Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Dolores Gonzalez, Pacanowska"'
Autor:
Dana M. Klug, Nelly El-Sakkary, Cristina Bosch-Navarrete, Rosario Diaz-Gonzalez, Gloria Ceballos-Pérez, Guiomar Pérez-Moreno, Jeremiah D. Momper, Carlos Cordon-Obras, Francisco Gamarro, Dolores Gonzalez Pacanowska, Maria Santos Martinez-Martinez, Lori Ferrins, Conor R. Caffrey, Eftychia M. Mavrogiannaki, Katherine C. Forbes, Raquel García-Hernández, Claudia Gómez-Liñán, Miguel Navarro, Andreu Saura, Luis M. Ruiz-Pérez, Pilar Manzano, Ali Syed, Lisseth Silva, Michael P. Pollastri
Publikováno v:
J Med Chem
Neglected tropical diseases such as human African trypanosomiasis (HAT) are prevalent primarily in tropical climates and among populations living in poverty. Historically, the lack of economic incentive to develop new treatments for these diseases ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9937aba3a31ba3131cffe3becb644f09
https://doi.org/10.1021/acs.jmedchem.1c00674
https://doi.org/10.1021/acs.jmedchem.1c00674
Autor:
Na Shang, Qian Li, Tzu-Ping Ko, Hsiu-Chien Chan, Jikun Li, Yingying Zheng, Chun-Hsiang Huang, Feifei Ren, Chun-Chi Chen, Zhen Zhu, Melina Galizzi, Zhu-Hong Li, Carlos A Rodrigues-Poveda, Dolores Gonzalez-Pacanowska, Phercyles Veiga-Santos, Tecia Maria Ulisses de Carvalho, Wanderley de Souza, Julio A Urbina, Andrew H-J Wang, Roberto Docampo, Kai Li, Yi-Liang Liu, Eric Oldfield, Rey-Ting Guo
Publikováno v:
PLoS Pathogens, Vol 10, Iss 5, p e1004114 (2014)
Trypanosomatid parasites are the causative agents of many neglected tropical diseases and there is currently considerable interest in targeting endogenous sterol biosynthesis in these organisms as a route to the development of novel anti-infective dr
Externí odkaz:
https://doaj.org/article/7aa1b1fa08484e2681faf43225862b98
Autor:
Justin R, Harrison, Sandipan, Sarkar, Shahienaz, Hampton, Jennifer, Riley, Laste, Stojanovski, Christer, Sahlberg, Pia, Appelqvist, Jessey, Erath, Vinodhini, Mathan, Ana, Rodriguez, Marcel, Kaiser, Dolores Gonzalez, Pacanowska, Kevin D, Read, Nils Gunnar, Johansson, Ian H, Gilbert
Publikováno v:
Journal of medicinal chemistry. 63(6)
Chagas disease is caused by the protozoan parasite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3be7b1a0700258bb2e44498c433ca4e
https://pubmed.ncbi.nlm.nih.gov/32134269
https://pubmed.ncbi.nlm.nih.gov/32134269
Autor:
Marcel Kaiser, Justin R. Harrison, Vinodhini Mathan, Sandipan Sarkar, Ian H. Gilbert, Laste Stojanovski, Christer Sahlberg, Jennifer Riley, Ana Rodriguez, Nils Gunnar Johansson, Pia Appelqvist, Jessey Erath, Dolores Gonzalez Pacanowska, Shahienaz E. Hampton, Kevin D. Read
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronically infected patients. The current treatment for Cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e827355cb5490d1a755ca354b64d4ab
http://hdl.handle.net/10261/216294
http://hdl.handle.net/10261/216294
Autor:
Raquel García-Hernández, Domingo I. Rojas-Barros, Michael P. Pollastri, Conor R. Caffrey, Gloria Ceballos-Pérez, Pilar Manzano, Luis M. Ruiz-Pérez, Maria Santos Martinez-Martinez, Lori Ferrins, Carlos Cordon-Obras, Westley Tear, Seema Bag, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Francisco Gamarro, Dolores Gonzalez Pacanowska, Miguel Navarro
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
