Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Domhnall McHugh"'
Autor:
Imanol Duran, Joaquim Pombo, Bin Sun, Suchira Gallage, Hiromi Kudo, Domhnall McHugh, Laura Bousset, Jose Efren Barragan Avila, Roberta Forlano, Pinelopi Manousou, Mathias Heikenwalder, Dominic J. Withers, Santiago Vernia, Robert D. Goldin, Jesús Gil
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Cellular senescence is a stress response with broad pathophysiological implications. Senotherapies can induce senescence to treat cancer or eliminate senescent cells to ameliorate ageing and age-related pathologies. However, the success of s
Externí odkaz:
https://doaj.org/article/5c897b7121a9453294556dca1837ca68
Autor:
Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Diran Herebian, Mohammad M. Karimi, Elaine E. Irvine, Domhnall McHugh, Anne T. Schneider, Mihael Vucur, Verena Keitel, Jesús Gil, Dominic J. Withers, Tom Luedde, Mathias Heikenwalder
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 875-878 (2022)
Externí odkaz:
https://doaj.org/article/e280f4386f824a5c900ac7be2676e8ec
Autor:
Verena Wagner, Jesús Gil, Joaquim Pombo, Gopuraja Dharmalingam, Johannes Zuber, Jean-Baptiste Vannier, Sharon Brookes, Andrew J. Innes, Rosa Maria Porreca, Domhnall McHugh, Ramón García-Escudero, Bin Sun, Santiago Vernia
Publikováno v:
Genes & Development
Senescence is a key barrier to neoplastic transformation. To identify senescence regulators relevant to cancer, we screened a genome-wide shRNA library. Here, we describe exportin 7 (XPO7) as a novel regulator of senescence and validate its function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb788261ef3d153026b00de3d6ad5719
https://doi.org/10.1101/gad.343269.120
https://doi.org/10.1101/gad.343269.120
Autor:
Andrew J, Innes, Bin, Sun, Verena, Wagner, Sharon, Brookes, Domhnall, McHugh, Joaquim, Pombo, Rosa María, Porreca, Gopuraja, Dharmalingam, Santiago, Vernia, Johannes, Zuber, Jean-Baptiste, Vannier, Ramón, García-Escudero, Jesús, Gil
Publikováno v:
Genes Dev
Senescence is a key barrier to neoplastic transformation. To identify senescence regulators relevant to cancer, we screened a genome-wide shRNA library. Here, we describe exportin 7 (XPO7) as a novel regulator of senescence and validate its function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bd04db71327dbc486094128179ade0ec
https://pubmed.ncbi.nlm.nih.gov/33602872
https://pubmed.ncbi.nlm.nih.gov/33602872
Autor:
Jesús Gil, Domhnall McHugh
Publikováno v:
The Journal of Cell Biology
McHugh and Gil review the role of senescence in age-related diseases and how targeting senescence may improve health span and extend life span.
Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative di
Aging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c462142d577f63907f5fcff044fab7
https://doi.org/10.1083/jcb.201708092
https://doi.org/10.1083/jcb.201708092