Výsledky vyhledávání - "Dolores, Fregona"

Akademický článek

Binuclear Heteroleptic Ru(III) Dithiocarbamate Complexes: A Step towards Tunable Antiproliferative Agents

Autor: Andrea E. Gallio, Leonardo Brustolin, Nicolò Pettenuzzo, Dolores Fregona

Publikováno v: Inorganics, Vol 10, Iss 3, p 37 (2022)

Binuclear dithiocarbamate complexes of Ru(III) are promising candidates in the search for outstanding metal-based anticancer agents. While different dithiocarbamates have shown ligand-dependent cytotoxicity in homoleptic binuclear Ru(III) complexes,

Externí odkaz: https://doaj.org/article/2c9417ad22ac41549d9b641445ed082e

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Akademický článek

Gold(III) to Ruthenium(III) Metal Exchange in Dithiocarbamato Complexes Tunes Their Biological Mode of Action for Cytotoxicity in Cancer Cells

Autor: Maria Dalla Pozza, Christophe Orvain, Leonardo Brustolin, Nicolò Pettenuzzo, Chiara Nardon, Christian Gaiddon, Dolores Fregona

Publikováno v: Molecules, Vol 26, Iss 13, p 4073 (2021)

Malignant tumors have affected the human being since the pharaoh period, but in the last century the incidence of this disease has increased due to a large number of risk factors, including deleterious lifestyle habits (i.e., smoking) and the higher

Externí odkaz: https://doaj.org/article/939376302eae4ffbb2670cac01a8bc13

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Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3

Autor: Ionica Masgras, Giuseppe Cannino, Francesco Ciscato, Carlos Sanchez-Martin, Fereshteh Babaei Darvishi, Francesca Scantamburlo, Marco Pizzi, Alessio Menga, Dolores Fregona, Alessandra Castegna, Andrea Rasola

Publikováno v: Cell Death & Differentiation. 29:1996-2008

Neurofibromin loss drives neoplastic growth and a rewiring of mitochondrial metabolism. Here we report that neurofibromin ablation dampens expression and activity of NADH dehydrogenase, the respiratory chain complex I, in an ERK-dependent fashion, de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d4298155fd8b5a531d1b2989b2a2df
https://doi.org/10.1038/s41418-022-00991-4

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Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD

Autor: Ionica, Masgras, Giuseppe, Cannino, Francesco, Ciscato, Carlos, Sanchez-Martin, Fereshteh Babaei, Darvishi, Francesca, Scantamburlo, Marco, Pizzi, Alessio, Menga, Dolores, Fregona, Alessandra, Castegna, Andrea, Rasola

Publikováno v: Cell death and differentiation. 29(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0312540414d6006da675a167d28ecf40
https://pubmed.ncbi.nlm.nih.gov/35393510

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CuIIand AuIIIComplexes with Glycoconjugated Dithiocarbamato Ligands for Potential Applications in Targeted Chemotherapy

Autor: Alberto Gambalunga, Federica Chiara, Barbara Biondi, Dolores Fregona, Chiara Nardon, Leonardo Brustolin, Andrea Trevisan, Nicolò Pettenuzzo, Elisa Coltri

Publikováno v: ChemMedChem
14 (2019): 1162–1172. doi:10.1002/cmdc.201900226
info:cnr-pdr/source/autori:Pettenuzzo, Nicolo; Brustolin, Leonardo; Coltri, Elisa; Gambalunga, Alberto; Chiara, Federica; Trevisan, Andrea; Biondi, Barbara; Nardon, Chiara; Fregona, Dolores/titolo:Cu-II and Au-III Complexes with Glycoconjugated Dithiocarbamato Ligands for Potential Applications in Targeted Chemotherapy/doi:10.1002%2Fcmdc.201900226/rivista:ChemMedChem (Print)/anno:2019/pagina_da:1162/pagina_a:1172/intervallo_pagine:1162–1172/volume:14

This work is focused on the synthesis, characterization, and preliminary biological evaluation of bio-conjugated Au-III and Cu-II complexes with the aim of overcoming the well-known side effects of chemotherapy by improving the selective accumulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578f3bccb791ec0d0cf39e8b20c9a839
https://doi.org/10.1002/cmdc.201900226

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Au(iii)-Proline derivatives exhibiting selective antiproliferative activity against HepG2/SB3 apoptosis-resistant cancer cells

