Výsledky vyhledávání - "Domenick Zammit"

Akademický článek

Autor: Domenick Zammit, Russell E. Ettinger, Paymon Sanati-Mehrizy, Srinivas M. Susarla

Publikováno v: Medicina, Vol 59, Iss 12, p 2100 (2023)

Orthognathic surgery has evolved significantly over the past century. Osteotomies of the midface and mandible are contemporaneously used to perform independent or coordinated movements to address functional and aesthetic problems. Specific advances i

Externí odkaz: https://doaj.org/article/8a765435a9f444088be29d866ac95c16

Zobrazit plný text záznamu

Supplementary Figure 3 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

Autor: Nahum Sonenberg, Ivan Topisirovic, Yi Liu, Valentina Gandin, Lucie-Anne Voyer, Peter Metrakos, Victoria Marcus, Domenick Zammit, Mamatha Bhat, Nadeem Siddiqui, Akiko Yanagiya, Bruno D. Fonseca, Masahiro Morita, Tommy Alain

PDF file - 2.9MB, Figure S3 contains data that show that cells with elevated eIF4E expression exhibit resistance to asTORi. These data complement the main figures of the manuscript

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741df993bd8ce1f83833e7b51c6479ad
https://doi.org/10.1158/0008-5472.22395990

Zobrazit plný text záznamu

Supplementary Figure 2 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

PDF file - 2.7MB, Figure S2 contains data that show that cells with reduced levels of 4E-BP1/2 have increased resistance to the anti-neoplastic effects of PP242.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089ebd7523754d0e243b489c1e8fb7ec
https://doi.org/10.1158/0008-5472.22395993

Zobrazit plný text záznamu

Supplementary Figure Legends 1-4 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

PDF file - 101K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c1714beb66eda4194a1348d62f0bf3
https://doi.org/10.1158/0008-5472.22395981

Zobrazit plný text záznamu

Supplementary Figure 4 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

PDF file - 2.3MB, Figure S4 contains data that show that the eIF4E/4E-BP ratio influences the antiproliferative efficacy of asTORi.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df800fd6ec4530a5d07d5f4583a6420
https://doi.org/10.1158/0008-5472.22395987.v1

Zobrazit plný text záznamu

Supplementary Figure 1 from eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

PDF file - 2.1MB, Figure S1 contains data that show that cells acquire resistance to the anti-proliferative effects of PP242 by downregulating 4E-BP1 and 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90938a63dda32d0d16e43d30401ef562
https://doi.org/10.1158/0008-5472.22395996.v1

Zobrazit plný text záznamu

eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

Autor: Bruno D. Fonseca, Mamatha Bhat, Nahum Sonenberg, Victoria Marcus, Masahiro Morita, Lucie Anne Voyer, Peter Metrakos, Tommy Alain, Yi Liu, Nadeem Siddiqui, Valentina Gandin, Domenick Zammit, Ivan Topisirovic, Akiko Yanagiya

Publikováno v: Cancer Research. 72:6468-6476

Active-site mTOR inhibitors (asTORi) hold great promise for targeting dysregulated mTOR signaling in cancer. Because of the multifaceted nature of mTORC1 signaling, identification of reliable biomarkers for the sensitivity of tumors to asTORi is impe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fae6aa1bf3d9f85961305ca49c283c
https://doi.org/10.1158/0008-5472.can-12-2395

Zobrazit plný text záznamu

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells

Autor: Gregory J. Gores, Yunhao Zhao, Michael Pollak, Chadi Zakaria, Masahiro Morita, Mamatha Bhat, Tommy Alain, Nahum Sonenberg, Nataliya Razumilava, Maritza Jaramillo, Domenick Zammit, Tyson E. Graber, Akiko Yanagiya, Peter Metrakos, Steve F. Bronk

Publikováno v: Oncotarget
Oncotarget, Impact journals, 2016, ⟨10.18632/oncotarget.10671⟩

International audience; Metformin inhibits the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, which is frequently upregulated in hepatocellular carcinoma (HCC). Metformin has also been shown to induce apoptosis in this cancer. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2756a94873df596b2fc658dd8f4dd2
https://hal-pasteur.archives-ouvertes.fr/pasteur-01350841/file/10671-162277-2-PB.pdf

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání