Zobrazeno 1 - 10
of 336
pro vyhledávání: '"Dolph L. Hatfield"'
Autor:
Donghyun Kang, Jeeyeon Lee, Jisu Jung, Bradley A. Carlson, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Byung Cheon Lee, Vadim N. Gladyshev, Dolph L. Hatfield, Byeong Jae Lee, Jin-Hong Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Osteoarthritis is caused by the gradual accumulation of oxidative stress in cartilage. Here, the authors show that dysregulation of the selenium metabolic pathway underlies a shift in redox homeostasis in chondrocytes, leading to chronic osteoarthrit
Externí odkaz:
https://doaj.org/article/517ac253fd8341f3a065917ccf49ce58
Autor:
Petra A. Tsuji, Dolph L. Hatfield
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 808 (2022)
The selenium field expanded at a rapid rate for about 45 years, from the mid-1970’s until about 2015 (see [...]
Externí odkaz:
https://doaj.org/article/498c9db9b27f42c4b7540a1245efa068
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 5 (2021)
Selenium is a fascinating element that has a long history, most of which documents it as a deleterious element to health. In more recent years, selenium has been found to be an essential element in the diet of humans, all other mammals, and many othe
Externí odkaz:
https://doaj.org/article/768e20c7fde14eb19f0886f86f07c9e1
Autor:
Sun Hee Yim, Robert A. Everley, Frank A. Schildberg, Sang-Goo Lee, Andrea Orsi, Zachary R. Barbati, Kutay Karatepe, Dmitry E. Fomenko, Petra A. Tsuji, Hongbo R. Luo, Steven P. Gygi, Roberto Sitia, Arlene H. Sharpe, Dolph L. Hatfield, Vadim N. Gladyshev
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1387-1398 (2018)
Summary: Selenof (15-kDa selenoprotein; Sep15) is an endoplasmic reticulum (ER)-resident thioredoxin-like oxidoreductase that occurs in a complex with UDP-glucose:glycoprotein glucosyltransferase. We found that Selenof deficiency in mice leads to ele
Externí odkaz:
https://doaj.org/article/e318695814ee4154b70bd5293aeed048
Autor:
Daniel J. Torres, Matthew W. Pitts, Lucia A. Seale, Ann C. Hashimoto, Katlyn J. An, Ashley N. Hanato, Katherine W. Hui, Stella Maris A. Remigio, Bradley A. Carlson, Dolph L. Hatfield, Marla J. Berry
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11010 (2021)
The role of the essential trace element selenium in hypothalamic physiology has begun to come to light over recent years. Selenium is used to synthesize a family of proteins participating in redox reactions called selenoproteins, which contain a sele
Externí odkaz:
https://doaj.org/article/eec6df4ee8d34bfe8be050ff6f661a6b
Autor:
Jeyoung Bang, Minguk Han, Tack-Jin Yoo, Lu Qiao, Jisu Jung, Jiwoon Na, Bradley A. Carlson, Vadim N. Gladyshev, Dolph L. Hatfield, Jin-Hong Kim, Lark Kyun Kim, Byeong Jae Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11647 (2021)
Selenophosphate synthetase 1 (SEPHS1) plays an essential role in cell growth and survival. However, the underlying molecular mechanisms remain unclear. In the present study, the pathways regulated by SEPHS1 during gastrulation were determined by bioi
Externí odkaz:
https://doaj.org/article/b9546de268e0439ea6d7559a6bd87738
Autor:
Jisu Jung, Yoomin Kim, Jiwoon Na, Lu Qiao, Jeyoung Bang, Dongin Kwon, Tack-Jin Yoo, Donghyun Kang, Lark Kyun Kim, Bradley A. Carlson, Dolph L. Hatfield, Jin-Hong Kim, Byeong Jae Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11646 (2021)
The primary function of selenophosphate synthetase (SEPHS) is to catalyze the synthesis of selenophosphate that serves as a selenium donor during selenocysteine synthesis. In eukaryotes, there are two isoforms of SEPHS (SEPHS1 and SEPHS2). Between th
Externí odkaz:
https://doaj.org/article/fcf946c74f184f6fa9cbf931ace7d468
Autor:
Jessica A. Canter, Sarah E. Ernst, Kristin M. Peters, Bradley A. Carlson, Noelle R. J. Thielman, Lara Grysczyk, Precious Udofe, Yunkai Yu, Liang Cao, Cindy D. Davis, Vadim N. Gladyshev, Dolph L. Hatfield, Petra A. Tsuji
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10651 (2021)
Selenoproteins play important roles in many cellular functions and biochemical pathways in mammals. Our previous study showed that the deficiency of the 15 kDa selenoprotein (Selenof) significantly reduced the formation of aberrant crypt foci (ACF) i
Externí odkaz:
https://doaj.org/article/f82a00ed7a2d46749592bde9f779481e
Autor:
Bradley A. Carlson, Ryuta Tobe, Elena Yefremova, Petra A. Tsuji, Victoria J. Hoffmann, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield, Marcus Conrad
Publikováno v:
Redox Biology, Vol 9, Iss C, Pp 22-31 (2016)
The selenoenzyme glutathione peroxidase 4 (Gpx4) is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, called ferroptosis. To study the
Externí odkaz:
https://doaj.org/article/4225e0ebc41d413cab9402650d9a128d
Autor:
Lucia A. Seale, Ashley N. Ogawa-Wong, Ligia M. Watanabe, Vedbar S. Khadka, Mark Menor, Daniel J. Torres, Bradley A. Carlson, Dolph L. Hatfield, Marla J. Berry
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 611 (2021)
Selenoproteins are a class of proteins with the selenium-containing amino acid selenocysteine (Sec) in their primary structure. Sec is incorporated into selenoproteins via recoding of the stop codon UGA, with specific cis and trans factors required d
Externí odkaz:
https://doaj.org/article/2d43738860a5468c96dcc775e01f2507