Autor: Nicolò Pettenuzzo, Santina Quarta, Patrizia Pontisso, Dolores Fregona, Luciano Marchiò, Barbara Biondi, Chiara Nardon, Leonardo Brustolin

Publikováno v: Dalton transactions (2003. Online) 48 (2019): 16017–16025. doi:10.1039/c9dt03036k
info:cnr-pdr/source/autori:Brustolin L.; Pettenuzzo N.; Nardon C.; Quarta S.; Marchio L.; Biondi B.; Pontisso P.; Fregona D./titolo:Au(iii)-Proline derivatives exhibiting selective antiproliferative activity against HepG2%2FSB3 apoptosis-resistant cancer cells/doi:10.1039%2Fc9dt03036k/rivista:Dalton transactions (2003. Online)/anno:2019/pagina_da:16017/pagina_a:16025/intervallo_pagine:16017–16025/volume:48

This paper deals with the combination of a proline-based moiety with biologically active gold centers in the oxidation states +1 and +3. In particular, six Au(i)/(iii)-proline dithiocarbamato (DTC) complexes with general formulae [Au(DTC)2] and [AuII

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ad537f821181056fc62313ab20abbb
https://doi.org/10.1039/c9dt03036k

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Akademický článek

Gold(III)-dithiocarbamato peptidomimetics in the forefront of the targeted anticancer therapy: preclinical studies against human breast neoplasia.

Autor: Chiara Nardon, Sara M Schmitt, Huanjie Yang, Jian Zuo, Dolores Fregona, Q Ping Dou

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84248 (2014)

Since the serendipitous discovery of cisplatin, platinum-based drugs have become well-established antitumor agents, despite the fact that their clinical use is limited by many severe side-effects. In order to both improve the chemotherapeutic index a

Externí odkaz: https://doaj.org/article/ffc680e37eae45faa2fd6170d21def94

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Labelled micelles for the delivery of cytotoxic Cu(II) and Ru(III) compounds in the treatment of aggressive orphan cancers: design and biological in vitro data

Autor: Stefano Merigliano, Dolores Fregona, Antonio Rosato, Patrizia Pontisso, Santina Quarta, Chiara Nardon, Nicolò Pettenuzzo, Pierfranco Conte, Isabella Monia Montagner, Leonardo Brustolin

Publikováno v: Università degli Studi di Padova-IRIS

A recent study on our metal-dithiocarbamato complexes pointed out the antiproliferative properties and the druglikeness of some new patented derivatives. In this work, the best compounds have been encapsulated in micellar nanocarriers, being also car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba52805fdb358a79425c53f82a05cd3f
http://hdl.handle.net/11562/1062969

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Anticancer Gold(III) Peptidomimetics: From Synthesis to in vitro and ex vivo Biological Evaluations

Autor: Marco Crisma, Dolores Fregona, Chiara Nardon, Daniele Dalzoppo, Fernando Formaggio, Angela Casini, Giulia Boscutti, Lisa Dalla Via, Luciano Marchiò, Barbara Biondi

Publikováno v: ChemMedChem
13 (2018): 1131–1145. doi:10.1002/cmdc.201800098
info:cnr-pdr/source/autori:Boscutti, Giulia; Nardon, Chiara; Marchio, Luciano; Crisma, Marco; Biondi, Barbara; Dalzoppo, Daniele; Dalla Via, Lisa; Formaggio, Fernando; Casini, Angela; Fregona, Dolores/titolo:Anticancer Gold(III) Peptidomimetics: From Synthesis to in vitro and ex vivo Biological Evaluations/doi:10.1002%2Fcmdc.201800098/rivista:ChemMedChem (Print)/anno:2018/pagina_da:1131/pagina_a:1145/intervallo_pagine:1131–1145/volume:13
ChemMedChem, 13(11), 1131-1145. WILEY-V C H VERLAG GMBH

Five new Au-III-peptidodithiocarbamato complexes of the type [(AuBr2)-Br-III(dtc-AA(1)-AA(2)-OR] (in which AA(1)=N-methylglycine (Sar), l/d-Pro; AA(2)=l/d-Ala, -aminoisobutyric acid (Aib); R=OtBu, triethylene glycol methyl ether), differing with rega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c2dfdd81022f6da3fcabbdfbeabca5
https://doi.org/10.1002/cmdc.201800098

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