Dopamine neuron dysfunction and loss in the PrknR275W mouse model of juvenile parkinsonism.

Autor: Regoni M; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy., Zanetti L; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy., Sevegnani M; Dulbecco Telethon Institute, Laboratory of Biology of Synapse, Center for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Domenicale C; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy., Magnabosco S; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy., Patel JC; Department of Neurosurgery, New York University Grossman School of Medicine, New York, NY 10016, USA., Fernandes MK; Department of Neurosurgery, New York University Grossman School of Medicine, New York, NY 10016, USA., Feeley RM; Department of Neurosurgery, New York University Grossman School of Medicine, New York, NY 10016, USA., Monzani E; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Mini C; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy.; Department of Statistics, Computer Science, Applications (DiSIA), University of Florence, 50134 Florence, Italy., Comai S; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35122 Padova, Italy.; Department of Biomedical Sciences, University of Padova, 35122 Padova, Italy., Cherchi L; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., De Gregorio D; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy., Soliman I; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Ruto F; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Croci L; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy., Consalez G; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy., Rodighiero S; Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, Milan 20139, Italy., Ciammola A; IRCCS Istituto Auxologico Italiano, Department of Neurology and Laboratory of Neuroscience, 20149 Milan, Italy., Valtorta F; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy., Morari M; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35122 Padova, Italy., Piccoli G; Dulbecco Telethon Institute, Laboratory of Biology of Synapse, Center for Integrative Biology (CIBIO), University of Trento, 38123 Trento, Italy., Rice ME; Department of Neurosurgery, New York University Grossman School of Medicine, New York, NY 10016, USA., Sassone J; Division of Neuroscience, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01.

Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice.

Autor: Domenicale C; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy., Mercatelli D; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.; Technopole of Ferrara, LTTA Laboratory for Advanced Therapies, 44121 Ferrara, Italy., Albanese F; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy., Novello S; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.; Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland., Vincenzi F; Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy., Varani K; Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy., Morari M; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy.

Publikováno v: Biomedicines [Biomedicines] 2022 Apr 12; Vol. 10 (4). Date of Electronic Publication: 2022 Apr 12.

In vivo susceptibility to energy failure parkinsonism and LRRK2 kinase activity.

Autor: Novello S; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. Electronic address: salvatore.novello@epfl.ch., Mercatelli D; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy; Technopole of Ferrara, LTTA Laboratory for Advanced Therapies, 44121 Ferrara, Italy. Electronic address: daniela.mercatelli@unife.it., Albanese F; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. Electronic address: federica.albanese@unife.it., Domenicale C; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. Electronic address: chiara.domenicale@unife.it., Brugnoli A; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. Electronic address: alberto.brugnoli@unife.it., D'Aversa E; Department of Life Science and Biotechnology, University of Ferrara, 44121 Ferrara, Italy. Electronic address: elisabetta.daversa@unife.it., Vantaggiato S; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy., Dovero S; Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France. Electronic address: sandra.dovero@u-bordeaux.fr., Murtaj V; Nuclear Medicine Department, San Raffaele Scientific Institute, Milan, Italy; PhD Program in Neuroscience, School of Medicine and Surgery, University of Milano Bicocca, Monza, Italy; Medicine and Surgery Department, University of Milano Bicocca, Monza, Italy. Electronic address: murtaj.valentina@hsr.it., Presotto L; Nuclear Medicine Department, San Raffaele Scientific Institute, Milan, Italy. Electronic address: presotto.luca@hsr.it., Borgatti M; Department of Life Science and Biotechnology, University of Ferrara, 44121 Ferrara, Italy. Electronic address: monica.borgatti@unife.it., Shimshek DR; Department of Neuroscience, Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002 Basel, Switzerland. Electronic address: derya.shimshek@novartis.com., Bezard E; Université de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France. Electronic address: erwan.bezard@u-bordeaux.fr., Moresco RM; Nuclear Medicine Department, San Raffaele Scientific Institute, Milan, Italy; Medicine and Surgery Department, University of Milano Bicocca, Monza, Italy; Institute of Molecular Bioimaging and Physiology (IBFM), CNR, Segrate, Italy. Electronic address: moresco.rosamaria@hsr.it., Belloli S; Nuclear Medicine Department, San Raffaele Scientific Institute, Milan, Italy; Medicine and Surgery Department, University of Milano Bicocca, Monza, Italy; Institute of Molecular Bioimaging and Physiology (IBFM), CNR, Segrate, Italy. Electronic address: belloli.sara@hsr.it., Morari M; Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. Electronic address: m.morari@unife.it.

Publikováno v: Neurobiology of disease [Neurobiol Dis] 2022 Jan; Vol. 162, pp. 105579. Date of Electronic Publication: 2021 Dec 03.

Methamphetamine Increases Tubulo-Vesicular Areas While Dissipating Proteins from Vesicles Involved in Cell Clearance.

Autor: Lazzeri, Gloria¹ (AUTHOR) gloria.lazzeri@unipi.it, Lenzi, Paola¹ (AUTHOR) paola.lenzi@unipi.it, Busceti, Carla L.² (AUTHOR) carla.busceti@neuromed.it, Puglisi-Allegra, Stefano² (AUTHOR) stefano.puglisiallegra@neuromed.it, Ferrucci, Michela¹ (AUTHOR) michela.ferrucci@unipi.it, Fornai, Francesco^1,2 (AUTHOR) michela.ferrucci@unipi.it

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9601. 25p.

LRRK2 Kinase Inhibition Attenuates Neuroinflammation and Cytotoxicity in Animal Models of Alzheimer's and Parkinson's Disease-Related Neuroinflammation.

Autor: Mutti, Veronica¹ (AUTHOR) vmutti@fatebenefratelli.eu, Carini, Giulia^1,2 (AUTHOR), Filippini, Alice^1,2 (AUTHOR), Castrezzati, Stefania³ (AUTHOR), Giugno, Lorena³ (AUTHOR), Gennarelli, Massimo^1,2 (AUTHOR), Russo, Isabella^1,2 (AUTHOR) isabella.russo@unibs.it

Publikováno v: Cells (2073-4409). Jul2023, Vol. 12 Issue 13, p1799. 16p.