Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Domenico Ravazza"'
Autor:
Miaomiao Sun, Michael Weller, Tobias Weiß, Dario Neri, Emanuele Puca, Thomas Look, Cesare Di Nitto, Eleonora Prodi, Roberto De Luca, Markus G. Manz, Ettore Gilardoni, Christian Pellegrino, Domenico Ravazza, Vlad Moisoiu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 8 (2024)
Background Anti-PD-1 antibodies have revolutionized cancer immunotherapy due to their ability to induce long-lasting complete remissions in a proportion of patients. Current research efforts are attempting to identify biomarkers and suitable combinat
Externí odkaz:
https://doaj.org/article/548220fc139c4b18925463682f754520
A novel strategy to generate immunocytokines with activity-on-demand using small molecule inhibitors
Autor:
Giulia Rotta, Ettore Gilardoni, Domenico Ravazza, Jacqueline Mock, Frauke Seehusen, Abdullah Elsayed, Emanuele Puca, Roberto De Luca, Christian Pellegrino, Thomas Look, Tobias Weiss, Markus G Manz, Cornelia Halin, Dario Neri, Sheila Dakhel Plaza
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 904-926 (2024)
Abstract Cytokine-based therapeutics have been shown to mediate objective responses in certain tumor entities but suffer from insufficient selectivity, causing limiting toxicity which prevents dose escalation to therapeutically active regimens. The a
Externí odkaz:
https://doaj.org/article/3f9295ee87c944c5ae3975d61e53a157
Autor:
Lydia Bisbal Lopez, Domenico Ravazza, Matilde Bocci, Aureliano Zana, Lucrezia Principi, Sheila Dakhel Plaza, Andrea Galbiati, Ettore Gilardoni, Jörg Scheuermann, Dario Neri, Luca Pignataro, Cesare Gennari, Samuele Cazzamalli, Alberto Dal Corso
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Immune-stimulating antibody conjugates (ISACs) equipped with imidazoquinoline (IMD) payloads can stimulate endogenous immune cells to kill cancer cells, ultimately inducing long-lasting anticancer effects. A novel ISAC was designed, featuring the IMD
Externí odkaz:
https://doaj.org/article/b9edd8a96d8444cc849c81174ca18bed
Autor:
Thomas Look, Emanuele Puca, Marcel Bühler, Daniel Kirschenbaum, Roberto De Luca, Riccardo Stucchi, Domenico Ravazza, Cesare Di Nitto, Patrick Roth, Yonatan Katzenelenbogen, Assaf Weiner, Lukas Rindlisbacher, Burkhard Becher, Ido Amit, Michael Weller, Dario Neri, Teresa Hemmerle, Tobias Weiss
Publikováno v:
Science Translational Medicine. 15
Glioblastoma is the most aggressive primary brain tumor with an unmet need for more effective therapies. Here, we investigated combination therapies based on L19TNF, an antibody-cytokine fusion protein based on tumor necrosis factor that selectively
Autor:
Giulia Rotta, Ettore Gilardoni, Domenico Ravazza, Jacqueline Mock, Samuele Cazzamalli, Roberto De Luca, Emanuele Puca, Dario Neri, Sheila Dakhel Plaza
Publikováno v:
Cancer Research. 83:5744-5744
The use of cytokine-based therapeutics has traditionally been limited by systemic toxicity, but it is now becoming evident that it may be possible to circumvent this problem in a number of ways. Tumor-targeting antibody-cytokine fusion proteins (also