Discovery of Cephalosporin-3'-Diazeniumdiolates That Show Dual Antibacterial and Antibiofilm Effects against Pseudomonas aeruginosa Clinical Cystic Fibrosis Isolates and Efficacy in a Murine Respiratory Infection Model

Autor: Rineh, A, Soren, O, McEwan, T, Ravikumar, V, Poh, WH, Azamifar, F, Naimi-Jamal, MR, Cheung, C-Y, Elliott, AG, Zuegg, J, Blaskovich, MAT, Cooper, MA, Dolange, V, Christodoulides, M, Cook, GM, Rice, SA, Faust, SN, Webb, JS, Kelso, MJ

The formation of biofilms provides a formidable defense for many bacteria against antibiotics and host immune responses. As a consequence, biofilms are thought to be the root cause of most chronic infections, including those occurring on medical indw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::ba29ba7d6bf0df2788f19125d1e58314
https://hdl.handle.net/10453/142262

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Intranasal SARS-CoV-2 Omicron variant vaccines elicit humoral and cellular mucosal immunity in female mice.

Autor: Slamanig S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, Netherlands., González-Domínguez I; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Chang LA; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lemus N; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lai TY; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Martínez JL; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Singh G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dolange V; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Abdeljawad A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kowdle S; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Noureddine M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Warang P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Singh G; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA., Lee B; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Krammer F; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Schotsaert M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Palese P; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: peter.palese@mssm.edu., Sun W; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: weina.sun@mssm.edu.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Jul; Vol. 105, pp. 105185. Date of Electronic Publication: 2024 Jun 07.