Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Dolena R. Ledee"'
Autor:
Wesley Wang, Dolena R. Ledee
Publikováno v:
Biochem Biophys Res Commun
Thyroid hormones (THs) play a critical role in the metabolic phenotype of the heart; and most of the effects involve transcriptional regulation via thyroid hormone receptors (TRs). TRs ability to form combinatorial complexes with an array of partners
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae5d3e4dad1f46dcd4195ebeab6dd6c
https://pubmed.ncbi.nlm.nih.gov/34474245
https://pubmed.ncbi.nlm.nih.gov/34474245
Publikováno v:
Physiological Reports
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Protein posttranslational modifications (PTMs) by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) rise during pressure‐overload hypertrophy (POH) to affect hypertrophic growth. The hexosamine biosynthesis pathway (HBP) branches from glycolysis t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f0f933823547e39f2b52537f7f2d42
https://doi.org/10.14814/phy2.14965
https://doi.org/10.14814/phy2.14965
Publikováno v:
Proteome Science
Proteome Science, Vol 18, Iss 1, Pp 1-13 (2020)
Proteome Science, Vol 18, Iss 1, Pp 1-13 (2020)
BackgroundSex and age have substantial influence on thyroid function. Sex influences the risk and clinical expression of thyroid disorders (TDs), with age a proposed trigger for the development of TDs. Cardiac function is affected by thyroid hormone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcc8e680c038f627651f010f586fea57
https://pubmed.ncbi.nlm.nih.gov/33372611
https://pubmed.ncbi.nlm.nih.gov/33372611
Autor:
Ljiljana Paša-Tolić, Heather M. Brewer, Dolena R Ledee, Masaki Kajimoto, MinA Kang, Michael A. Portman, Samuel O. Purvine
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 313:H125-H137
Ischemia-reperfusion (I/R) results in altered metabolic and molecular responses, and phosphorylation is one of the most noted regulatory mechanisms mediating signaling mechanisms during physiological stresses. To expand our knowledge of the potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b58c483025b9651a2079fd24f0b6ad
https://doi.org/10.1152/ajpheart.00842.2016
https://doi.org/10.1152/ajpheart.00842.2016
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Protein posttranslational modifications by O ‐linked β‐N‐acetylglucosamine (O‐GlcNAc) increase with cardiac hypertrophy, yet the functional effects of these changes are incompletely understood. In other organs, O‐GlcNAc promotes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3192837c584b58912e03afdb19de0f
http://europepmc.org/articles/PMC6585351
http://europepmc.org/articles/PMC6585351
Autor:
Masaki Kajimoto, Michael A. Portman, Coral N. Ringer, Gail H. Deutsch, Jonathan A. Poli, James B Fink, Rajesh Uthamanthil, Juergen W. Pfeiffer, Joseph Zimmerman, Robert M DiBlasi, Patrik Malone, Dolena R. Ledee, David N Crotwell
Publikováno v:
Critical Care Explorations
Critical Care Explorations, Vol 3, Iss 2, p e0338 (2021)
Critical Care Explorations, Vol 3, Iss 2, p e0338 (2021)
Supplemental Digital Content is available in the text.
Objectives: Effective treatment options for surfactant therapy in acute respiratory distress syndrome and coronavirus disease 2019 have not been established. To conduct preclinical studies i
Objectives: Effective treatment options for surfactant therapy in acute respiratory distress syndrome and coronavirus disease 2019 have not been established. To conduct preclinical studies i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e5fa5c26ae50758332006ca88af73e
https://doi.org/10.1097/cce.0000000000000338
https://doi.org/10.1097/cce.0000000000000338
Autor:
Masaki Kajimoto, Isabelle Robillard-Frayne, Aaron K Olson, Nancy G. Isern, Christine Des Rosiers, Dolena R. Ledee, Michael A. Portman
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 36:1992-2004
Deep hypothermic circulatory arrest is often required for the repair of complex congenital cardiac defects in infants. However, deep hypothermic circulatory arrest induces neuroapoptosis associated with later development of neurocognitive abnormaliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74077120e5ad51ec9e9e055fc253609a
https://doi.org/10.1177/0271678x16666846
https://doi.org/10.1177/0271678x16666846
Autor:
Masaki Kajimoto, Phil G. Morgan, Nancy G. Isern, Margaret M. Sedensky, Christine Des Rosiers, Dolena R. Ledee, Douglas B. Atkinson, Michael A. Portman, Ernst Bernhard Kayser
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 34:514-521
Anesthetics used in infants and children are implicated in the development of neurocognitive disorders. Although propofol induces neuroapoptosis in developing brain, the underlying mechanisms require elucidation and may have an energetic basis. We st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622297019870169d0392846c7053a3b7
https://doi.org/10.1038/jcbfm.2013.229
https://doi.org/10.1038/jcbfm.2013.229
Autor:
Masaki Kajimoto, Chun Xu, Michael A. Portman, Hidemi Kajimoto, Nancy G. Isern, Dolena R. Ledee
Publikováno v:
Circulation Journal. 78:2867-2875
Background Extracorporeal membrane oxygenation (ECMO) provides a rescue for children with severe cardiac failure. It has previously been shown that triiodothyronine (T3) improves cardiac function by modulating pyruvate oxidation during weaning. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9104a01349bc92293c437ca7f36602a1
https://doi.org/10.1253/circj.cj-14-0821
https://doi.org/10.1253/circj.cj-14-0821
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 312(4)
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) provides hemodynamic rescue for patients encountering right or left ventricular (RV or LV) decompensation, particularly after surgery for congenital heart defects. ECMO, supported metabolical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3fe8d6221cf65d0675014d84695ffd
https://pubmed.ncbi.nlm.nih.gov/28159812
https://pubmed.ncbi.nlm.nih.gov/28159812