The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

Autor: Karla J Suchacki, Benjamin J Thomas, Yoshiko M Ikushima, Kuan-Chan Chen, Claire Fyfe, Adriana AS Tavares, Richard J Sulston, Andrea Lovdel, Holly J Woodward, Xuan Han, Domenico Mattiucci, Eleanor J Brain, Carlos J Alcaide-Corral, Hiroshi Kobayashi, Gillian A Gray, Phillip D Whitfield, Roland H Stimson, Nicholas M Morton, Alexandra M Johnstone, William P Cawthorn

Publikováno v: eLife, Vol 12 (2023)

Caloric restriction (CR) reduces the risk of age-related diseases in numerous species, including humans. CR’s metabolic effects, including decreased adiposity and improved insulin sensitivity, are important for its broader health benefits; however,

Externí odkaz: https://doaj.org/article/b9038b3cadf8461faa31dbc4889698f6

Infant leukaemia – faithful models, cell of origin and the niche

Autor: Alasdair Duguid, Domenico Mattiucci, Katrin Ottersbach

Publikováno v: Disease Models & Mechanisms, Vol 14, Iss 10 (2021)

For patients and their families, the diagnosis of infant leukaemia is devastating. This disease has not seen the improvements in outcomes experienced with other paediatric leukaemias and it is becoming ever more apparent that infant leukaemia is a di

Externí odkaz: https://doaj.org/article/45df2f906d3d4e689ca6c61280635e1f

Aging- and Senescence-associated Changes of Mesenchymal Stromal Cells in Myelodysplastic Syndromes

Autor: Domenico Mattiucci, Giulia Maurizi, Pietro Leoni, Antonella Poloni

Publikováno v: Cell Transplantation, Vol 27 (2018)

Hematopoietic stem and progenitor cells reside within the bone marrow (BM) microenvironment. By a well-balanced interplay between self-renewal and differentiation, they ensure a lifelong supply of mature blood cells. Physiologically, multiple differe

Externí odkaz: https://doaj.org/article/7b110737520b494f84cf1f4744c768fe

MiR-422a promotes adipogenesis via MeCP2 downregulation in human bone marrow mesenchymal stem cells

Autor: Angelica Giuliani, Jacopo Sabbatinelli, Stefano Amatori, Laura Graciotti, Andrea Silvestrini, Giulia Matacchione, Deborah Ramini, Emanuela Mensà, Francesco Prattichizzo, Lucia Babini, Domenico Mattiucci, Elena Marinelli Busilacchi, Maria Giulia Bacalini, Emma Espinosa, Fabrizia Lattanzio, Antonio Domenico Procopio, Fabiola Olivieri, Antonella Poloni, Mirco Fanelli, Maria Rita Rippo

Publikováno v: Cellular and Molecular Life Sciences. 80

Methyl-CpG binding protein 2 (MeCP2) is a ubiquitous transcriptional regulator. The study of this protein has been mainly focused on the central nervous system because alterations of its expression are associated with neurological disorders such as R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1720a28644859c18b5d22053ad6b3d7d
https://doi.org/10.1007/s00018-023-04719-6

The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

Autor: Karla J. Suchacki, Ben J. Thomas, Yoshiko Matsumoto Ikushima, Kuan-Chan Chen, Claire Fyfe, Adriana A.S. Tavares, Richard J. Sulston, Andrea Lovdel, Holly J. Woodward, Xuan Han, Domenico Mattiucci, Eleanor J. Brain, Carlos J. Alcaide-Corral, Hiroshi Kobayashi, Gillian A. Gray, Phillip D. Whitfield, Roland H. Stimson, Nicholas M. Morton, Alexandra M. Johnstone, William P. Cawthorn

Publikováno v: Suchacki, K, Thomas, B J, Matsumoto Ikushima, Y, Chen, K-C, Fyfe, C, Tavares, A A S, Sulston, R, Lovdel, A, Woodward, H J, Han, X, Mattiucci, D, Brain, E J, Alcaide-Corral, C J, Kobayashi, H, Gray, G A, Whitfield, P D, Stimson, R H, Morton, N M, Johnstone, A M & Cawthorn, W P 2023, ' The effects of caloric restriction on adipose tissue and metabolic health are sex-and age-dependent ', eLIFE . https://doi.org/10.7554/eLife.88080

SUMMARYCaloric restriction (CR) is a nutritional intervention that reduces the risk of age-related diseases in numerous species, including humans. CR’s metabolic effects, including decreased fat mass and improved insulin sensitivity, play an import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e42ca1d20301119d82fd01a4b86df3
https://doi.org/10.1101/2022.02.20.481222