Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Domenico Albino"'
Autor:
Alessia Cacciatore, Dheeraj Shinde, Carola Musumeci, Giada Sandrini, Luca Guarrera, Domenico Albino, Gianluca Civenni, Elisa Storelli, Simone Mosole, Elisa Federici, Alessio Fusina, Marta Iozzo, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Marco Bolis, Carlo V. Catapano, Giuseppina M. Carbone
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Castration-resistant prostate cancer (CRPC) is a frequently occurring disease with adverse clinical outcomes and limited therapeutic options. Here, we identify methionine adenosyltransferase 2a (MAT2A) as a critical driver of the androgen-in
Externí odkaz:
https://doaj.org/article/724f72ec506f4c06aa1670dd1c8ab69a
Autor:
Marita Zoma, Laura Curti, Dheeraj Shinde, Domenico Albino, Abhishek Mitra, Jacopo Sgrignani, Sarah N. Mapelli, Giada Sandrini, Gianluca Civenni, Jessica Merulla, Giovanna Chiorino, Paolo Kunderfranco, Alessia Cacciatore, Aleksandra Kokanovic, Andrea Rinaldi, Andrea Cavalli, Carlo V. Catapano, Giuseppina M. Carbone
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Although the TMPRSS2-ERG gene fusion is the most common alteration in human prostate cancer, its involvement in disease progression remains unclear. Here, the authors demonstrate that ERG is methylated by Enhancer of zest homolog 2 leading to enhance
Externí odkaz:
https://doaj.org/article/e634d5688e6b4dc7aff08bbd1aa3f1c9
Autor:
Tiziano Bernasocchi, Geniver El Tekle, Marco Bolis, Azzurra Mutti, Arianna Vallerga, Laura P. Brandt, Filippo Spriano, Tanya Svinkina, Marita Zoma, Valentina Ceserani, Anna Rinaldi, Hana Janouskova, Daniela Bossi, Manuela Cavalli, Simone Mosole, Roger Geiger, Ze Dong, Cai-Guang Yang, Domenico Albino, Andrea Rinaldi, Peter Schraml, Simon Linder, Giuseppina M. Carbone, Andrea Alimonti, Francesco Bertoni, Holger Moch, Steven A. Carr, Wilbert Zwart, Marianna Kruithof-de Julio, Mark A. Rubin, Namrata D. Udeshi, Jean-Philippe P. Theurillat
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Gene fusions involving the ERG transcription factor and point mutations in the ubiquitin ligase adaptor SPOP are two truncal mutations that are mutually exclusively present in prostate cancer. Here, the authors show that mutations in SPOP render pros
Externí odkaz:
https://doaj.org/article/f2c4c2cbe140413794b564af2e6c8775
Autor:
Domenico Albino, Martina Falcione, Valeria Uboldi, Dada Oluwaseyi Temilola, Giada Sandrini, Jessica Merulla, Gianluca Civenni, Aleksandra Kokanovic, Alessandra Stürchler, Dheeraj Shinde, Mariangela Garofalo, Ricardo Pereira Mestre, Vera Constâncio, Martha Wium, Jacopo Burrello, Nicolò Baranzini, Annalisa Grimaldi, Jean-Philippe Theurillat, Daniela Bossi, Lucio Barile, Rui M. Henrique, Carmen Jeronimo, Luiz Fernando Zerbini, Carlo V. Catapano, Giuseppina M. Carbone
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Following on reports that miR-424 expression promotes oncogenesis, Domenico Albino et al. find that extracellular vesicles (EVs) in the plasma of prostate cancer patients secrete miR-424. Using cell-based and animal models, they demonstrate that EV-m
Externí odkaz:
https://doaj.org/article/28200d6da1754aecbc8751a32e04f961
Autor:
Giuseppina Pisignano, Sara Napoli, Marco Magistri, Sarah N. Mapelli, Chiara Pastori, Stefano Di Marco, Gianluca Civenni, Domenico Albino, Claudia Enriquez, Sara Allegrini, Abhishek Mitra, Gioacchino D’Ambrosio, Maurizia Mello-Grand, Giovanna Chiorino, Ramon Garcia-Escudero, Gabriele Varani, Giuseppina M. Carbone, Carlo V. Catapano
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Promoter-proximal transcripts have been proposed to act ascis-acting elements regulating transcription. Here, the authors provide evidence that a promoter-proximal RNA, in combination with other epigenetic regulators, controls transcription of E-cadh
Externí odkaz:
https://doaj.org/article/30abb6e59ccc403ba1c9e976c95d4eef
Autor:
Gianluca Civenni, Domenico Albino, Dheeraj Shinde, Ramiro Vázquez, Jessica Merulla, Aleksandra Kokanovic, Sarah N. Mapelli, Giuseppina M. Carbone, Carlo V. Catapano
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Prostate cancer is the most common malignancy in men and the second cause of cancer-related deaths in western countries. Despite the progress in the treatment of localized prostate cancer, there is still lack of effective therapies for the advanced f
Externí odkaz:
https://doaj.org/article/7def8a046cad40a3aab47f3e7b7232d6
Publikováno v:
Current Protocols. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4885daffb61a5308ac13699a54e146b1
https://doi.org/10.1002/cpz1.742
https://doi.org/10.1002/cpz1.742
Autor:
Carlo V. Catapano, Giuseppina M. Carbone, Francisco Morís, Luz Elena Nuñez, Domenico Albino, Cristina García Inclán, Cecilia Dallavalle, Paula Costales, Nicole Longoni, Gianluca Civenni
Supplementary figure 4. Caspase 3 assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369679c7510b56b01adf1ff8268976f9
https://doi.org/10.1158/1535-7163.22508764
https://doi.org/10.1158/1535-7163.22508764
Autor:
Carlo V. Catapano, Giuseppina M. Carbone, Francisco Morís, Luz Elena Nuñez, Domenico Albino, Cristina García Inclán, Cecilia Dallavalle, Paula Costales, Nicole Longoni, Gianluca Civenni
Supplementary figure 2. Cell viability evaluated by SRB assay after treatment with EC-70124 in DU145
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e80d2da6268bf98aae73c69cb6d0d8
https://doi.org/10.1158/1535-7163.22508770.v1
https://doi.org/10.1158/1535-7163.22508770.v1
Autor:
Carlo V. Catapano, Giuseppina M. Carbone, Francisco Morís, Luz Elena Nuñez, Domenico Albino, Cristina García Inclán, Cecilia Dallavalle, Paula Costales, Nicole Longoni, Gianluca Civenni
Supplementary figure 3. Cell viability evaluated by SRB assay after treatment with EC-70124 in PC3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6224459d56f920d93d34ef19e8a12bb
https://doi.org/10.1158/1535-7163.22508767
https://doi.org/10.1158/1535-7163.22508767