Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Domenico Merante"'
Publikováno v:
Pain Research and Management, Vol 2018 (2018)
Objectives. Using patient global impression of change (PGIC) as an anchor, an approximately 30% reduction on an 11-point numeric pain intensity rating scale (PI-NRS) is considered a clinically important difference (CID) in pain. Our objective was to
Externí odkaz:
https://doaj.org/article/6b71a547bdfa4b93b0029707689c24ea
Autor:
Domenico Merante
Publikováno v:
Expert Opinion on Drug Safety
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The development of vaccines has come along far since the key contributions involving antiviral therapies and the development of vaccines against various infectious diseases made by Alexandre Mikhai...
Autor:
Domenico Merante
Aims: The main aim of this work was to identify and to share the lessons learned from the negative outcome of the mirogabalin ALDAY phase 3 clinical program in pain associated with fibromyalgia. These lessons are important to improve planning and des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7fd14db3f77c54d9fdaca0de833724
Autor:
Jeanne Mendell, Alexander Currie, James Dow, Domenico Merante, Hamim Zahir, Hitoshi Ishizuka, Mendel Jansen, Ling He, Victor Dishy
Publikováno v:
Clinical Pharmacology in Drug Development. 7:597-612
Four randomized, double-blind, placebo-controlled, 4-period drug-drug interaction studies were conducted in healthy subjects to evaluate the pharmacokinetic and pharmacodynamic (PD) interactions between mirogabalin and commonly used central nervous s
Autor:
Peter Roberts, Domenico Merante, David M. Livermore, Andrew Jones, Paul Jones, Mari Ariyasu, Richard Beale, Seema Vithlani, Jonathan D. Edgeworth, Christopher Young, Sanjay Patel, Tsutae Den Nagata, Duncan Wyncoll
Publikováno v:
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Serious infections such as endocarditis due to extremely drug-resistance gram-negative bacteria are an increasing challenge. Here, we present successful adjunctive use of cefiderocol for a patient with persistently bacteremic healthcare-associated na
Objective: To investigate the efficacy and safety of mirogabalin, an α2δ ligand, in patients with fibromyalgia (FM). Methods: In three 13-week, multicenter, double-blind, phase 3 studies (studies A, B, and C), patients with FM (n = 1293, 1270, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf1ded04e1302878f9569ffee0181c2
Publikováno v:
Pain Research & Management
Pain Research and Management, Vol 2018 (2018)
Pain Research and Management, Vol 2018 (2018)
Objectives. Using patient global impression of change (PGIC) as an anchor, an approximately 30% reduction on an 11-point numeric pain intensity rating scale (PI-NRS) is considered a clinically important difference (CID) in pain. Our objective was to
Publikováno v:
The Journal of Clinical Pharmacology. 56:203-212
A population pharmacokinetic model was developed to describe plasma concentrations of mirogabalin and lactam metabolite, obtained following a single oral dose of 5 mg mirogabalin to subjects with varying degrees of renal function.A 2-compartment mode