Výsledky vyhledávání - "Domenico D'Atri"

Akademický článek

Cell-specific cargo delivery using synthetic bacterial spores

Autor: Minsuk Kong, Domenico D’Atri, Maria Teresa Bilotta, Bailey Johnson, Taylor B. Updegrove, Devorah L. Gallardo, Federico Machinandiarena, I-Lin Wu, Maira Alves Constantino, Stephen M. Hewitt, Kandice Tanner, David J. Fitzgerald, Kumaran S. Ramamurthi

Publikováno v: Cell Reports, Vol 42, Iss 1, Pp 111955- (2023)

Summary: Delivery of cancer therapeutics to non-specific sites decreases treatment efficacy while increasing toxicity. In ovarian cancer, overexpression of the cell surface marker HER2, which several therapeutics target, relates to poor prognosis. We

Externí odkaz: https://doaj.org/article/98972d43a4eb4818a8c6cb579f199029

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Akademický článek

PLGA Nanoparticles Grafted with Hyaluronic Acid to Improve Site-Specificity and Drug Dose Delivery in Osteoarthritis Nanotherapy

Autor: Luana Zerrillo, Maria Rosa Gigliobianco, Domenico D’Atri, Joao Pedro Garcia, Fabio Baldazzi, Yanto Ridwan, Gastón Fuentes, Alan Chan, Laura B. Creemers, Roberta Censi, Piera Di Martino, Luis J. Cruz

Publikováno v: Nanomaterials, Vol 12, Iss 13, p 2248 (2022)

Nanoparticles (NPs) have a tremendous potential in medicinal applications, and recent studies have pushed the boundaries in nanotherapy, including in osteoarthritis treatments. The aim of this study was to develop new poly(lactide-co-glycolide) (PLGA

Externí odkaz: https://doaj.org/article/21acac82fbd7423785630b551493c74e

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Evaluation of biomimetic hyaluronic-based hydrogels with enhanced endogenous cell recruitment and cartilage matrix formation

Autor: Avner Yayon, Sibylle Grad, Nicole Kops, Andrea Lolli, M.L. Vainieri, Domenico D'Atri, G.J.V.M. van Osch, Kavitha Sivasubramaniyan, Mauro Alini, David Eglin

Publikováno v: Acta Biomaterialia, 101, 293-303. Elsevier
Acta Biomater

Biomaterials play a pivotal role in cell-free cartilage repair approaches, where cells must migrate through the scaffold, fill the defect, and then proliferate and differentiate facilitating tissue remodeling. Here we used multiple assays to test the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0394fc67e79f99f9334fcb0da1d02d57
https://pure.eur.nl/en/publications/0ede2bd1-7ed8-4154-92bb-64f7efe67e84

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Nano-ghosts: Novel biomimetic nano-vesicles for the delivery of antisense oligonucleotides

Autor: Jacopo Oieni, Gerjo J.V.M. van Osch, Nicole Kops, Marcelle Machluf, Avner Yayon, Domenico D'Atri, Andrea Lolli

Publikováno v: J control release
Journal of Controlled Release, 333, 28-40. Elsevier
Journal of Controlled Release: official journal of the Controlled Release Society, 333

Antisense oligonucleotides (ASOs) carry an enormous therapeutic potential in different research areas, however, the lack of appropriate carriers for their delivery to the target tissues is hampering their clinical translation. The present study inves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f811eff43b2f7579f48e09c584903c

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Abstract 1739: Cell-specific cargo delivery using synthetic bacterial spores

Autor: Domenico D'Atri, Minsuk Kong, Maria Teresa Bilotta, Kandice Tanner, David J. Fitzgerald, Kumaran S. Ramamurthi

Publikováno v: Cancer Research. 82:1739-1739

The overexpression of the cell surface receptor “HER-2” is a common marker for many breast and ovarian cancers. New treatments for these cancers involve the use of monoclonal antibodies directed against HER2. SSHELs are synthetic bacterial spore-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99249134b7e7825629b93a8cc53d1454
https://doi.org/10.1158/1538-7445.am2022-1739

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Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents

