Applicability of a computational design approach for synthetic riboswitches

Autor: Domin, Gesine, Findeiß, Sven, Wachsmuth, Manja, Will, Sebastian, Stadler, Peter F., Mörl, Mario

Publikováno v: Nucleic Acids Research, 2016 doi: 10.1093/nar/gkw1267

Riboswitches have gained attention as tools for synthetic biology, since they enable researchers to reprogram cells to sense and respond to exogenous molecules. In vitro evolutionary approaches produced numerous RNA aptamers that bind such small liga

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Applicability of a computational design approach for synthetic riboswitches.

Autor: Domin G; Leipzig University, Institute for Biochemistry, 04103 Leipzig, Germany., Findeiß S; University of Vienna, Research Group Bioinformatics and Computational Biology, Faculty of Computer Science, A-1090 Vienna, Austria.; University of Vienna, Institute for Theoretical Chemistry, A-1090 Vienna, Austria., Wachsmuth M; Leipzig University, Institute for Biochemistry, 04103 Leipzig, Germany., Will S; Leipzig University, Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, 04107 Leipzig, Germany., Stadler PF; University of Vienna, Institute for Theoretical Chemistry, A-1090 Vienna, Austria.; Leipzig University, Bioinformatics Group, Department of Computer Science and Interdisciplinary Center for Bioinformatics, 04107 Leipzig, Germany.; Max Planck Institute for Mathematics in the Science, 04103 Leipzig, Germany.; Fraunhofer Institute for Cell Therapy and Immunology, 04103 Leipzig, Germany.; Santa Fe Institute, Santa Fe NM 87501, USA., Mörl M; Leipzig University, Institute for Biochemistry, 04103 Leipzig, Germany.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2017 Apr 20; Vol. 45 (7), pp. 4108-4119.