Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Domenica Saul"'
Autor:
Lukas Häselbarth, Sara Gamali, Domenica Saul, Manuela Krumbholz, Romy Böttcher-Loschinski, Martin Böttcher, Deyu Zou, Markus Metzler, Axel Karow, Dimitrios Mougiakakos
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Chronic myeloid leukemia (CML) is effectively treated with tyrosine kinase inhibitors (TKIs), targeting the BCR::ABL1 oncoprotein. Still, resistance to therapy, relapse after treatment discontinuation, and side effects remain significant iss
Externí odkaz:
https://doaj.org/article/21d4649d4b6548ffaf9e27d12209e88a
Autor:
Snigdha Majumder, Isabelle Jugovic, Domenica Saul, Luisa Bell, Nadine Hundhausen, Rishav Seal, Andreas Beilhack, Andreas Rosenwald, Dimitrios Mougiakakos, Friederike Berberich-Siebelt
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Gene editing of primary T cells is a difficult task. However, it is important for research and especially for clinical T-cell transfers. CRISPR/Cas9 is the most powerful gene-editing technique. It has to be applied to cells by either retroviral trans
Externí odkaz:
https://doaj.org/article/ba4a939100cb4bc385aea5698087a5bc
Autor:
Regina Jitschin, Domenica Saul, Martina Braun, Sehmus Tohumeken, Simon Völkl, Roman Kischel, Michael Lutteropp, Cedric Dos Santos, Andreas Mackensen, Dimitrios Mougiakakos
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-6 (2018)
Abstract Acute myeloid leukemia (AML) is the most common acute leukemia amongst adults with a 5-year overall survival lower than 30%. Emerging evidence suggest that immune alterations favor leukemogenesis and/or AML relapse thereby negatively impacti
Externí odkaz:
https://doaj.org/article/1c9a3d273f454e1ba02104b527ded32d
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
(A) Induction of an MDSC phenotype by AML-derived soluble factors, (B) Induction of IDO-activity by AML-EVs, (C) ZetaView-based analysis of AML-EVs, and (D) Impact of chemotherapy on EV release by AML cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e4ad28cb125bc12ed2b43d6a9f02de
https://doi.org/10.1158/0008-5472.22426534
https://doi.org/10.1158/0008-5472.22426534
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
(A) Impact of anti-TLR4 antibodies on MDSC induction, (B) Impact of anti-TLR2 antibodies on pCREB activation, (C) Impact of PrK pre-treatment of AML-EV uptake, (D) Impact of chemotherapy on protein palmitoylation in AML-cells, and (E) Impact of 2-BP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4ad9dca2fc85631fed252e331b3faa
https://doi.org/10.1158/0008-5472.22426522
https://doi.org/10.1158/0008-5472.22426522
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
Changes of mitochondrial (A) membrane potential, (B) ROS production, and (C) mass in monocytes upon AML-EV uptake.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c357f0b4655e9015406cd23c3b4ee9d
https://doi.org/10.1158/0008-5472.22426525.v1
https://doi.org/10.1158/0008-5472.22426525.v1
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
(A) CD33 expression on AML-EVs, (B) Cytokine-content of AML-EVs, (C) Localization analysis of AML-EVs in monocytes, (D) Control experiment regarding EV-independent uptake of PKH26.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fae5addddb32e4133856cb4b761843
https://doi.org/10.1158/0008-5472.22426531.v1
https://doi.org/10.1158/0008-5472.22426531.v1
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
(A) Induction of MDSCs by AML-EVs released by chemotherapy-pretreated AML celllines, (B) Phagocytotic activity of monocytes upon AML-EV uptake, (C) Induction of MDSCs by AML-EVs isolated by gradient ultracentrifugation, (D) Induction of pCREB by AML-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee028fa40086f9afac2923faf4ee47b
https://doi.org/10.1158/0008-5472.22426528.v1
https://doi.org/10.1158/0008-5472.22426528.v1
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
Acute myeloid leukemia (AML) represents the most common acute leukemia among adults. Despite recent progress in diagnosis and treatment, long-term outcome remains unsatisfactory. The success of allogeneic stem cell transplantation underscores the imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ee54c64953f897eeed67cf9c03c1b2
https://doi.org/10.1158/0008-5472.c.6512365
https://doi.org/10.1158/0008-5472.c.6512365
Autor:
Dimitrios Mougiakakos, Regina Jitschin, Andreas Mackensen, Heiko Bruns, Andreas S. Baur, Simon Völkl, Domenica Saul, Martina Braun, Konstantinos Panagiotidis, Romy Loschinski, Andrej Stoll, Martin Böttcher, Rebecca Baur, Sehmus Tohumeken
Information regarding patient characteristics, antibodies, and primers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d632ce11a7d5c3fd37744fff07f1d468
https://doi.org/10.1158/0008-5472.22426519.v1
https://doi.org/10.1158/0008-5472.22426519.v1