Autor: Fabio Colella, Jacopo Oieni, Bernardo P. Antunes, Marco Sorbona, Andrea Lolli, Serdar Capar, Luana Zerrillo, Domenico D'Atri, Yunpeng Cai, J. Garcia, Sonja Häckel, Florian P.Y. Barré, M.L. Vainieri, Laura B. Creemers

Publikováno v: Colella, F, Garcia, J P, Sorbona, M, Lolli, A, Antunes, B, D'Atri, D, Barré, F P Y, Oieni, J, Vainieri, M L, Zerrillo, L, Capar, S, Häckel, S, Cai, Y & Creemers, L B 2020, ' Drug delivery in intervertebral disc degeneration and osteoarthritis : Selecting the optimal platform for the delivery of disease-modifying agents ', Journal of Controlled Release, vol. 328, pp. 985-999 . https://doi.org/10.1016/j.jconrel.2020.08.041
Colella, Fabio; Garcia, João Pedro; Sorbona, Marco; Lolli, Andrea; Antunes, Bernardo; D'Atri, Domenico; Barré, Florian P Y; Oieni, Jacopo; Vainieri, Maria Letizia; Zerrillo, Luana; Capar, Serdar; Häckel, Sonja; Cai, Yunpeng; Creemers, Laura B (2020). Drug delivery in intervertebral disc degeneration and osteoarthritis: Selecting the optimal platform for the delivery of disease-modifying agents. Journal of controlled release, 328, pp. 985-999. Elsevier 10.1016/j.jconrel.2020.08.041
Journal of Controlled Release, 328, 985-999. ELSEVIER
Journal of Controlled Release, 328, 985-999. Elsevier
J Control Release

Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) as major cause of chronic low back pain represent the most common degenerative joint pathologies and are leading causes of pain and disability in adults. Articular cartilage (AC) and int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b2b3042e1889bd74d8bfb96e174150

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Nano-Ghosts: Biomimetic membranal vesicles, technology and characterization

Autor: Beth Schoen, Liat Yosef, Natali Malkah Dayan, Nitzan Letko Khait, Hagit Shalom-Luxenburg, Jacopo Oieni, Miguel Fliman, Domenico D'Atri, Lior Levy, Noa Cohen Anavy, Marcelle Machluf

Publikováno v: Methods (San Diego, Calif.). 177

Currently, nano-carriers for anti-cancer drug delivery are complex systems, which struggle with immunogenicity and enhanced permeability effect (EPR)-related problems that halt the clinical translation of many therapeutics. Consequently, a rapidly gr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d9c581c35aeb12deb3d42d8cb35ffd
https://pubmed.ncbi.nlm.nih.gov/31794834

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Novel PGS/PCL electrospun fiber mats with patterned topographical features for cardiac patch applications

Autor: Marwa Tallawi, Judith A. Roether, Ranjana Rai, Domenico D'Atri, Dirk W. Schubert, Dirk Dippold, Elisabetta Rosellini, Aldo R. Boccaccini, Felix B. Engel

Publikováno v: Materials Science and Engineering: C. 69:569-576

Nano- and micro-scale topographical features play a critical role in the induction and maintenance of various cellular properties and functions, including morphology, adhesion, gene regulation, and cell-to-cell communication. In addition, recent stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf78be1e90686235adb9593ebdd54b7f
https://doi.org/10.1016/j.msec.2016.06.083

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Pretreating Mesenchymal Stem Cells with Cancer Conditioned‐Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells

Autor: Alona Shagan, Shani Hamias, Jacopo Oieni, Marcelle Machluf, Domenico D'Atri, Galoz Kaneti, Liat Amram, Noa Cohen Anavy, Hagit Shalom-Luxenburg, Tomer Bronshtein, Yael Lupu-Haber, Limor Kaneti

Publikováno v: Advanced Healthcare Materials. 8:1801589

Nanoghosts (NGs) are nanovesicles reconstructed from the cytoplasmic membranes of mesenchymal stem cells (MSCs). By retaining MSC membranes, the NGs retain the ability of these cells to home in on multiple tumors, laying the foundations, thereby, for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a7fe488752052e4a19b60a5da6643e
https://doi.org/10.1002/adhm.201801589

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