Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Doley J. Hong"'
Autor:
Charleen Miller, Glenn Croston, Manoj P. Samant, Jean Rivier, Doley J. Hong, Steven C. Koerber, Catherine Rivier
Publikováno v:
The Journal of Peptide Research. 65:284-291
Degarelix is a potent very long-acting GnRH antagonist after subcutaneous administration. In this paper, we describe the synthesis of two analogs of degarelix incorporating racemic 3-(2-methoxy-5-pyridyl)-alanine (2-OMe-5Pal, 5) at position 3. The tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13ef8700798482119eb5b341110196ec
https://doi.org/10.1111/j.1399-3011.2005.00219.x
https://doi.org/10.1111/j.1399-3011.2005.00219.x
Publikováno v:
Journal of Medicinal Chemistry. 49:3536-3543
Novel degarelix (Fe200486) analogues were screened for antagonism of GnRH-induced response (IC(50)) in a reporter gene assay. Inhibition of luteinizing hormone release over time was measured in the castrated male rat. N(omega)-Hydroxy- and N(omega)-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e23b63d75445184904f988d77f72d3
https://doi.org/10.1021/jm060240a
https://doi.org/10.1021/jm060240a
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2894-2897
Several azaline B analogs (2–10) were synthesized and evaluated for their ability to antagonize GnRH in vitro and for duration of action in inhibiting luteinizing hormone secretion in a castrated male rat assay in vivo. Analogs, 8 (IC50 = 1.85 nM),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f4cb5f8f38fdd43f641cd7a4b873d3c
https://doi.org/10.1016/j.bmcl.2005.03.085
https://doi.org/10.1016/j.bmcl.2005.03.085
Autor:
Doley J. Hong, Amy P. Sing, Philip D. Greenberg, Wendy Batten, Richard F. Ambinder, Effie W. Petersdorf, Michael C. Jensen
Publikováno v:
Blood. 89:1978-1986
A subset of Hodgkin's disease (HD) patients have detectable Epstein-Barr virus (EBV) genomes in the malignant Reed-Sternberg (R-S) cells. R-S cells express only a limited set of latent EBV proteins, but only LMP1 and LMP2 can potentially elicit a CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::011381d05840ed12ed7b733b33a8a9da
https://doi.org/10.1182/blood.v89.6.1978
https://doi.org/10.1182/blood.v89.6.1978
Publikováno v:
Understanding Biology Using Peptides ISBN: 9780387265698
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f0ee3a0034562ea979deadee911559f
https://doi.org/10.1007/978-0-387-26575-9_186
https://doi.org/10.1007/978-0-387-26575-9_186
Autor:
Richard White, Doley J. Hong, Manoj P. Samant, Jean Rivier, Glenn Croston, P. Michael Conn, Jo Ann Janovick
Publikováno v:
Journal of medicinal chemistry. 50(9)
A series of acyline analogues incorporating l- and d-isomers of S-arylated/alkylated norcysteines [Ncy(R), where R is 2-naphthyl, methyl, and isopropyl] at positions 1, 4, 7, and 10 were synthesized. Some of these analogues were mono- and dioxidized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3e114febe4ac61ef28f345c48318ff
https://pubmed.ncbi.nlm.nih.gov/17402723
https://pubmed.ncbi.nlm.nih.gov/17402723
Degarelix (FE200486, Ac-d-2Nal(1)-d-4Cpa(2)-d-3Pal(3)-Ser(4)-4Aph(l-Hor)(5)-d-4Aph(Cbm)(6)-Leu(7)-ILys(8)-Pro(9)-d-Ala(10)-NH(2)) is a potent and very long acting antagonist of gonadotropin-releasing hormone (GnRH) after subcutaneous administration i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b333bfa146a3da568f4607b3fd5d89
https://europepmc.org/articles/PMC2593149/
https://europepmc.org/articles/PMC2593149/
Publikováno v:
Biopolymers. 80(2-3)
Gonadotropin-releasing hormone (GnRH) antagonists with high potency and improved duration of action are needed for potential clinical applications. We synthesized four new antagonists (2–5) of GnRH homologues to Azaline B (1), with a common core se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513ed6a0ac7243bbf92129720a90af0d
https://pubmed.ncbi.nlm.nih.gov/15614806
https://pubmed.ncbi.nlm.nih.gov/15614806
Autor:
Carol M. Warby, Javier Tello, Karen O. Akinsanya, Doley J. Hong, George O. Mackie, Nancy M. Sherwood, Jean Rivier, Wylie Vale, Judit Erchegyi, Bruce A. Adams
Publikováno v:
Endocrinology. 144(5)
GnRH is the key regulator of the reproductive axis in vertebrates, but little is known about GnRH before the origin of vertebrates. We have identified two genes encoding GnRH in a protochordate, Ciona intestinalis, thought to be related to the ancest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ddb236aee0d8bf4c7c7b91480552c1
https://pubmed.ncbi.nlm.nih.gov/12697698
https://pubmed.ncbi.nlm.nih.gov/12697698
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 166(4)
Transgenic (TG) mice were generated selectively expressing the gag protein of Friend murine leukemia virus (FMuLV) in the liver. FMuLVgag is also expressed by the FBL leukemia, and is the immunodominant tumor Ag of the CD8+ T cell response in C57BL/6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b807ce4dfd1851a75c34a5372a57a4
https://pubmed.ncbi.nlm.nih.gov/11160355
https://pubmed.ncbi.nlm.nih.gov/11160355