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The epithelial glycoprotein 2 (EGP-2) promoter-driven epithelial-specific expression of EGP-2 in transgenic mice: A new model to study carcinoma-directed immunotherapy

Autor: McLaughlin, PMJ, Harmsen, MC, Dokter, WHA, Kroesen, BJ, van der Molen, H, Brinker, MGL, Hollema, H, Ruiters, MHJ, Buys, CHCM, de Leij, LFMH

Publikováno v: Cancer Research, 61(10), 4105-4111. AMER ASSOC CANCER RESEARCH

The human pancarcinoma-associated epithelial glycoprotein-2 (EGP-2), a M, 38,000 transmembrane antigen also known as 17-1A or Ep-CAM, is commonly used for targeted immunotherapy of carcinomas because it is strongly expressed by most carcinomas. EGP-2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cf9b9ac1ec88bfd3683463a2a3bf93ba
https://research.rug.nl/en/publications/f069caf4-9de9-4264-bcfe-1ed610ceb75d

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Interleukin-6-induced STAT3 transactivation and Ser(727) phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4 as signal transduction components

Autor: Schuringa, JJ, Jonk, LJC, Dokter, WHA, Vellenga, E, Kruijer, W

Publikováno v: Biochemical Journal, 347, 89-96. PORTLAND PRESS LTD

In the present study, signal transducer and activator of transcription 3 (STAT3) Ser(727) phosphorylation and transactivation was investigated in relation to activation of mitogen-activated protein (MAP) kinase family members including extracellular-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::2dbf8cd8c5ee8af1839cbe4aa640672b
https://research.rug.nl/en/publications/162e44f9-8353-4ac0-9585-7aaa42130498

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Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes

Autor: Tuyt, LML, Dokter, WHA, Birbenkamp, K, Koopmans, S.B., Lummen, C, Kruijer, W, Vellenga, E

Publikováno v: Journal of Immunology, 162(8), 4893-4902. AMER ASSOC IMMUNOLOGISTS

In the present study we investigated the possible involvement of the mitogen-activated protein kinase family members extracellular-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK) in mediating IL-6 gene expression in human monocytes, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::78e70f1a423fe6b3d8faeeb187fc4dde
https://research.rug.nl/en/publications/0526e7d5-08ef-40f6-9713-7df29ce76dd2

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THE SPONTANEOUS EXPRESSION OF INTERLEUKIN-1-BETA AND INTERLEUKIN-6 IS ASSOCIATED WITH SPONTANEOUS EXPRESSION OF AP-1 AND NF-KAPPA-B TRANSCRIPTION FACTOR IN ACUTE MYELOBLASTIC-LEUKEMIA CELLS

Autor: DOKTER, WHA, TUYT, L, SIERDSEMA, SJ, ESSELINK, MT, VELLENGA, E

Publikováno v: Leukemia, 9(3), 425-432. Nature Publishing Group

The nature of the spontaneous expression of cytokines that is observed in blasts of some AML patients is unclear. We studied whether or not the spontaneous expression of IL-1 beta and IL-6 is due to an increased transcription rate of the cytokine gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::3d6c97b186370b5551011f6dec222d66
https://research.rug.nl/en/publications/b53684ac-c137-47ef-aea5-15e6a9b82aa5

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Divergent effects of IL-10 and IL-4 on the proliferation and growth factor secretion by acute myeloblastic leukemic cells

Autor: Tuyt, LML, Dokter, WHA, Esselink, MT, Vellenga, E

Publikováno v: European cytokine network, 6(4), 231-235

The effects of interleukin-10 (IL-10) and IL-4 were studied on the spontaneous and IL-1, IL-3, and Granulocyte-Colony Stimulating Factor (G-CSF) supported proliferation of acute myeloid leukemic cells, IL-10 inhibited the spontaneous proliferation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::e48c1b02ac758ccfcfc365bbbaf9675f
https://research.rug.nl/en/publications/910d2688-db30-44fd-b407-eaa2340fee77

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INTERLEUKIN-4-MEDIATED INHIBITION OF C-FOS MESSENGER-RNA EXPRESSION - ROLE OF THE LIPOXYGENASE DIRECTED PATHWAY

Autor: DOKTER, WHA, SIERDSEMA, SJ, ESSELINK, MT, HALIE, MR, VELLENGA, E

Publikováno v: Leukemia, 8(7), 1181-1184. Nature Publishing Group

Interleukin-4 inhibits several monocyte functions like A23187-induced expression of cytokines and c-fos and c-jun protooncogene mRNA expression. In an attempt to elucidate the mechanism by which this inhibitive effect is mediated, we compared the eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::4f9ffa690889705d5cd2821826446b2e
https://research.rug.nl/en/publications/5ad59043-ccd8-48ee-b8ed-b1beedc620c9

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INTERLEUKIN-4 MESSENGER-RNA AND PROTEIN IN ACTIVATED HUMAN T-CELLS ARE ENHANCED BY INTERLEUKIN-7

Autor: DOKTER, WHA, SIERDSEMA, SJ, ESSELINK, MT, HALIE, MR, VELLENGA, E

Publikováno v: Experimental Hematology, 22(1), 74-79. ELSEVIER SCIENCE INC

We studied the effect of the stroma-derived cytokine interleukin-7 (IL-7) on the expression of IL-4 in human T cells at mRNA and protein level. The results demonstrate that IL-7 did not induce IL-4 mRNA in resting T cells. However, concanavalin A (co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::29a57a8bc0c793b057930c50fc8d0559
https://research.rug.nl/en/publications/aab7e82a-0fed-4a90-a9e7-10b037272791

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INTERFERON-GAMMA ENHANCES THE LPS-INDUCED G-CSF GENE-EXPRESSION IN HUMAN ADHERENT MONOCYTES, WHICH IS REGULATED AT TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL LEVELS

Autor: DEWIT, H, DOKTER, WHA, ESSELINK, MT, HALIE, MR, VELLENGA, E

Publikováno v: Experimental Hematology, 21(6), 785-790. ELSEVIER SCIENCE INC

Human adherent monocytes were studied with regard to the expression of granulocyte colony-stimulating factor (G-CSF) at mRNA and protein levels in response to lipopolysaccharide (LPS) and gamma-interferon (IFN-gamma) stimulation. Monocytes did not ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::ab70189e0cdad797d0e927dd1379d9b1
https://research.rug.nl/en/publications/b91ce175-2e41-494f-87be-1ac6c3154f89

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