Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?

Autor: Víctor Collado-Díaz, Maria Ángeles Martinez-Cuesta, Maria Amparo Blanch-Ruiz, Ainhoa Sánchez-López, Patricia García-Martínez, José E Peris, Iris Usach, Maria Dolores Ivorra, Alessandra Lacetera, Sonsoles Martín-Santamaría, Juan V. Esplugues, Angeles Alvarez

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The cardiovascular toxicity of Abacavir is related to its purinergic structure. Purinergic P2X7-receptors (P2X7R), characterized by activation by high concentrations of ATP and with high plasticity, seem implicated. We appraise the nature of the inte

Externí odkaz: https://doaj.org/article/b54c2fc280984118ad7cf4027208431e

NT3/TrkC pathway modulates the expression of UCP-1 and adipocyte size in human and murine adipose tissue

Autor: José T. Real, Ana Cristina Requena, Fermí Montó, Andrea Zambrano, M. Dolores Ivorra, Mauricio García-Alonso, Paloma Guillem-Llobat, Isabel Fariñas, Teresa Tejerina, Mª Salomé Sirerol-Piquer, M. Antonia Noguera, María Bové, Pilar D'Ocon

NT3, through activation of its tropomyosin-related kinase receptor C (TrkC), modulates neuronal survival and neural stem cell differentiation. It is widely distributed in peripheral tissues (specially vessels and pancreas) and this ubiquitous pattern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30b8542bd9f6b5572dfd2f015f8c602b
https://doi.org/10.1101/2020.07.24.216374

Activation of (1A)-adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing

Autor: Arce, C, Vicente, D, Segura, V, Flacco, N, Monto, F, Almenar, L, Agueero, Jaime, Rueda, J, Jimenez-Altayo, F, Vila, E, Antonia Noguera, Maria, D'Ocon, P, Dolores Ivorra, Maria

Publikováno v: BRITISH JOURNAL OF PHARMACOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Background and PurposeA NO-mediated desensitization of vasoconstrictor responses evoked by stimulation of (1)-adrenoceptors has been reported in different vessels. We investigated the involvement of each (1)-adrenoceptor subtype and constitutive NOS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::144756b818e31f131f4d93e87ed08704
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=7345

Changes in Adrenoceptors and G-Protein-Coupled Receptor Kinase 2 in L-NAME-Induced Hypertension Compared to Spontaneous Hypertension in Rats

Autor: M. Antonia Noguera, M. Pilar D'ocon, Cristina Arce, Eduardo Oliver, Nicla Flacco, M. Dolores Ivorra

Publikováno v: Journal of Vascular Research. 51:209-220

This work compares the expression of adrenoceptors (ARs) and G-protein-coupled receptor kinase (GRK) 2 (RT-PCR and immunoblotting) and functional responses in conductance (aorta) and resistance vessels (mesenteric resistance arteries; MRA) in two dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea211bde7b2e471ca87d9675a4a993c9
https://doi.org/10.1159/000360400

α1-Adrenoceptors in the rat cerebral cortex: New insights into the characterization of α1L- and α1D-adrenoceptors

Autor: Nicla Flacco, Eduardo Oliver, Vanessa Segura, Pilar D'Ocon, Domingo Barettino, Maria Dolores Ivorra

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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36 p., figuras y tablas, bibliografía
Among the three alpha1-adrenoceptor subtypes (alpha1A, alpha1B and alpha1D) a peculiar intracellular localization and poor coupling to membrane signals of cloned alpha1D-adrenoceptor has been reported. In a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6e15a75965bb426c0904d9e19eeae3
https://doi.org/10.1016/j.ejphar.2010.05.016