Výsledky vyhledávání - "Domenico Summa"

DOES RISK OF HYPERHOMOCYSTEINEMIA DEPEND ON THIOL-DISULFIDE EXCHANGE REACTIONS OF ALBUMIN AND HOMOCYSTEINE?

Autor: Lucia Coppo, Simona Scheggi, Graziella DeMontis, Raffaella Priora, Simona Frosali, Antonio Margaritis, Domenico Summa, Danila Di Giuseppe, Monica Ulivelli, Paolo Di Simplicio

Publikováno v: Antioxidantsredox signaling.

Increased plasma concentrations of total homocysteine (tHcy) (mild-moderate hyperhomocysteinemia: 15-50 µM tHcy) are considered an independent risk factor for onset/progression of various diseases, but it is not known how the increase in tHcy causes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f821dd9c187555bcc92e6a603e63c35
https://pubmed.ncbi.nlm.nih.gov/36352822

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The control of hyperhomocysteinemia through thiol exchange mechanisms by mesna

Autor: Lucia Coppo, Domenico Summa, Monica Ulivelli, Danila Di Giuseppe, Simona Frosali, Paolo Di Simplicio, Antonios Margaritis, Raffaella Priora, Sabina Bartalini

Publikováno v: Amino Acids. 46:429-439

In hyperhomocysteinemic patients, after reaction with homocysteine-albumin mixed disulfides (HSS-ALB), mesna (MSH) forms the mixed disulfide with Hcy (HSSM) which can be removed by renal clearance, thus reducing the plasma concentration of total homo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6053cc9186d921727f73f09e60e42a6
https://doi.org/10.1007/s00726-013-1636-4

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In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways

Autor: Lucia Coppo, G. P. Pessina, Domenico Summa, Paolo Di Simplicio, Danila Di Giuseppe, Antonios Margaritis, Carlo Aldinucci, Raffaella Priora, Simona Frosali, Anna Di Stefano

Publikováno v: Pharmacological Research. 64:289-297

Three different NO donors, S-nitrosoglutathione (GSNO), sodium nitroprusside (SNP) and 3-morpholino-sydnonimine hydrochloride (SIN-1) were used in order to investigate mechanisms of platelet inhibition through cGMP-dependent and -independent pathways

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ed69fbbea27d33e06d2051bef19a102
https://doi.org/10.1016/j.phrs.2011.03.014

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The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats

Autor: Lucia Coppo, Paolo Di Simplicio, Simona Frosali, Antonios Margaritis, Raffaella Priora, Jongyun Heo, Domenico Summa, Danila Di Giuseppe

Publikováno v: Toxicology and Applied Pharmacology. 242:333-343

Protein thiol modifications including cysteinylation (CSSP) and glutathionylation (GSSP) in erythrocytes of rat treated with diamide have been reported, but mechanism and origin of CSSP formation are unknown. Experiments were performed to relate CSSP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066ea817be1eaaeedd5b5f8b942c9745
https://doi.org/10.1016/j.taap.2009.11.003

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Biochemical and Biological Aspects of Protein Thiolation in Cells and Plasma

Autor: Raffaella Priora, Paolo Di Simplicio, Francesca Cherubini Di Simplicio, Anna Di Stefano, Domenico Summa, Simona Frosali, Danila Di Giuseppe

Publikováno v: Antioxidants & Redox Signaling. 7:951-963

Protein thiolation is elicited by oxidation by different mechanisms and is involved in a variety of biological processes. Thiols, protein SH (PSH) and non-protein SH groups (NPSH, namely GSH), are in competition in all biological environments in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efedde1bde9b500208850b4f7aa3d8d2
https://doi.org/10.1089/ars.2005.7.951

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Assemblies of perylene diimide derivatives with melamine into luminescent hydrogels

Autor: Claudio Zannoni, Deepak Asthana, Pradip K. Sukul, Pritam Mukhopadhyay, David Beljonne, Sudip Malik, Domenico Summa, Luca Muccioli, Alan E. Rowan

Publikováno v: Chemical Communications, 47, 11858-11860
Chemical Communications, 47, 43, pp. 11858-11860

We report unique and spontaneous formation of hydrogels of perylene derivatives with melamine. The luminescent gel network is formed by H-type aggregation of the perylene core, supramolecularly cross-linked by melamine units. As a result of controlle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d2a507744126547cdfd43c5eb1b1c4
https://pubmed.ncbi.nlm.nih.gov/21971484

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Surface supramolecular organization of a terbium (III) double-decker complex on graphite and its single molecule magnet behavior

Autor: Luca Muccioli, Umberto del Pennino, Claudio Zannoni, Jaume Veciana, Valentina De Renzi, Fabrizio Moro, Valdis Corradini, David B. Amabilino, Domenico Summa, Roberto Biagi, Mathieu Gonidec

Publikováno v: Journal of the American Chemical Society
133 (2011): 6603–6612. doi:10.1021/ja109296c
info:cnr-pdr/source/autori:Gonidec M., R. Biagi, V. Corradini, F. Moro, V. De Renzi, U. del Pennino, D. Summa, L. Muccioli, C. Zannoni, D. B. Amabilino, and J. Veciana/titolo:Surface supramolecular organization of a terbium (III) double-decker complex on graphite and its single molecule magnet behavior/doi:10.1021%2Fja109296c/rivista:Journal of the American Chemical Society (Print)/anno:2011/pagina_da:6603/pagina_a:6612/intervallo_pagine:6603–6612/volume:133

The two-dimensional self-assembly of a terbium(III) double-decker phthalocyanine on highly oriented pyrolitic graphite (HOPG) was studied by atomic force microscopy (AFM), and it was shown that it forms highly regular rectangular two-dimensional nano

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A structurally driven analysis of thiol reactivity in mammalian albumins

Autor: Simone Cirri, Simona Frosali, Andrea Bernini, Domenico Summa, Neri Niccolai, Danila Di Giuseppe, Paolo Di Simplicio, Matteo De Chiara, Antonios Margaritis, Raffaella Priora, Ottavia Spiga, Vincenzo Venditti

Understanding the structural basis of protein redox activity is still an open question. Hence, by using a structural genomics approach, different albumins have been chosen to correlate protein structural features with the corresponding reaction rates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::748b2381b0c96fb2a75ca0869196845f
http://hdl.handle.net/11365/12377

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The role of protein sulfhydryl groups and protein disulfides of the platelet surface in aggregation processes involving thiol exchange reactions

Autor: Antonios Margaritis, Danila Di Giuseppe, Raffaella Priora, Anna Di Stefano, Domenico Summa, Paolo Di Simplicio, Lucia Coppo, Simona Frosali

Publikováno v: Pharmacological research. 63(1)

Blood platelets are central to haemostasis and platelet aggregation is considered to be a direct index of platelet function. Although protein disulfides (PSSP) are structural components of most proteins, current evidence suggests that PSSP work toget

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801aae79086020aa818fe3fa86a52cce
https://pubmed.ncbi.nlm.nih.gov/20883787

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