Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Domenico Maiorano"'
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102361- (2023)
Summary: Translesion DNA synthesis (TLS) is an evolutionarily conserved branch of the cellular DNA damage tolerance pathway that is often exploited by cancer cells to overcome therapy resistance. Here, we present a protocol to analyze endogenous TLS
Externí odkaz:
https://doaj.org/article/a85aacdc827f4b9390906c6b89a75cb1
Autor:
James R. A. Hutchins, Isabelle Peiffer, Serge Urbach, Jean-Louis Mergny, Philippe Marin, Domenico Maiorano, Marcel Méchali
In metazoan cells, replication of genomic DNA initiates from thousands of discrete chromosomal loci known as origins. Proteins such as the Origin Recognition Complex (ORCs) associate with origins, but this does not show clear sequence specificity for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7499f30a00d12459488a640458dd1914
https://doi.org/10.1101/2023.03.30.534946
https://doi.org/10.1101/2023.03.30.534946
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 3924 (2021)
DNA can experience “replication stress”, an important source of genome instability, induced by various external or endogenous impediments that slow down or stall DNA synthesis. While genome instability is largely documented to favor both tumor fo
Externí odkaz:
https://doaj.org/article/b067b2a5ec6a4b8db64e8e7d10ffd653
Autor:
Nesrine Benkafadar, Julien Menardo, Jérôme Bourien, Régis Nouvian, Florence François, Didier Decaudin, Domenico Maiorano, Jean‐Luc Puel, Jing Wang
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 1, Pp 7-26 (2016)
Abstract Cisplatin is a widely used chemotherapy drug, despite its significant ototoxic side effects. To date, the mechanism of cisplatin‐induced ototoxicity remains unclear, and hearing preservation during cisplatin‐based chemotherapy in patient
Externí odkaz:
https://doaj.org/article/970fbb31ba5e483990801eb6beed8d7a
Autor:
Elena Lo Furno, Isabelle Busseau, Antoine Aze, Claudio Lorenzi, Cima Saghira, Matt C Danzi, Stephan Zuchner, Domenico Maiorano
Publikováno v:
Nucleic Acids Research
In early embryogenesis of fast cleaving embryos, DNA synthesis is short and surveillance mechanisms preserving genome integrity are inefficient, implying the possible generation of mutations. We have analyzed mutagenesis in Xenopus laevis and Drosoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0a56c5aea1f78e5140d8f4f77ae942
http://europepmc.org/articles/PMC8789082
http://europepmc.org/articles/PMC8789082
Autor:
Antoine Aze, Domenico Maiorano
Publikováno v:
F1000Research, Vol 7 (2018)
DNA replication is an essential process occurring prior to cell division. Cell division coupled to proliferation ensures the growth and renewal of a large variety of specialized cell types generated during embryonic development. Changes in the DNA re
Externí odkaz:
https://doaj.org/article/31cb536141774206817ec8d33ecb0050
Publikováno v:
Methods in enzymology. 661
Maintenance and surveillance of genome integrity is crucial during the very early steps of embryonic development, since de novo mutations generated during this stage can be propagated in differentiated adult cells and may lead to predisposition to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a5dddd3b53470045e67d9c6ffa0440fb
https://pubmed.ncbi.nlm.nih.gov/34776225
https://pubmed.ncbi.nlm.nih.gov/34776225
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93663 (2014)
Pluripotency of embryonic stem cells (ESC) is tightly regulated by a network of transcription factors among which the estrogen-related receptor β (Esrrb). Esrrb contributes to the relaxation of the G1 to S-phase (G1/S) checkpoint in mouse ESCs by tr
Externí odkaz:
https://doaj.org/article/852c3df6a9894e668ab12246f5f75d1f
Publikováno v:
Methods in Enzymology ISBN: 9780323907330
Maintenance and surveillance of genome integrity is crucial during the very early steps of embryonic development, since de novo mutations generated during this stage can be propagated in differentiated adult cells and may lead to predisposition to di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c341bbb0050521ce0b75ccb0d1fa2f28
https://doi.org/10.1016/bs.mie.2021.08.016
https://doi.org/10.1016/bs.mie.2021.08.016
Publikováno v:
Genes
Genes, MDPI, 2019, 10 (5), pp.398. ⟨10.3390/genes10050398⟩
Genes, Vol 10, Iss 5, p 398 (2019)
Genes, MDPI, 2019, 10 (5), pp.398. ⟨10.3390/genes10050398⟩
Genes, Vol 10, Iss 5, p 398 (2019)
International audience; During the very early stages of embryonic development chromosome replication occurs under rather challenging conditions, including a very short cell cycle, absence of transcription, a relaxed DNA damage response and, in certai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5438f32cddd80b80d209ddaabdbad1d4
https://hal.archives-ouvertes.fr/hal-03403434
https://hal.archives-ouvertes.fr/hal-03403434