate the capacitation of spermatozoa. Here we determined the complete sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c11821752bd45d8e1aa354d8a65fc04
https://doi.org/10.1095/biolreprod61.1.288
https://doi.org/10.1095/biolreprod61.1.288
Autor:
Marie Roumi, Dominic Salois, Christopher Walpole, Lynda Adam, William Brown, Mylene Gosselin, Pierre-Emmanuel Morin, Andrew Griffin, Martin Coupal
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(21)
We have investigated phenol replacements in a series of diaryl amino piperidine delta opioid agonists. From this study we have demonstrated that the hydroxy functional group can be replaced with a primary amide group, giving enhanced activity at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4509e8ae81550e436ca52392014d70e4
https://pubmed.ncbi.nlm.nih.gov/19800790
https://pubmed.ncbi.nlm.nih.gov/19800790
Autor:
Daniel, Pagé, Elise, Balaux, Luc, Boisvert, Ziping, Liu, Claire, Milburn, Maxime, Tremblay, Zhongyong, Wei, Simon, Woo, Xuehong, Luo, Yun-Xing, Cheng, Hua, Yang, Sanjay, Srivastava, Fei, Zhou, William, Brown, Miroslaw, Tomaszewski, Christopher, Walpole, Leila, Hodzic, Stéphane, St-Onge, Claude, Godbout, Dominic, Salois, Kemal, Payza, Keymal, Payza
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(13)
The preparation and evaluation of a novel class of CB2 agonists based on a benzimidazole moiety are reported. They showed binding affinities up to 1 nM towards the CB2 receptor with partial to full agonist potencies. They also demonstrated good to ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b38faeba6c5ce18da2d54a009c6fb34
https://pubmed.ncbi.nlm.nih.gov/18522867
https://pubmed.ncbi.nlm.nih.gov/18522867
Autor:
Daniel Pagé, Elise Balaux, Luc Boisvert, Ziping Liu, Claire Milburn, Maxime Tremblay, Zhongyong Wei, Simon Woo, Xuehong Luo, Yun-Xing Cheng, Hua Yang, Sanjay Srivastava, Fei Zhou, William Brown, Miroslaw Tomaszewski, Christopher Walpole, Leila Hodzic, Stéphane St-Onge, Claude Godbout, Dominic Salois, Kemal Payza
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4914
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cd1d6c005cb53bc628487147519a81f
https://doi.org/10.1016/j.bmcl.2008.07.104
https://doi.org/10.1016/j.bmcl.2008.07.104