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Publikováno v:
Proinflammatory and Antiinflammatory Peptides ISBN: 9781003064695
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7a63f33ca325e54995886372c82166d
https://doi.org/10.1201/9781003064695-11
https://doi.org/10.1201/9781003064695-11
Publikováno v:
Proinflammatory and Antiinflammatory Peptides ISBN: 9781003064695
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890e160a6f6fdd5d19c7e9d942433ea7
https://doi.org/10.1201/9781003064695-8
https://doi.org/10.1201/9781003064695-8
Publikováno v:
eLS
Two similar proteolytic cascades lead to release of bradykinin and lysbradykinin in tissues; these peptides act as autocoids, the first favouring blood clotting and endothelial protection, the second by initiating and maintaining tissue reactions to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b07f2e6e021abcc3e85b541ac7fed2
https://doi.org/10.1002/9780470015902.a0000905.pub2
https://doi.org/10.1002/9780470015902.a0000905.pub2
Autor:
Domenico Regoli, Fernand Gobeil
Publikováno v:
Biological Chemistry. 397:297-304
This paper is divided into two sections: the first contains the essential elements of the opening lecture presented by Pr. Regoli to the 2015 International Kinin Symposium in S. Paulo, Brazil on June 28th and the second is the celebration of Dr. Rego
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a2a157cf26752c4449c2c38bf6f145
https://doi.org/10.1515/hsz-2015-0240
https://doi.org/10.1515/hsz-2015-0240
Kallikrein-kinin system as the dominant mechanism to counteract hyperactive renin-angiotensin system
Autor:
Fernand Gobeil, Domenico Regoli
Publikováno v:
Canadian journal of physiology and pharmacology. 95(10)
The renin–angiotensin system (RAS) generates, maintains, and makes worse hypertension and cardiovascular diseases (CVDs) through its biologically active component angiotensin II (Ang II), that causes vasoconstriction, sodium retention, and structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfc2eb2f8efdc969f98bbbcbe70a278
https://pubmed.ncbi.nlm.nih.gov/28384411
https://pubmed.ncbi.nlm.nih.gov/28384411
Publikováno v:
Peptides. 52:82-89
We previously showed that R-954 (AcOrn[Oic 2 ,(αMe)Phe 5 , d βNal 7 ,Ile 8 ]desArg 9 -bradykinin) is a potent, selective and stable peptide antagonist of the inducible GPCR kinin B1 receptor. This compound shows potential applications for the treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea821f2c5bbdbe3e8fc69ee3713e3b22
https://doi.org/10.1016/j.peptides.2013.12.009
https://doi.org/10.1016/j.peptides.2013.12.009
Autor:
Mario Barbieri, Domenico Regoli, Michele Simonato, Brice Ongali, Andrea Buzzi, Réjean Couture, Gianluca Verlengia, Donata Rodi, Anna Binaschi, Silvia Zucchini, Alessandra Boschi
Publikováno v:
Neuroscience. 248:392-402
Bradykinin (BK) and its receptors (B1 and B2) may exert a role in the pathophysiology of certain CNS diseases, including epilepsy. In healthy tissues, B2 receptors are constitutively and widely expressed and B1 receptors are absent or expressed at ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b467a9155c478d2c163c1b7094232bd
https://doi.org/10.1016/j.neuroscience.2013.06.038
https://doi.org/10.1016/j.neuroscience.2013.06.038
Publikováno v:
Pharmacology & Therapeutics. 135:94-111
In recent years, ACE Inhibitors (ACEIs) and Angiotensin II receptor antagonists (also known as AT1 receptor antagonists (AT1-RAs), angiotensin receptor blockers (ARBs), or Sartans), have become the drugs of choice for the treatment of hypertension, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8a737dc33e595dbeb70a15f0b19980
https://doi.org/10.1016/j.pharmthera.2012.04.002
https://doi.org/10.1016/j.pharmthera.2012.04.002
Publikováno v:
Circulation Journal. 78:2154-2156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da34e7c2aa7eff2edfd9ab3feedf6518
https://doi.org/10.1253/circj.cj-14-0771
https://doi.org/10.1253/circj.cj-14-0771