Zobrazeno 1 - 10
of 335
pro vyhledávání: '"Dolph L Hatfield"'
Autor:
Anton A Turanov, Robert A Everley, Sandra Hybsier, Kostja Renko, Lutz Schomburg, Steven P Gygi, Dolph L Hatfield, Vadim N Gladyshev
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140353 (2015)
Selenoproteins are a unique group of proteins that contain selenium in the form of selenocysteine (Sec) co-translationally inserted in response to a UGA codon with the help of cis- and trans-acting factors. Mammalian selenoproteins contain single Sec
Externí odkaz:
https://doaj.org/article/e3fc6dc1afeb418fa90106bfb568e949
Autor:
Petra A Tsuji, Bradley A Carlson, Min-Hyuk Yoo, Salvador Naranjo-Suarez, Xue-Ming Xu, Yiwen He, Esther Asaki, Harold E Seifried, William C Reinhold, Cindy D Davis, Vadim N Gladyshev, Dolph L Hatfield
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124487 (2015)
Selenoproteins mediate much of the cancer-preventive properties of the essential nutrient selenium, but some of these proteins have been shown to also have cancer-promoting effects. We examined the contributions of the 15kDa selenoprotein (Sep15) and
Externí odkaz:
https://doaj.org/article/89a6222263d041529431a46c939de9ea
Autor:
Yassin Mahdi, Xue-Ming Xu, Bradley A Carlson, Noelia Fradejas, Paul Günter, Doreen Braun, Eileen Southon, Lino Tessarollo, Dolph L Hatfield, Ulrich Schweizer
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0127349 (2015)
Selenocysteine tRNA 1 associated protein (Trnau1ap) has been characterized as a tRNA[Ser]Sec-binding protein of 43 kDa, hence initially named SECp43. Previous studies reported its presence in complexes containing tRNA[Ser]Sec implying a role of SECp4
Externí odkaz:
https://doaj.org/article/27a8f4b35cf54fc684fcbf085f136c16
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e71427 (2013)
Thioredoxin (Trx) and thioredoxin reductase 1 (TR1) are among the major redox regulators in mammalian cells and have a wide variety of roles, including removal of intracellular reactive oxygen species (ROS) and prevention of cell death. Tumor necrosi
Externí odkaz:
https://doaj.org/article/ac07033f4db5454db16a16a260a08da7
Autor:
Mohamed E Moustafa, Bradley A Carlson, Miriam R Anver, Gerd Bobe, Nianxin Zhong, Jerrold M Ward, Christine M Perella, Victoria J Hoffmann, Keith Rogers, Gerald F Combs, Ulrich Schweizer, Glenn Merlino, Vadim N Gladyshev, Dolph L Hatfield
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57389 (2013)
Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another. To characterize such outcomes in a defined setting, we undertook a control
Externí odkaz:
https://doaj.org/article/d0eb1189879c4990a6bcca0f73d4e755
Autor:
Petra A Tsuji, Bradley A Carlson, Salvador Naranjo-Suarez, Min-Hyuk Yoo, Xue-Ming Xu, Dmitri E Fomenko, Vadim N Gladyshev, Dolph L Hatfield, Cindy D Davis
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e50574 (2012)
Evidence suggests that selenium has cancer preventive properties that are largely mediated through selenoproteins. Our previous observations demonstrated that targeted down-regulation of the 15 kDa selenoprotein (Sep15) in murine colon cancer cells r
Externí odkaz:
https://doaj.org/article/3627b320c12a46f59ffbb0e089cd2185
Autor:
Salvador Naranjo-Suarez, Bradley A Carlson, Petra A Tsuji, Min-Hyuk Yoo, Vadim N Gladyshev, Dolph L Hatfield
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30470 (2012)
Cellular adaptation to hypoxic conditions mainly involves transcriptional changes in which hypoxia inducible factors (HIFs) play a critical role. Under hypoxic conditions, HIF protein is stabilized due to inhibition of the activity of prolyl hydroxyl
Externí odkaz:
https://doaj.org/article/23de2914af7d4f078ba66cffcd5454ee
Autor:
Marco Mariotti, Perry G Ridge, Yan Zhang, Alexei V Lobanov, Thomas H Pringle, Roderic Guigo, Dolph L Hatfield, Vadim N Gladyshev
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33066 (2012)
Selenium is an essential trace element in mammals due to its presence in proteins in the form of selenocysteine (Sec). Human genome codes for 25 Sec-containing protein genes, and mouse and rat genomes for 24.We characterized the selenoproteomes of 44
Externí odkaz:
https://doaj.org/article/5e4a9ae10fbd418b943eb7f0295a4369
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e14564 (2011)
Controlled generation and removal of hydrogen peroxide play important roles in cellular redox homeostasis and signaling. We used a hydrogen peroxide biosensor HyPer, targeted to different compartments, to examine these processes in mammalian cells.Re
Externí odkaz:
https://doaj.org/article/de70c19a2ce74cb6b5ce4a881a6778c7
Autor:
Aniruddha Sengupta, Ulrike F Lichti, Bradley A Carlson, Andrew O Ryscavage, Vadim N Gladyshev, Stuart H Yuspa, Dolph L Hatfield
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12249 (2010)
Dietary selenium is known to protect skin against UV-induced damage and cancer and its topical application improves skin surface parameters in humans, while selenium deficiency compromises protective antioxidant enzymes in skin. Furthermore, skin and
Externí odkaz:
https://doaj.org/article/ad0f65cd83e54b3aa12dd3381a41ec0f