Composition and diversity analysis of the lung microbiome in patients with suspected ventilator-associated pneumonia

Autor: Dominic Fenn, Mahmoud I. Abdel-Aziz, Pouline M. P. van Oort, Paul Brinkman, Waqar M. Ahmed, Timothy Felton, Antonio Artigas, Pedro Póvoa, Ignacio Martin-Loeches, Marcus J. Schultz, Paul Dark, Stephen J. Fowler, Lieuwe D. J. Bos, The BreathDx Consortium

Publikováno v: Critical Care, Vol 26, Iss 1, Pp 1-12 (2022)

Abstract Background Ventilator-associated pneumonia (VAP) is associated with high morbidity and health care costs, yet diagnosis remains a challenge. Analysis of airway microbiota by amplicon sequencing provides a possible solution, as pneumonia is c

Externí odkaz: https://doaj.org/article/4b8ee398aae44593994132da58b61a86

Validation of volatile metabolites of pulmonary oxidative injury: a bench to bedside study

Autor: Dominic Fenn, Thijs A. Lilien, Laura A. Hagens, Marry R. Smit, Nanon F.L. Heijnen, Anita M. Tuip-de Boer, Anne H. Neerincx, Korneliusz Golebski, Dennis C.J.J. Bergmans, Ronny M. Schnabel, Marcus J. Schultz, Anke H. Maitland-van der Zee, Paul Brinkman, Lieuwe D.J. Bos

Publikováno v: ERJ Open Research, Vol 9, Iss 2 (2023)

Background Changes in exhaled volatile organic compounds (VOCs) can be used to discriminate between respiratory diseases, and increased concentrations of hydrocarbons are commonly linked to oxidative stress. However, the VOCs identified are inconsist

Externí odkaz: https://doaj.org/article/4ad35999d3744212916af4e1309aa61f

Comparison of microbial composition of cough swabs and sputum for pathogen detection in patients with cystic fibrosis

Autor: Renate Kos, Anne H. Neerincx, Josje Altenburg, Paul Brinkman, Mahmoud I. Abdel-Aziz, Suzanne W J Terheggen-Lagro, Eric G. Haarman, Anke H. Maitland-van der Zee, Dominic Fenn, Lieuwe D. J. Bos, Els J.M. Weersink

Publikováno v: Journal of Cystic Fibrosis, 21(1), 52-60. Elsevier
Journal of cystic fibrosis. Elsevier
Fenn, D, Abdel-Aziz, M I, Brinkman, P, Kos, R, Neerincx, A H, Altenburg, J, Weersink, E, Haarman, E G, Terheggen-Lagro, S W J, Maitland-van der Zee, A H, Amsterdam mucociliary clearance disease research group & Bos, L D J 2022, ' Comparison of microbial composition of cough swabs and sputum for pathogen detection in patients with cystic fibrosis ', Journal of Cystic Fibrosis, vol. 21, no. 1, pp. 52-60 . https://doi.org/10.1016/j.jcf.2021.08.031

Background With the continued advancement of CFTR modulator therapies there is likely to be a burgeoning population of adult cystic fibrosis (CF) patients unable to expectorate sputum. Consequently, the detection and surveillance of pulmonary colonis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e871219dbc701dc5b581617e467b2a16
https://doi.org/10.1016/j.jcf.2021.08.031

Exhaled Volatile Organic Compounds for Early Prediction of Bronchopulmonary Dysplasia in Infants Born Preterm

Autor: Michelle Romijn, Anton H. van Kaam, Dominic Fenn, Lieuwe D. Bos, Chris H.P. van den Akker, Martijn J.J. Finken, Joost Rotteveel, Julia Cerullo, Paul Brinkman, Wes Onland

Publikováno v: Journal of pediatrics. Mosby Inc.
The Journal of Pediatrics. Mosby Inc.
Romijn, M, van Kaam, A H, Fenn, D, Bos, L D, van den Akker, C H P, Finken, M J J, Rotteveel, J, Cerullo, J, Brinkman, P & Onland, W 2023, ' Exhaled Volatile Organic Compounds for Early Prediction of Bronchopulmonary Dysplasia in Infants Born Preterm ', The Journal of Pediatrics, vol. 257, 113368 . https://doi.org/10.1016/j.jpeds.2023.02.014
Journal of Pediatrics. Mosby Inc.

Objective(s): To investigate the predictive performances of exhaled breath volatile organic compounds (VOCs) for development of bronchopulmonary dysplasia (BPD) in infants born preterm. Methods: Exhaled breath was collected from infants born

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e88fc8c7786e9ce22f7a3cc93f82849
https://pure.amc.nl/en/publications/exhaled-volatile-organic-compounds-for-early-prediction-of-bronchopulmonary-dysplasia-in-infants-born-preterm(7154a960-8033-4d6d-b36d-f9d72c74f3cd).html