Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Domenica Musumeci"'
Autor:
Silvia Nuzzo, Margherita Iaboni, Maria Luigia Ibba, Anna Rienzo, Domenica Musumeci, Monica Franzese, Giuseppina Roscigno, Alessandra Affinito, Gianluca Petrillo, Cristina Quintavalle, Giuseppe Ciccone, Carla Lucia Esposito, Silvia Catuogno
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Hypoxia plays a crucial role in tumorigenesis and drug resistance, and it is recognised as a major factor affecting patient clinical outcome. Therefore, the detection of hypoxic areas within the tumour micro-environment represents a useful way to mon
Externí odkaz:
https://doaj.org/article/574150afabb14c51833f312d2ef186ac
Publikováno v:
Molecules, Vol 28, Iss 15, p 5775 (2023)
Ru-based chemotherapy is emerging as an effective alternative to the well-established Pt-based one, typically associated with high toxicity. In this context, our recent efforts were devoted to the preparation of nucleolipid-based Ru(III) complexes ab
Externí odkaz:
https://doaj.org/article/8205f699b01c4250befdb78eb3540f3a
Autor:
Andrea Criscuolo, Ettore Napolitano, Claudia Riccardi, Domenica Musumeci, Chiara Platella, Daniela Montesarchio
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2361 (2022)
G-quadruplexes turned out to be important targets for the development of novel targeted anticancer/antiviral therapies. More than 3000 G-quadruplex small-molecule ligands have been described, with most of them exerting anticancer/antiviral activity b
Externí odkaz:
https://doaj.org/article/5523c6c8e44649f48aa9e1583f96a56f
Autor:
Francesca Greco, Domenica Musumeci, Nicola Borbone, Andrea Patrizia Falanga, Stefano D’Errico, Monica Terracciano, Ilaria Piccialli, Giovanni Nicola Roviello, Giorgia Oliviero
Publikováno v:
Molecules, Vol 27, Iss 9, p 2997 (2022)
Trans-polydatin (tPD), the 3-β-D-glucoside of the well-known nutraceutical trans-resveratrol, is a natural polyphenol with documented anti-cancer, anti-inflammatory, cardioprotective, and immunoregulatory effects. Considering the anticancer activity
Externí odkaz:
https://doaj.org/article/3ed61f36c89d4ac699649e69780a6f51
Autor:
Fulvio Perrella, Federico Coppola, Alessio Petrone, Chiara Platella, Daniela Montesarchio, Annarita Stringaro, Giampietro Ravagnan, Maria Pia Fuggetta, Nadia Rega, Domenica Musumeci
Publikováno v:
Biomolecules, Vol 11, Iss 7, p 1048 (2021)
In the search for new therapeutic strategies to contrast SARS-CoV-2, we here studied the interaction of polydatin (PD) and resveratrol (RESV)—two natural stilbene polyphenols with manifold, well known biological activities—with Spike, the viral p
Externí odkaz:
https://doaj.org/article/41f0f64d6ec2442383c2846c131d74af
Autor:
Pasqualina Liana Scognamiglio, Chiara Platella, Ettore Napolitano, Domenica Musumeci, Giovanni Nicola Roviello
Publikováno v:
Molecules, Vol 26, Iss 12, p 3558 (2021)
Peptides and their synthetic analogs are a class of molecules with enormous relevance as therapeutics for their ability to interact with biomacromolecules like nucleic acids and proteins, potentially interfering with biological pathways often involve
Externí odkaz:
https://doaj.org/article/777b280f684b48549278643b0687b35b
Publikováno v:
Molecules, Vol 25, Iss 22, p 5227 (2020)
Multivalent interactions frequently occur in biological systems and typically provide higher binding affinity and selectivity in target recognition than when only monovalent interactions are operative. Thus, taking inspiration by nature, bivalent or
Externí odkaz:
https://doaj.org/article/6f0361881f0d4a9289f4fda49cf1434b
Autor:
Claudia Riccardi, Domenica Capasso, Angela Coppola, Chiara Platella, Daniela Montesarchio, Sonia Di Gaetano, Giovanni N. Roviello, Domenica Musumeci
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 284 (2020)
We here report our studies on the reaction with the platinum(II) ion of a nucleoamino acid constituted by the l-2,3-diaminopropanoic acid linked to the thymine nucleobase through a methylenecarbonyl linker. The obtained new platinum complexes, charac
Externí odkaz:
https://doaj.org/article/35262f741e8946dabf455aec2ad57c49
Publikováno v:
Molecules, Vol 20, Iss 9, Pp 17511-17532 (2015)
Though a variety of different non-canonical nucleic acids conformations have been recognized, G-quadruplex structures are probably the structural motifs most commonly found within known oligonucleotide-based aptamers. This could be ascribed to severa
Externí odkaz:
https://doaj.org/article/d859e357bdd94b4daab5214add7bcf8e
Autor:
Giovanni N. Roviello, Domenica Musumeci, Valentina Roviello, Marina Pirtskhalava, Alexander Egoyan, Merab Mirtskhulava
Publikováno v:
Beilstein Journal of Nanotechnology, Vol 6, Iss 1, Pp 1338-1347 (2015)
The employment of molecular tools with nucleic acid binding ability to specifically control crucial cellular functions represents an important scientific area at the border between biochemistry and pharmaceutical chemistry. In this review we describe
Externí odkaz:
https://doaj.org/article/3830c91dc1b646fcaeb308fb46b309fc