From a high-throughput screen of 42 444 knownhuman kinases inhibitors, a pyrazolo[1,5-b]pyridazine scaffold wasidentified to begin optimization for the treatment of human Africantrypanosomiasis. Previously reported data for analogous com-pounds again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155e0c5832d1468a3b1529e2bdbaaaa5
http://hdl.handle.net/10261/213997
http://hdl.handle.net/10261/213997
Autor:
Westley F, Tear, Seema, Bag, Rosario, Diaz-Gonzalez, Gloria, Ceballos-Pérez, Domingo I, Rojas-Barros, Carlos, Cordon-Obras, Guiomar, Pérez-Moreno, Raquel, García-Hernández, Maria Santos, Martinez-Martinez, Luis Miguel, Ruiz-Perez, Francisco, Gamarro, Dolores, Gonzalez Pacanowska, Conor R, Caffrey, Lori, Ferrins, Pilar, Manzano, Miguel, Navarro, Michael P, Pollastri
Publikováno v:
Journal of Medicinal Chemistry
From a high-throughput screen of 42 444 known human kinases inhibitors, a pyrazolo[1,5-b]pyridazine scaffold was identified to begin optimization for the treatment of human African trypanosomiasis. Previously reported data for analogous compounds aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0876a67d81031f382038cabde3810dab
https://pubmed.ncbi.nlm.nih.gov/31846577
https://pubmed.ncbi.nlm.nih.gov/31846577
Autor:
Raquel García-Hernández, Maria Santos Martinez-Martinez, Domingo I. Rojas-Barros, Guiomar Pérez-Moreno, Lori Ferrins, Miguel Navarro, Conor R. Caffrey, Luis Miguel Ruiz, Francisco Gamarro, Dolores Gonzalez Pacanowska, Rosario Diaz, Gloria Ceballos, Laura Tschiegg, Pilar Manzano, Michael P. Pollastri, Dana M. Klug
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
J Med Chem
instname
J Med Chem
Human African trypanosomiasis (HAT) is a neglected tropical disease caused by infection with either of two subspecies of the parasite Trypanosoma brucei. Due to a lack of economic incentive to develop new drugs, current treatments have severe limitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b9ccaa660040696710cbeaac98f25e
http://hdl.handle.net/10261/212905
http://hdl.handle.net/10261/212905
Publikováno v:
Comprehensive Analysis of Parasite Biology: From Metabolism to Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19c3456416275e2dedc2894387f3fe70
https://doi.org/10.1002/9783527694082.ch6
https://doi.org/10.1002/9783527694082.ch6
Autor:
Marcel Kaiser, Dolores Gonzalez Pacanowska, Alex Musso-Buendia, Ian H. Gilbert, Reto Brun, Luis M. Ruiz-Pérez, Orla McCarthy, Nils Gunnar Johansson
Publikováno v:
European Journal of Medicinal Chemistry. 44:678-688
The ubiquitous enzyme dUTP nucleotidohydrolase (dUTPase) catalyses the hydrolysis of dUTP to dUMP and can be considered as the first line of defence against incorporation of uracil into DNA. Inhibition of this enzyme results in over-incorporation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa649aa56dd3e77e9489983621f973b0
https://doi.org/10.1016/j.ejmech.2008.05.018
https://doi.org/10.1016/j.ejmech.2008.05.018
Autor:
Ian H. Gilbert, Carlos Rodrigues, Marcel Kaiser, Silvia Orenes Lorente, Simon Jones, Luis M. Ruiz Perez, Aura Caldera, Julio A. Urbina, Carmen Jiménez, Reto Brun, Dolores Gonzalez Pacanowska, Wanderley da Souza, Ludovic Gros, Simon Cammerer, Juliany Cola Fernandes Rodrigues
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:4049-4061
There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cause these diseases is sterol biosynthesis. This pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3edf1815d5d344838ea0d03f2e54115
https://doi.org/10.1128/aac.00205-07
https://doi.org/10.1128/aac.00205-07