Personalized Medicine in Mitochondrial Health and Disease: Molecular Basis of Therapeutic Approaches Based on Nutritional Supplements and Their Analogs

Autor: Vincenzo Tragni, Guido Primiano, Albina Tummolo, Lucas Cafferati Beltrame, Gianluigi La Piana, Maria Noemi Sgobba, Maria Maddalena Cavalluzzi, Giulia Paterno, Ruggiero Gorgoglione, Mariateresa Volpicella, Lorenzo Guerra, Domenico Marzulli, Serenella Servidei, Anna De Grassi, Giuseppe Petrosillo, Giovanni Lentini, Ciro Leonardo Pierri

Publikováno v: Molecules, Vol 27, Iss 11, p 3494 (2022)

Mitochondrial diseases (MDs) may result from mutations affecting nuclear or mitochondrial genes, encoding mitochondrial proteins, or non-protein-coding mitochondrial RNA. Despite the great variability of affected genes, in the most severe cases, a ne

Externí odkaz: https://doaj.org/article/00c6478da6c64681994c532e80d7955a

Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT

Autor: Alessandra, Tempio, Mauro, Niso, Luna, Laera, Lucia, Trisolini, Maria, Favia, Lucia, Ciranna, Domenico, Marzulli, Giuseppe, Petrosillo, Ciro Leonardo, Pierri, Enza, Lacivita, Marcello, Leopoldo

Publikováno v: International Journal of Molecular Sciences

Mitochondria in neurons contribute to energy supply, the regulation of synaptic transmission, Ca2+ homeostasis, neuronal excitability, and stress adaptation. In recent years, several studies have highlighted that the neurotransmitter serotonin (5-HT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef3203775143a9a0555f004d662fdced
https://pubmed.ncbi.nlm.nih.gov/33348850

Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model

Autor: Domenico De Rasmo, Daniela Valenti, Leonardo Rossi, Anna Signorile, Francesco Bellomo, Domenico Marzulli, Rosa Anna Vacca

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease 1863 (2017): 3117–3127. doi:10.1016/j.bbadis.2017.09.014
info:cnr-pdr/source/autori:Valenti, Daniela; Rossi, Leonardo; Marzulli, Domenico; Bellomo, Francesco; De Rasmo, Domenico; Signorile, Anna; Vacca, Rosa Anna/titolo:Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model/doi:10.1016%2Fj.bbadis.2017.09.014/rivista:Biochimica et biophysica acta. Molecular basis of disease/anno:2017/pagina_da:3117/pagina_a:3127/intervallo_pagine:3117–3127/volume:1863

Functional and structural damages to mitochondria have been critically associated with the pathogenesis of Down syndrome (DS), a human multifactorial disease caused by trisomy of chromosome 21 and associated with neurodevelopmental delay, intellectua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48137be0601d9e1f78cabec18fe22b91
https://doi.org/10.1016/j.bbadis.2017.09.014

Acid Stress Triggers Resistance to Acetic Acid-Induced Regulated Cell Death through Hog1 Activation Which Requires RTG2 in Yeast

Autor: Sergio Giannattasio, Mariarita Stirpe, Domenico Marzulli, Cristina Mazzoni, Nicoletta Guaragnella

Publikováno v: Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative medicine and cellular longevity (Online) 2019 (2019). doi:10.1155/2019/4651062
info:cnr-pdr/source/autori:Guaragnella, Nicoletta; Stirpe, Mariarita; Marzulli, Domenico; Mazzoni, Cristina; Giannattasio, Sergio/titolo:Acid Stress Triggers Resistance to Acetic Acid-Induced Regulated Cell Death through Hog1 Activation Which Requires RTG2 in Yeast/doi:10.1155%2F2019%2F4651062/rivista:Oxidative medicine and cellular longevity (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:2019

Acid stress causes resistance to acetic acid-induced regulated cell death (AA-RCD) in budding yeast, resulting in catalase activation. In order to explore the molecular determinants of evasion of AA-RCD triggered by acid stress adaptation, we studied

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::362d23ecf5ddd3ce8ee32fbadfda6efe
https://doaj.org/article/761745f0bad34364804cc72695b76677

Enhancement of surface electrical current on silicon via nanodiamond particles deposited by pulsed spray technique

Autor: G. Cicala, Giuseppe De Pascali, Alessandro Massaro, Domenico Marzulli, Luciano Velardi, Domenico Melisi, Giorgio S. Senesi, Vito Capozzi, Antonio Valentini, Giuseppe Perna

Publikováno v: physica status solidi (a). 212:2862-2868

The deposition of as-received nanodiamond (ND) particles on silicon substrate was performed by the pulsed spray technique, using a dispersion of 250 nm ND in 1,2-dichloroethane. A set of samples was sprayed by varying the number of pulses from 1 to 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfa92e08a5990e4e0bc1c47996b49e95
https://doi.org/10.1002/pssa.201532080