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In vitro and in vivo detection of mitophagy in human cells, C. elegans, and mice

Autor: Fang, Evandro F., Palikaras, Konstantinos, Sun, Nuo, Fivenson, Elayne M., Spangler, Ryan D., Kerr, Jesse S., Cordonnier, Stephanie A., Hou, Yujun, Dombi, Eszter, Kassahun, Henok, Tavernarakis, Nektarios, Poulton, Joanna, Nilsen, Hilde, Bohr, Vilhelm A.

Mitochondria are the powerhouses of cells and produce cellular energy in the form of ATP. Mitochondrial dysfunction contributes to biological aging and a wide variety of disorders including metabolic diseases, premature aging syndromes, and neurodege

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0fcdf9cda77b75c964da37fa436bd029
https://ora.ox.ac.uk/objects/uuid:113c1bc7-1a06-4082-8888-c7c5b9cdf7e0

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Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations

Autor: Liao, Chunyan, Ashley, Neil, Diot, Alan, Morten, Karl, Phadwal, Kanchan, Williams, Andrew, Fearnley, Ian, Rosser, Lyndon, Lowndes, Jo, Fratter, Carl, Ferguson, David J.P., Vay, Laura, Quaghebeur, Gerardine, Moroni, Isabella, Bianchi, Stefania, Lamperti, Costanza, Downes, Susan M., Sitarz, Kamil S., Flannery, Padraig J., Carver, Janet, Dombi, Eszter, East, Daniel, Laura, Matilde, Reilly, Mary M., Mortiboys, Heather, Prevo, Remko, Campanella, Michelangelo, Daniels, Matthew J., Zeviani, Massimo, Yu-Wai-Man, Patrick, Simon, Anna Katharina, Votruba, Marcela, Poulton, Joanna

Publikováno v: Neurology
Liao, C, Ashley, N, Diot, A, Morten, K, Phadwal, K, Williams, A, Fearnley, I, Rosser, L, Lowndes, J, Fratter, C, Ferguson, D J P, Vay, L, Quaghebeur, G, Moroni, I, Bianchi, S, Lamperti, C, Downes, S M, Sitarz, K S, Flannery, P J, Carver, J, Dombi, E, East, D, Laura, M, Reilly, M M, Mortiboys, H, Prevo, R, Campanella, M, Daniels, M J, Zeviani, M, Yu-Wai-Man, P, Simon, A K, Votruba, M & Poulton, J 2017, ' Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations ', Neurology, vol. 88, no. 2, pp. 131-142 . https://doi.org/10.1212/WNL.0000000000003491
Digital.CSIC. Repositorio Institucional del CSIC
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© 2016 The Author(s).
[Objective]: To investigate mitophagy in 5 patients with severe dominantly inherited optic atrophy (DOA), caused by depletion of OPA1 (a protein that is essential for mitochondrial fusion), compared with healthy controls.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::405f90410b7c65c0cc88235b04994e56

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