Zobrazeno 1 - 10
of 711
pro vyhledávání: '"Dolga A."'
Linear recurrent models, such as State Space Models (SSMs) and Linear Recurrent Units (LRUs), have recently shown state-of-the-art performance on long sequence modelling benchmarks. Despite their success, they come with a number of drawbacks, most no
Externí odkaz:
http://arxiv.org/abs/2407.07239
Code revert prediction, a specialized form of software defect detection, aims to forecast or predict the likelihood of code changes being reverted or rolled back in software development. This task is very important in practice because by identifying
Externí odkaz:
http://arxiv.org/abs/2403.09507
Log analysis and monitoring are essential aspects in software maintenance and identifying defects. In particular, the temporal nature and vast size of log data leads to an interesting and important research question: How can logs be summarised and mo
Externí odkaz:
http://arxiv.org/abs/2403.08358
The time complexity of the standard attention mechanism in a transformer scales quadratically with the length of the sequence. We introduce a method to reduce this to linear scaling with time, based on defining attention via latent vectors. The metho
Externí odkaz:
http://arxiv.org/abs/2402.17512
The physics of how molecules, organelles, and foreign objects move within living cells has been extensively studied in organisms ranging from bacteria to human cells. In mammalian cells, in particular, cellular vesicles move across the cell using mot
Externí odkaz:
http://arxiv.org/abs/2211.02019
Autor:
Deng Chen, Chunlong Zhao, Jianqiu Zhang, Catharina W. J. Knol, Angelina Osipyan, Nad'a Majerníková, Tingting Chen, Zhangping Xiao, Jeaunice Adriana, Andrew J. Griffith, Abel Soto Gamez, Petra E. van derWouden, Robert P. Coppes, Amalia M. Dolga, Hidde J. Haisma, Frank J. Dekker
Publikováno v:
Advanced Science, Vol 11, Iss 32, Pp n/a-n/a (2024)
Abstract Ferroptosis is a form of regulated cell death that can be modulated by small molecules and has the potential for the development of therapeutics for oncology. Although excessive lipid peroxidation is the defining hallmark of ferroptosis, DNA
Externí odkaz:
https://doaj.org/article/5f1b5535d1c64d3381cee0b2777a4e5b
Autor:
Isabella Cattani-Cavalieri, Marina Trombetta-Lima, Hong Yan, Ana L. Manzano-Covarrubias, Hoeke A. Baarsma, Asmaa Oun, Melissa Mol van der Veen, Emily Oosterhout, Amalia M. Dolga, Rennolds S. Ostrom, Samuel Santos Valenca, Martina Schmidt
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Introduction: Air pollution from diesel combustion is linked in part to the generation of diesel exhaust particles (DEP). DEP exposure induces various processes, including inflammation and oxidative stress, which ultimately contribute to a decline in
Externí odkaz:
https://doaj.org/article/4610bf6e0c5a40caa4eaa192573cc12d
Autor:
Alejandro Marmolejo-Garza, Laurent Chatre, Deborah L. Croteau, Alejandro Herron-Bedoya, Minh Danh Anh Luu, Benoit Bernay, Julien Pontin, Vilhelm A. Bohr, Erik Boddeke, Amalia M. Dolga
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106645- (2024)
Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust cognitive benefits and alleviates neuroinflammation in Alzheimer's Disease (AD) mouse models without decreasing beta-amyloid plaque pathology. Su
Externí odkaz:
https://doaj.org/article/4ee99df2197a4223b78289600027be29
Autor:
Alejandro Marmolejo-Garza, Inge E. Krabbendam, Minh Danh Anh Luu, Famke Brouwer, Marina Trombetta-Lima, Osman Unal, Shane J. O’Connor, Naďa Majerníková, Carolina R. S. Elzinga, Cristina Mammucari, Martina Schmidt, Muniswamy Madesh, Erik Boddeke, Amalia M. Dolga
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-15 (2023)
Abstract Ferroptosis is an iron- and reactive oxygen species (ROS)-dependent form of regulated cell death, that has been implicated in Alzheimer’s disease and Parkinson’s disease. Inhibition of cystine/glutamate antiporter could lead to mitochond
Externí odkaz:
https://doaj.org/article/691ff9c44b724f72bdd4f4130f56e6a5
Autor:
Angélica María Sabogal-Guáqueta, Alejandro Marmolejo-Garza, Marina Trombetta-Lima, Asmaa Oun, Jasmijn Hunneman, Tingting Chen, Jari Koistinaho, Sarka Lehtonen, Arjan Kortholt, Justina C. Wolters, Barbara M. Bakker, Bart J. L. Eggen, Erik Boddeke, Amalia Dolga
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-24 (2023)
Abstract Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory stimuli. This metabolic process involves a switch from oxidative phosphorylation (OXPHOS) to glycolysis or alterations in other metabolic pathways. However
Externí odkaz:
https://doaj.org/article/84b22256347c40f5852d44e2ee2ceacc