Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Domenico D'Arca"'
Autor:
Gaetano Marverti, Maria Gaetana Moschella, Alice Belardo, Michele Lamesta, Giada Mercanile, Lorenzo Tagliazucchi, Daniele Aiello, Alberto Venturelli, Davide Illuminati, Remo Guerrini, Lorena Losi, Glauco Ponterini, Maria Paola Costi, Domenico D’Arca
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
IntroductionThymidylate synthase (TS) plays a crucial role in cellular growth, proliferation, DNA synthesis, and repair, thus gaining attention for targeted therapies in cancer. TS overexpression and the altered pharmacokinetics of anti-TS drugs are
Externí odkaz:
https://doaj.org/article/047183af72c145208a402c02d10e8d5a
Autor:
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Publikováno v:
eLife, Vol 11 (2022)
Drugs that target human thymidylate synthase (hTS), a dimeric enzyme, are widely used in anticancer therapy. However, treatment with classical substrate-site-directed TS inhibitors induces over-expression of this protein and development of drug resis
Externí odkaz:
https://doaj.org/article/6b5ed787a8314e518ea035b5e470ee7c
Autor:
Lorena Losi, Angela Lauriola, Erica Tazzioli, Gaia Gozzi, Letizia Scurani, Domenico D’Arca, Jean Benhattar
Publikováno v:
Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background All-trans retinoic acid (ATRA) is currently being used to treat hematological malignancies, given the ability to inhibit cell proliferation. This effect seems to be related to epigenetic changes of the TERT (Telomerase Reverse Tra
Externí odkaz:
https://doaj.org/article/8f66113f4e574bcb89d0e32fbb21bc0a
Autor:
Angela Lauriola, Pierpaola Davalli, Gaetano Marverti, Andrea Caporali, Sabine Mai, Domenico D’Arca
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1602 (2022)
Recently, we highlighted a novel role for the protein Trichoplein/TCHP/Mitostatin (TpMs), both as mitotic checkpoint regulator and guardian of chromosomal stability. TpMs-depleted cells show numerical and structural chromosome alterations that lead t
Externí odkaz:
https://doaj.org/article/813303ec32d74059815f5300bd51c498
Autor:
Angela Lauriola, Elisa Uliassi, Matteo Santucci, Maria Laura Bolognesi, Marco Mor, Laura Scalvini, Gian Marco Elisi, Gaia Gozzi, Lorenzo Tagliazucchi, Gaetano Marverti, Stefania Ferrari, Lorena Losi, Domenico D’Arca, Maria Paola Costi
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 391 (2022)
The transcriptional regulators YAP (Yes-associated protein) and TAZ (transcriptional co-activator with PDZ-binding motif) are the major downstream effectors in the Hippo pathway and are involved in cancer progression through modulation of the activit
Externí odkaz:
https://doaj.org/article/6b37af2ad3704c51b856208309d6c8c9
Autor:
Leda Severi, Lorena Losi, Sergio Fonda, Laura Taddia, Gaia Gozzi, Gaetano Marverti, Fulvio Magni, Clizia Chinello, Martina Stella, Jalid Sheouli, Elena I. Braicu, Filippo Genovese, Angela Lauriola, Chiara Marraccini, Alessandra Gualandi, Domenico D'Arca, Stefania Ferrari, Maria P. Costi
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Proteomics and bioinformatics are a useful combined technology for the characterization of protein expression level and modulation associated with the response to a drug and with its mechanism of action. The folate pathway represents an important tar
Externí odkaz:
https://doaj.org/article/c50cb9ee62ed45b9a7472c16b53fe9b5
Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth
Autor:
Salvatore Pacifico, Matteo Santucci, Rosaria Luciani, Puneet Saxena, Pasquale Linciano, Glauco Ponterini, Angela Lauriola, Domenico D’Arca, Gaetano Marverti, Remo Guerrini, Maria Paola Costi
Publikováno v:
Molecules, Vol 24, Iss 19, p 3493 (2019)
Thymidylate synthase (TS) is a prominent drug target for different cancer types. However, the prolonged use of its classical inhibitors, substrate analogs that bind at the active site, leads to TS overexpression and drug resistance in the clinic. In
Externí odkaz:
https://doaj.org/article/61da817c7a194f56a082b000a4c8c452
Autor:
Matteo Fassan, Domenico D'Arca, Juraj Letko, Andrea Vecchione, Marina P Gardiman, Peter McCue, Bernadette Wildemore, Massimo Rugge, Dolores Shupp-Byrne, Leonard G Gomella, Andrea Morrione, Renato V Iozzo, Raffaele Baffa
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19771 (2011)
MITOSTATIN, a novel putative tumor suppressor gene induced by decorin overexpression, is expressed in most normal human tissues but is markedly down-regulated in advanced stages of mammary and bladder carcinomas. Mitostatin negatively affects cell gr
Externí odkaz:
https://doaj.org/article/d9f46bfa256f446d8ff4893282fd87db
Autor:
Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdeb9c0a07f471fb49b11123dde41c43
https://doi.org/10.7554/elife.73862.sa2
https://doi.org/10.7554/elife.73862.sa2
Autor:
Domenico D’Arca, Leda Severi, Stefania Ferrari, Luca Dozza, Gaetano Marverti, Fulvio Magni, Clizia Chinello, Lisa Pagani, Lorenzo Tagliazucchi, Marco Villani, Gianluca d’Addese, Isabella Piga, Vincenza Conteduca, Lorena Rossi, Giorgia Gurioli, Ugo De Giorgi, Lorena Losi, Maria Paola Costi
Publikováno v:
Cancers; Volume 15; Issue 2; Pages: 412
Ovarian cancer is a highly lethal gynecological malignancy. Drug resistance rapidly occurs, and different therapeutic approaches are needed. So far, no biomarkers have been discovered to predict early response to therapies in the case of multi-treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b9d87c9589554dc448a86dc863409e4
https://doi.org/10.3390/cancers15020412
https://doi.org/10.3390/cancers15020412