Biotechnological production optimization of argyrins – a potent immunomodulatory natural product class

Autor: Domen Pogorevc, Rolf Müller

Publikováno v: Microbial Biotechnology, Vol 15, Iss 1, Pp 353-369 (2022)

Summary Argyrins represent a family of cyclic octapeptides exhibiting promising immunomodulatory activity via inhibiting mitochondrial protein synthesis, which leads to reduced IL‐17 production by the T‐helper 17 cells. Argyrins are formed by a n

Externí odkaz: https://doaj.org/article/f17c7aa91f5f496b9e006b81f85a1c33

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections.

Autor: Andrea Schiefer, Marc P Hübner, Anna Krome, Christine Lämmer, Alexandra Ehrens, Tilman Aden, Marianne Koschel, Helene Neufeld, Lillibeth Chaverra-Muñoz, Rolf Jansen, Stefan Kehraus, Gabriele M König, Domen Pogorevc, Rolf Müller, Marc Stadler, Stephan Hüttel, Thomas Hesterkamp, Karl Wagner, Kenneth Pfarr, Achim Hoerauf

Publikováno v: PLoS Neglected Tropical Diseases, Vol 14, Iss 12, p e0008930 (2020)

Current efforts to eliminate the neglected tropical diseases onchocerciasis and lymphatic filariasis, caused by the filarial nematodes Onchocerca volvulus and Wuchereria bancrofti or Brugia spp., respectively, are hampered by lack of a short-course m

Externí odkaz: https://doaj.org/article/d4370a71cad149209e66761eb918df85

Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering†

Autor: Rolf Müller, Chantal D. Bader, Jennifer Herrmann, Fabian Panter, Selina Deckarm, Carsten E. Seyfert, Domen Pogorevc, Sebastian Groß

Publikováno v: Chemical Science

The development of new antibiotics is imperative to fight increasing mortality rates connected to infections caused by multidrug-resistant (MDR) bacteria. In this context, Gram-negative pathogens listed in the WHO priority list are particularly probl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7caf1cce69f1723c294ad2b3072a9cf2
http://europepmc.org/articles/PMC8442675

Chemical synthesis of tripeptide thioesters for the biotechnological incorporation into the myxobacterial secondary metabolite argyrin via mutasynthesis

Autor: Roman Sommer, Silke C. Wenzel, Alexander Titz, David Chan Bodin Siebert, Domen Pogorevc, Rolf Müller, Michael J. Hoffmann

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2922-2929 (2019)
Beilstein Journal of Organic Chemistry
Beilstein journal of organic chemistry

The argyrins are secondary metabolites from myxobacteria with antibiotic activity against Pseudomonas aeruginosa. Studying their structure–activity relationship is hampered by the complexity of the chemical total synthesis. Mutasynthesis is a promi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43cf24ca1c3573d08fca5f2debdd625d
https://doaj.org/article/7b6c682e0adb4e48a02cbe71b43e090e

Production optimization and biosynthesis revision of corallopyronin A, a potent anti-filarial antibiotic

Autor: Carolina Schillinger, Domen Pogorevc, Silke C. Wenzel, Rolf Jansen, Rolf Müller, Fabian Panter

Publikováno v: Metabolic Engineering. 55:201-211

Corallopyronins (COR) are α-pyrone antibiotics from myxobacteria representing highly promising lead structures for the development of antibacterial therapeutic agents. Their ability to inhibit RNA polymerase through interaction with the “switch re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73dbfb5bbad324cf6f723a346c2a705
https://doi.org/10.1016/j.ymben.2019.07.010