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A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia.

Autor: Czardybon W; Selvita S.A., Krakow, Poland., Windak R; Selvita S.A., Krakow, Poland., Gołas A; Selvita S.A., Krakow, Poland., Gałęzowski M; Selvita S.A., Krakow, Poland., Sabiniarz A; Selvita S.A., Krakow, Poland., Dolata I; Selvita S.A., Krakow, Poland., Salwińska M; Selvita S.A., Krakow, Poland., Guzik P; Selvita S.A., Krakow, Poland., Zawadzka M; Selvita S.A., Krakow, Poland., Gabor-Worwa E; Selvita S.A., Krakow, Poland., Winnik B; Selvita S.A., Krakow, Poland., Żurawska M; Selvita S.A., Krakow, Poland., Kolasińska E; Selvita S.A., Krakow, Poland., Wincza E; Selvita S.A., Krakow, Poland., Bugaj M; Selvita S.A., Krakow, Poland., Danielewicz M; Selvita S.A., Krakow, Poland., Majewska E; Selvita S.A., Krakow, Poland., Mazan M; Selvita S.A., Krakow, Poland., Dubin G; Malopolska Centre of Biotechnology, Krakow, Poland., Noyszewska-Kania M; Dept. of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Jabłońska E; Dept. of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Szydłowski M; Dept. of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Sewastianik T; Dept. of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Puła B; Dept. of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Szumera-Ciećkiewicz A; Dept. of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Prochorec-Sobieszek M; Dept. of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Mądro E; Dept. of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Lech-Marańda E; Dept. of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.; Dept. of Hematology and Transfusion Medicine, Centre of Postgraduate Medical Education, Marymoncka, Warsaw, Poland., Warzocha K; Dept. of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Tamburini J; Institut Cochin, Département Développement, Reproduction, Cancer, Paris, France.; Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.; Equipe Labellisée, Ligue Nationale Contre le Cancer (LNCC), Paris, France., Juszczyński P; Dept. of Experimental Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Brzózka K; Selvita S.A., Krakow, Poland.

Publikováno v: Oncotarget [Oncotarget] 2018 Mar 30; Vol. 9 (24), pp. 16917-16931. Date of Electronic Publication: 2018 Mar 30 (Print Publication: 2018).

SEL120-34A is a novel CDK8 inhibitor active in AML cells with high levels of serine phosphorylation of STAT1 and STAT5 transactivation domains.

Autor: Rzymski T; R&D Department, Selvita S.A., Kraków, Poland., Mikula M; Department of Genetics, Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland., Żyłkiewicz E; R&D Department, Selvita S.A., Kraków, Poland., Dreas A; R&D Department, Selvita S.A., Kraków, Poland., Wiklik K; R&D Department, Selvita S.A., Kraków, Poland., Gołas A; R&D Department, Selvita S.A., Kraków, Poland., Wójcik K; R&D Department, Selvita S.A., Kraków, Poland., Masiejczyk M; R&D Department, Selvita S.A., Kraków, Poland., Wróbel A; R&D Department, Selvita S.A., Kraków, Poland., Dolata I; R&D Department, Selvita S.A., Kraków, Poland., Kitlińska A; R&D Department, Selvita S.A., Kraków, Poland., Statkiewicz M; Department of Genetics, Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland., Kuklinska U; Department of Genetics, Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland., Goryca K; Department of Genetics, Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland., Sapała Ł; R&D Department, Selvita S.A., Kraków, Poland., Grochowska A; Department of Gastroenterology, Hepatology and Clinical Oncology, Medical Center for Postgraduate Education, Warsaw, Poland., Cabaj A; Department of Genetics, Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland.; Laboratory of Bioinformatics, Nencki Institute of Experimental Biology, Warsaw, Poland., Szajewska-Skuta M; R&D Department, Selvita S.A., Kraków, Poland., Gabor-Worwa E; R&D Department, Selvita S.A., Kraków, Poland., Kucwaj K; R&D Department, Selvita S.A., Kraków, Poland., Białas A; R&D Department, Selvita S.A., Kraków, Poland., Radzimierski A; R&D Department, Selvita S.A., Kraków, Poland., Combik M; R&D Department, Selvita S.A., Kraków, Poland., Woyciechowski J; R&D Department, Selvita S.A., Kraków, Poland., Mikulski M; R&D Department, Selvita S.A., Kraków, Poland., Windak R; R&D Department, Selvita S.A., Kraków, Poland., Ostrowski J; Department of Genetics, Maria Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland.; Department of Gastroenterology, Hepatology and Clinical Oncology, Medical Center for Postgraduate Education, Warsaw, Poland., Brzózka K; R&D Department, Selvita S.A., Kraków, Poland.

Publikováno v: Oncotarget [Oncotarget] 2017 May 16; Vol. 8 (20), pp. 33779-33795.

Potassium 6-Oxo-7,13,16,22-tetraazatetracyclo[12.6.2.1 8,12.0 17,21 ]tricosa-1(20),8(23),9,11,14,16,18,21-octaen-2-yne-15-carboxylate.

Autor: Blouet, Camille¹ (AUTHOR), Letast, Stéphanie¹ (AUTHOR), Robert, Thomas^2,3 (AUTHOR), Bach, Stéphane^2,3,4 (AUTHOR), Pinaud, Noël⁵ (AUTHOR), Joubert, Nicolas¹ (AUTHOR), Viaud-Massuard, Marie-Claude¹ (AUTHOR), Guillon, Jean⁶ (AUTHOR), Logé, Cédric⁷ (AUTHOR), Denevault-Sabourin, Caroline¹ (AUTHOR) caroline.denevault@univ-tours.fr

Publikováno v: Molbank. Dec2023, Vol. 2023 Issue 4, pM1735. 9p.

Choosing the Right Cell Line for Acute Myeloid Leukemia (AML) Research.

Autor: Skopek, Rafał¹ (AUTHOR) r.skopek@igbzpan.pl, Palusińska, Małgorzata¹ (AUTHOR), Kaczor-Keller, Katarzyna¹ (AUTHOR), Pingwara, Rafał² (AUTHOR), Papierniak-Wyglądała, Anna³ (AUTHOR), Schenk, Tino^4,5 (AUTHOR), Lewicki, Sławomir^6,7 (AUTHOR), Zelent, Artur¹ (AUTHOR), Szymański, Łukasz¹ (AUTHOR) r.skopek@igbzpan.pl

Publikováno v: International Journal of Molecular Sciences. Mar2023, Vol. 24 Issue 6, p5377. 34p.